Systemic Scleroderma (Systemic Sclerosis)

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Also Known As:
Systemic Sclerosis; Scleroderma, Systemic; Sclerosis, Systemic
Networked: 4265 relevant articles (178 outcomes, 495 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Interstitial Lung Diseases (Interstitial Lung Disease)
2. Ulcer
3. Fibrosis (Cirrhosis)
4. Systemic Lupus Erythematosus (Libman-Sacks Disease)
5. Sclerosis


1. Sato, Shinichi: 80 articles (12/2015 - 06/2002)
2. Distler, Oliver: 58 articles (01/2016 - 01/2002)
3. Hasegawa, Minoru: 57 articles (09/2015 - 06/2002)
4. Allanore, Yannick: 55 articles (10/2015 - 01/2003)
5. Matucci-Cerinic, Marco: 53 articles (07/2015 - 01/2002)
6. Denton, Christopher P: 50 articles (07/2015 - 05/2003)
7. Distler, Jörg H W: 46 articles (01/2016 - 02/2004)
8. Takehara, Kazuhiko: 46 articles (09/2015 - 06/2002)
9. Mayes, Maureen D: 44 articles (12/2015 - 09/2003)
10. Fujimoto, Manabu: 44 articles (09/2015 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Systemic Scleroderma:
1. Cyclophosphamide (Cytoxan)FDA LinkGeneric
2. Idiopathic pulmonary hypertensionIBA
3. bosentan (Tracleer)FDA Link
4. Iloprost (Ventavis)FDA Link
5. Endothelin Receptors (Endothelin Receptor)IBA
6. imatinib (Gleevec)FDA Link
7. Cyclosporine (Ciclosporin)FDA LinkGeneric
8. AntibodiesIBA
9. Penicillamine (Cuprimine)FDA Link
10. Collagen Type I (Type I Collagen)IBA

Therapies and Procedures

1. Photopheresis
2. Transplants (Transplant)
3. Stem Cell Transplantation
4. Phototherapy (Light Therapy)
5. Lasers (Laser)
07/01/2008 - "The method was tested against a standard laser Doppler imaging system, which to date is considered the gold standard for non-invasive assessment of cutaneous blood flow, on both healthy subjects and patients suffering from systemic sclerosis (SSc; a pathological condition with microvessel endothelium injury). "
01/01/2014 - "The objectives of this study were to evaluate the dynamic behaviour of digital skin microvascular blood flow before and after cold stimulation using laser Doppler imaging (LDI) in children and adolescents with RP secondary to juvenile systemic sclerosis (JSS), primary RP (PRP) and healthy controls and to compare functional abnormalities measured by LDI with structural microvascular abnormalities evaluated by nailfold capillaroscopy (NFC). "
06/01/2010 - "Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study."
03/01/2010 - "The objective of this study was to investigate the dynamic behavior of the blood flow of the microvascular circulation of the fingertips before and after two cold stimuli (CS), using Laser Doppler Imaging with different intensities in patients with systemic sclerosis (SSc) and in healthy individuals. "
08/06/2002 - "To investigate the skin of patients with systemic sclerosis using confocal laser scanning microscopy in vivo and to develop histometric parameters to describe characteristic cutaneous changes of systemic sclerosis observed by this new technique, we conducted an exploratory study. "