|2.||Atopic Dermatitis (Atopic Eczema)
|3.||Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
|4.||Psoriasis (Pustulosis Palmaris et Plantaris)
|1.||Gambichler, Thilo: 9 articles (07/2013 - 02/2002)|
|2.||Kreuter, Alexander: 9 articles (07/2013 - 02/2002)|
|3.||Ihn, Hironobu: 8 articles (08/2014 - 06/2004)|
|4.||Jinnin, Masatoshi: 7 articles (08/2014 - 06/2004)|
|5.||Altmeyer, Peter: 7 articles (10/2011 - 02/2002)|
|6.||Ihn, H: 7 articles (07/2006 - 01/2000)|
|7.||Jacobe, Heidi: 6 articles (11/2014 - 12/2011)|
|8.||Zulian, Francesco: 6 articles (09/2013 - 10/2007)|
|9.||Tamaki, K: 6 articles (07/2006 - 01/2000)|
|10.||Tamaki, Kunihiko: 5 articles (08/2014 - 06/2004)|
|1.||Methotrexate (Mexate)FDA LinkGeneric
12/01/2012 - "Recent studies report that methotrexate (MTX) is beneficial in the treatment of juvenile localized scleroderma (JLS) but little is known about its long-term effectiveness. "
07/01/2011 - "This study was undertaken to assess the safety and efficacy of methotrexate (MTX) in the treatment of juvenile localized scleroderma. "
07/01/2011 - "Methotrexate treatment in juvenile localized scleroderma: a randomized, double-blind, placebo-controlled trial."
12/01/2013 - "Linear morphea: a case series with long-term follow-up of young, methotrexate-treated patients."
11/01/2013 - "Thermography for evaluation of localized scleroderma treated with methotrexate and corticosteroid."
|2.||Calcitriol (Calcijex)FDA LinkGeneric
09/01/2005 - "Our result indicates that calcitriol may be an effective agent for treating localized scleroderma in children."
01/01/1999 - "Our results indicate that calcitriol can be an effective agent for treating localized scleroderma in children."
01/01/1999 - "We assessed the efficacy of oral calcitriol treatment in seven pediatric patients with linear scleroderma. "
01/01/2003 - "Calcitriol has shown a beneficial effect in scleroderma and morphea during open studies. "
12/01/2000 - "In this study calcitriol was not more effective than placebo in patients with morphea. "
|3.||Tacrolimus (Prograf)FDA LinkGeneric
11/01/2003 - "These were the first cases of successful topical tacrolimus therapy in localized scleroderma and should be regarded as a promising treatment option for LS, especially on account of its high tolerability that permits prolonged use without side-effects."
11/01/2008 - "The aim of our study was to evaluate the efficacy of topical tacrolimus ointment in the treatment of morphea. "
01/01/2009 - "Efficacy of topical tacrolimus 0.1% in active plaque morphea: randomized, double-blind, emollient-controlled pilot study."
11/01/2008 - "It was concluded that topical tacrolimus 0.1% cream may be used in patients with morphea, particularly with early inflammatory lesions, even as a first-line treatment."
01/01/2013 - "Generalized morphea successfully treated with tacrolimus 0.1% ointment."
09/01/1994 - "The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease."
04/01/2015 - "Overproduction of collagen production by fibroblast is the cause of abnormality in morphea, and the hyperactivity mechanism of fibroblast is still unknown, although there are several mechanisms already proposed. "
06/01/2014 - "We report 2 patients with typical clinical findings of circumscribed morphea who on histopathologic examinations had histiocytes ("floating sign") surrounding individual collagen fibers in the dermis in addition to the key histologic findings of morphea. "
01/01/2014 - "Skin biopsy showing thickening of the dermal collagen bundles confirmed the clinical diagnosis of morphea. "
01/01/2013 - "A new biopsy was performed showing sclerotic superficial dermis with thickening of the collagen bundles in deep dermis and linear arrays lymphocytic infiltrate between the collagen bundles that confirm the diagnosis of morphea."
|5.||calcipotriene (calcipotriol)FDA LinkGeneric
08/01/1998 - "Topical calcipotriene 0.005% ointment may be an effective treatment for localized scleroderma, but double-blind placebo controlled studies are needed for confirmation."
08/01/1998 - "The purpose of this study was to evaluate the efficacy and safety of topical calcipotriene 0.005% ointment in the treatment of localized scleroderma. "
12/01/2003 - "Topical calcipotriol ointment in the treatment of morphea."
05/01/2001 - "Our results indicate that a combined therapy with calcipotriol ointment and low-dose UVA1 phototherapy is highly effective in childhood morphea. "
05/01/2001 - "We report an open prospective study in which the efficacy of a combined treatment with calcipotriol ointment and low-dose ultraviolet A1 (UVA1) phototherapy in childhood morphea was investigated. "
|6.||imiquimod (Aldara)FDA LinkGeneric
01/01/2011 - "This proof of concept study revealed that imiquimod 5% cream is effective in decreasing the thickening of plaque morphea and safe for pediatric use. "
03/01/2015 - "Evaluation of the efficacy and safety of topical imiquimod 5% for plaque-type morphea: a multicenter, prospective, vehicle-controlled trial."
03/01/2015 - "We aimed to evaluate the therapeutic potential and safety profile of imiquimod 5% cream in plaque-type morphea. "
01/01/2011 - "We explored the efficacy and safety of imiquimod cream in children with plaque morphea. "
01/01/2011 - "Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot study."
|7.||Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2010 - "Most PR in North America treat localized scleroderma with a combination of MTX and corticosteroids. "
05/01/1994 - "Treatment of severe forms of localized scleroderma with oral corticosteroids: follow-up study on 17 patients."
01/01/2012 - "Complete clinical examination, including careful inspection of genital mucosa, should therefore be mandatory in patients with morphea because genital LS bears a risk of evolution into squamous cell carcinoma and thus needs treatment with topical corticosteroids."
01/01/2001 - "Eosinophilic fasciitis may be separated from another sclerodermatous disorder, linear scleroderma, by its response to systemic corticosteroids. "
05/01/2003 - "Linear scleroderma "en coup de sabre" coexisting with plaque-morphea: neuroradiological manifestation and response to corticosteroids."
|8.||imatinib (Gleevec)FDA Link
10/01/2014 - "Imatinib: a novel treatment approach for generalized morphea."
10/01/2014 - "Although controlled studies are necessary to access the antifibrotic effect of imatinib in morphea, the present report shows its potential role in the treatment of this condition."
09/01/2015 - "Imatinib treatment of therapy resistant generalized deep morphea."
10/01/2014 - "We present the case of a 50-year-old Caucasian man with a generalized morphea diagnosed 10 years ago, with multiple ulcers, who was treated with imatinib over the course of 12 months. "
11/01/2010 - "Imatinib treatment of generalized localized scleroderma (morphea)."
|9.||Interleukin-6 (Interleukin 6)IBA
08/01/2000 - "These results suggest that elevated serum sIL-6R and sgp 30 may reflect activation of the IL-6 system that may be associated with the development of sclerotic lesions and autoantibody production in localized scleroderma."
09/01/2006 - "Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma."
01/01/1995 - "IL-2, IL-4 and IL-6 were detected in serum from patients with localized scleroderma but not in that from healthy controls. "
01/01/1995 - "Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma."
01/01/1995 - "In this study, serum levels of interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-6 (IL-6), which are known to be released by activated T cells, were determined using a sensitive enzyme-linked immunosorbent assay in 48 patients with localized scleroderma and 20 with systemic sclerosis, and in 20 healthy control subjects. "
|10.||gluconic acid (gluconate)FDA LinkGeneric
03/01/2010 - "The purpose of this study was to evaluate the efficacy of high-dose zinc gluconate in the treatment of morphea. "
03/01/2010 - " conclude that high-dose zinc gluconate can therefore be a valuable alternative treatment for localized scleroderma, with good tolerability, although placebo-controlled studies are necessary to confirm our results."
|1.||Phototherapy (Light Therapy)
10/01/2000 - "PUVA-cream phototherapy can be highly effective in patients with localized scleroderma even if previous therapy was unsuccessful."
01/01/1998 - "Low-dose UVA1 phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy."
08/01/2011 - "Recently, ultraviolet (UV) A1 phototherapy has been suggested as an effective treatment for localized scleroderma (LS); however, the optimal dose of UVA1 still has not been determined. "
04/01/2000 - "The conclusion is that low-dose broad-band UVA phototherapy is a very effective and safe treatment modality for localized scleroderma."
01/01/2010 - "A majority of patients can be successfully treated with topical pharmaceutical agents and phototherapy, but some of them with progressive, disseminated, and causing disability localized scleroderma are in need of systemic treatment. "
|2.||Photochemotherapy (Photodynamic Therapy)
10/01/2000 - "Recently, PUVA-bath photochemotherapy has been proven highly effective in the treatment of localized scleroderma. "
10/01/2000 - "PUVA-cream photochemotherapy induced significant clinical improvement or clearance of localized scleroderma in all patients. "
01/01/2000 - "The aim of this trial was to determine whether topical photodynamic therapy would be effective in patients with localized scleroderma. "
10/01/2000 - "We sought to assess the efficacy of PUVA-cream photochemotherapy in patients with localized scleroderma. "
10/01/2000 - "Photochemotherapy for systemic and localized scleroderma."
02/01/2011 - "At relapse after treatment, she presented with plaques, papules and nodules, histologically showing a slight interstitial lymphocytic infiltrate that resembled granuloma annulare or inflammatory morphea. "
11/01/2008 - "Within the last 20 years, approximately 31 examples of postirradiation morphea after treatment for breast cancer were reported. "
09/01/2009 - "Resolution of pansclerotic morphea after treatment with antithymocyte globulin."
05/01/2009 - "Effectiveness, side-effects and period of remission after treatment with methotrexate in localized scleroderma and related sclerotic skin diseases: an inception cohort study."
09/01/1994 - "A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). "
06/01/2013 - "The flashlamp pulsed dye laser (FLPDL) has been used in the treatment of localized morphea with promising results. "
06/01/2013 - "The purpose of this study was to evaluate the therapeutic effectiveness of the pulsed dye laser in localized scleroderma and to assess its effect on CD34+ cells, Factor XIIIa+ cells, and blood vessels. "
06/01/2013 - "Pulsed dye laser in the treatment of localized scleroderma and its effects on CD34+ and factor XIIIa+ cells: an immunohistochemical study."
07/01/2002 - "Pulsed dye laser therapy is a viable treatment option for morphea. "
07/01/2002 - "A case of plaque-type morphea was treated with 585 nm pulsed dye laser irradiation at an average fluence of 5.0 J/cm2 at bimonthly time intervals. "
|5.||Transplantation (Transplant Recipients)
01/01/2015 - "Three cases of facial linear scleroderma treated with autologous fat transplantation with acceptable results are presented. "
01/01/2015 - "Autologous fat transplantation for the treatment of linear scleroderma en coup de sabre."
12/01/2008 - "Autologous fat transplantation is an effective method for long-term correction of depressed atrophic scars left by linear scleroderma on the forehead but is less effective for corrections on the nose, infraorbital area, and chin."
01/01/2009 - "Multiple morphea-like lesions associated with chronic graft-versus-host disease after cord blood transplantation."
12/01/2008 - "Autologous fat transplantation for depressed linear scleroderma-induced facial atrophic scars."