Sclerema Neonatorum

A severe, sometimes fatal, disorder of adipose tissue occurring chiefly in preterm or debilitated infants suffering from an underlying illness and manifested by a diffuse, nonpitting induration of the affected tissue. The skin becomes cold, yellowish, mottled, and inflexible.

Networked: 31 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Panniculitis
2.	Necrosis
3.	Dermatomyositis (Dermatopolymyositis)
4.	Thrombotic Microangiopathies
5.	Zygomycosis (Phycomycosis)

Experts

1.	Estébanez, Andrea: 1 article (11/2020)
2.	Folch Briz, Rocío: 1 article (11/2020)
3.	García Vázquez, Alejandro: 1 article (11/2020)
4.	Gil Viana, Rocío: 1 article (11/2020)
5.	Guillen-Climent, Santiago: 1 article (11/2020)
6.	María Martín, José: 1 article (11/2020)
7.	Pons Benavent, Martí: 1 article (11/2020)
8.	Ramón Quiles, María Dolores: 1 article (11/2020)
9.	Sáez-Martín, Luis Carlos: 1 article (11/2020)
10.	Wick, Mark R: 1 article (05/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sclerema Neonatorum:

1.	SteroidsIBA 01/01/2017 - "Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country." 09/01/1992 - "Examples include acute neonatal fat necrosis, sclerema neonatorum, cryopanniculitis, steroid-induced panniculitis, and toxoplasmosis-related multinodular fat necrosis of Royer syndrome. " 01/01/2017 - "Here, we report a case of sclerema neonatorum in a one-week preterm baby treated successfully with parenteral steroids and antibiotics." 06/01/2015 - "Panniculitis with lipid crystallization within adipocytes may be seen in several disorders, including crystal-storing histiocytosis, gouty panniculitis, subcutaneous fat necrosis of the newborn, post-steroid panniculitis, sclerema neonatorum, oxalosis and subcutaneous fungal infections by mucormycosis, zygomycosis or aspergillosis. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/2009 - "Sclerema neonatorum was a relatively common, grave condition in this setting, heralded by poor feeding, jaundice, and bacteremia, and signaling the need for prompt antibiotic treatment." 01/01/2017 - "Here, we report a case of sclerema neonatorum in a one-week preterm baby treated successfully with parenteral steroids and antibiotics."
3.	Free RadicalsIBA 12/01/1997 - "The study indicates that the free radicals produced in sclerema neonatorum are great in amount and suggests that free radicals possibly participate in the pathogenesis of the disease."
4.	Adrenocorticotropic Hormone (ACTH)FDA Link 04/01/1956 - "[ACTH in sclerema neonatorum]." 09/30/1955 - "[ACTH and sclerema neonatorum]." 07/03/1954 - "Sclerema neonatorum treated with corticotropin (ACTH) report of two cases." 05/01/1954 - "Sclerema neonatorum; report of a case treated with ACTH." 01/24/1953 - "Sclerema neonatorum with special reference to a case successfully treated with ACTH."
5.	CortisoneFDA Link 07/01/1957 - "Sclerema neonatorum: report of three cases treated with cortisone." 10/01/1956 - "Sclerema neonatorum: recovery with cortisone." 05/01/1954 - "Sclerema neonatorum treated with cortisone." 06/01/1951 - "Cortisone in the treatment of sclerema neonatorum."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/09/1961 - "Sclerema neonatorum treated with corticosteroids." 11/15/2020 - "The clinical differential diagnosis includes sclerema neonatorum and post-corticosteroid panniculitis. " 05/01/2017 - "Predominantly-lobular panniculitides with no vasculitis include pancreatogenic panniculitis, the panniculitis of alpha-1-antitrypsin deficiency, panniculitis associated with lupus erythematosus and dermatomyositis, subcutaneous Sweet syndrome, eosinophilic panniculitis, factitial panniculitis, cold panniculitis, panniculitis following injections of corticosteroids, lipomembranous (ischemic) panniculitis; sclerema neonatorum and subcutaneous fat necrosis of the newborn, and Rosai-Dorfman disease of the subcutis. " 11/01/1955 - " the basis of encouraging reports in the literature corticosteroid therapy may be instituted with justification for a group of unrelated, intractable and discomforting diseases such as maddening pruritus ani, sclerema neonatorum, dermatomyositis, certain cases of sarcoidosis, berylliosis, Behcet's syndrome, universal calcinosis, Reiter's disease and ulcers of sickle-cell anemia. "
7.	Cystatin CIBA 01/01/2016 - "Objective To observe the effects of Ligustrazine Injection (LI) on serum cystatin C (Cys C) level in sclerema neonatorum (SN) children patients. "
8.	Palmitic Acid (Hexadecanoic Acid)IBA 03/01/1966 - "The fatty crystals in three previously published cases of sclerema neonatorum were identified by means of x-ray diffraction as sodium stearate and palmitic acid. "
9.	Intravenous Immunoglobulins (IVIG)FDA Link 08/01/2013 - "Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments."
10.	ZincIBA 10/01/1999 - "We shall also describe 2 pathologies more frequent in premature infants: sclerema neonatorum and acquired zinc deficiency."

Therapies and Procedures

1.	Therapeutics 11/01/1955 - " the basis of encouraging reports in the literature corticosteroid therapy may be instituted with justification for a group of unrelated, intractable and discomforting diseases such as maddening pruritus ani, sclerema neonatorum, dermatomyositis, certain cases of sarcoidosis, berylliosis, Behcet's syndrome, universal calcinosis, Reiter's disease and ulcers of sickle-cell anemia. "
2.	Operative Surgical Procedures 06/01/1962 - "Sclerema neonatorum complicating surgical procedures."
3.	Injections 05/01/2017 - "Predominantly-lobular panniculitides with no vasculitis include pancreatogenic panniculitis, the panniculitis of alpha-1-antitrypsin deficiency, panniculitis associated with lupus erythematosus and dermatomyositis, subcutaneous Sweet syndrome, eosinophilic panniculitis, factitial panniculitis, cold panniculitis, panniculitis following injections of corticosteroids, lipomembranous (ischemic) panniculitis; sclerema neonatorum and subcutaneous fat necrosis of the newborn, and Rosai-Dorfman disease of the subcutis. "
4.	Blood Transfusion (Blood Transfusions) 04/01/1973 - "Effect of fresh blood transfusion in the treatment of sclerema neonatorum."