|1.||Low Back Pain (Lumbago)
|4.||Back Pain (Backache)
|5.||Radiculopathy (Radiculopathy, Cervical)
|1.||Karppinen, Jaro: 12 articles (03/2010 - 01/2002)|
|2.||Koes, Bart W: 11 articles (05/2015 - 01/2006)|
|3.||Peul, Wilco C: 10 articles (05/2015 - 01/2006)|
|4.||Arts, Mark P: 8 articles (05/2015 - 01/2006)|
|5.||Brand, Ronald: 8 articles (05/2015 - 01/2006)|
|6.||Ala-Kokko, Leena: 7 articles (11/2008 - 01/2002)|
|7.||Malmivaara, Antti: 7 articles (11/2006 - 01/2002)|
|8.||Tervonen, Osmo: 6 articles (11/2006 - 01/2002)|
|9.||Seitsalo, Seppo: 6 articles (11/2006 - 01/2003)|
|10.||Hilde, G: 6 articles (01/2006 - 01/2000)|
|1.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/01/2004 - "These results suggest that inhibition of TNFalpha is beneficial in the treatment of sciatica and support a pathological role for TNFalpha in the pathogenesis of sciatica. "
04/15/2003 - "Anti-TNFalpha therapy is a promising treatment option for sciatica. "
05/01/2006 - "Two open-label studies in humans suggest dramatic efficacy of TNF-alpha antagonists in alleviating disk-related sciatica. "
09/01/2004 - "[Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?]."
01/01/2014 - "The objective of this study is to assess the value of tumor necrosis factor (TNF)-α inhibitors in the treatment of sciatica. "
|2.||Chymopapain (Chymodiactin)FDA Link
04/01/1981 - "The enzyme chymopapain, which has a wide margin of safety between its effective therapeutic and toxic doses, is effective in the management of sciatica due to a herniated intervertebral disc. "
05/01/1988 - "Safety and efficacy of chymopapain (Discase) in the treatment of sciatica due to a herniated nucleus pulposus. "
03/01/1986 - "Analgesic treatment was reduced in patients treated by chymopapain: 65% of patients in the first group report some or much improvement in their sciatica, whereas this figure was 26% in the placebo group (p less than 0.02). "
05/13/1983 - "Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. "
06/01/1986 - "Mechanism of action of intradiscal chymopapain in the treatment of sciatica: a clinical, biochemical, and radiological study."
|3.||TNFR-Fc fusion protein (etanercept)FDA Link
11/01/2013 - "Epidural etanercept may offer patients with sciatica a safe and effective nonoperative treatment."
09/01/2007 - "Dramatic etanercept-induced remission of relapsing febrile sciatic neuralgia related to p46l mutation of the tnfrsf1a gene."
09/01/2004 - "Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study."
05/01/2009 - "Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica."
02/01/2010 - "The trend appears to show no benefit to the use of etanercept over placebo in the pharmacologic treatment of sciatica."
|4.||Adrenal Cortex Hormones (Corticosteroids)IBA
10/01/1995 - "The efficacy of epidural corticosteroids in the treatment of sciatica was investigated by meta-analysis of all randomized controlled trials. "
05/01/2001 - "The efficacy of epidural corticosteroids for sciatica is controversial. "
10/01/1995 - "A meta-analysis on the efficacy of epidural corticosteroids in the treatment of sciatica."
11/01/1994 - "Despite the widespread use of epidurally administered corticosteroids in the treatment of sciatica and the failure of animal studies to demonstrate neurotoxicity from epidermally administered corticosteroids, controversy remains regarding the mechanism of action as well as the safety of this treatment. "
10/10/2013 - "[Overestimated corticosteroids in "sciatica"]."
06/15/2009 - "CEI containing local anesthetic and steroids or WFI seems to be effective when treating patients with LBP and sciatica. "
09/01/2011 - "The efficacy of pharmacological interventions in sciatica is limited and the use of systemic steroids is still controversial. "
09/01/2011 - "Randomized placebo-controlled trials evaluating the efficacy and the tolerance of systemic steroids in sciatica were included. "
09/01/2011 - "The tolerance : efficacy ratio indicates against the use of systemic steroids in sciatica."
09/01/2011 - "We aimed at evaluating the efficacy and tolerance of systemic steroids in sciatica. "
|6.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
07/15/2008 - "The evidence from the 65 trials included in this review suggests that NSAIDs are effective for short-term symptomatic relief in patients with acute and chronic low back pain without sciatica. "
01/01/2008 - "The evidence from the 65 trials included in this review suggests that NSAIDs are effective for short-term symptomatic relief in patients with acute and chronic low-back pain without sciatica. "
04/01/1997 - "The results of the 26 randomised trials that have been carried out to date, suggest that NSAIDs might be effective for short-term symptomatic relief in patients with uncomplicated low back pain, but are less effective or ineffective in patients with low back pain with sciatica and patients with sciatica with nerve root symptoms."
07/15/2008 - "Randomized trials and double-blind controlled trials of NSAIDs in nonspecific low back pain with or without sciatica were included. "
01/01/2008 - "Randomised trials and double-blind controlled trials of NSAIDs in non-specific low-back pain with or without sciatica were included. "
|7.||meloxicam (Mobic)FDA LinkGeneric
11/01/1995 - "In this randomized, double-blind, double-dummy trial, 113 patients with acute sciatica were treated with a single 15-mg dose of meloxicam given intramuscularly (n = 54) or orally (n = 59). "
04/01/2013 - "Seventy-two patients (30 men, 42 women) with LBP and/or sciatica were followed for 90 days to six years after injecting 10 mg meloxicam in 10 mL saline at each of the involved dermatomal levels. "
11/01/1995 - "Comparison of the onset and intensity of action of intramuscular meloxicam and oral meloxicam in patients with acute sciatica."
11/01/1995 - "Global efficacy evaluations by both the patients and investigators confirmed that meloxicam 15 mg in an intramuscular or oral formulation was effective in relieving pain in patients with acute sciatica. "
04/01/2013 - "Long-lasting beneficial effects of periradicular injection of meloxicam for treating chronic low back pain and sciatica."
|8.||infliximab (Remicade)FDA Link
10/01/2004 - "Efficacy of infliximab for disc herniation-induced sciatica: one-year follow-up."
11/15/2006 - "The results of experimental studies and our open-label trial support the use of infliximab in sciatica. "
12/15/2005 - "Furthermore, the results of experimental studies support the use of infliximab in sciatica. "
12/15/2005 - "Recently, we obtained encouraging results in an open-label study of infliximab in patients with disc herniation-induced sciatica. "
10/01/2004 - "The outcomes with 3 mg/kg of infliximab were compared to 62 patients who received periradicular saline for sciatica in a previous trial. "
09/01/2004 - "The control group consisted of 10 patients with severe sciatica, who took part in an observational study on i.v. methylprednisolone. "
02/15/2006 - "Patients with acute sciatica (<6-week duration) of radiologically confirmed discogenic origin were randomized to receive either a single IV bolus of 500 mg of methylprednisolone or placebo. "
06/05/1997 - "Although epidural injections of methylprednisolone may afford short-term improvement in leg pain and sensory deficits in patients with sciatica due to a herniated nucleus pulposus, this treatment offers no significant functional benefit, nor does it reduce the need for surgery."
08/01/1978 - "The results of a series of 120 epidural injections given as treatment for backache and sciatica using Methylprednisolone and local anaesthetic, performed in the Gloucestershire area, are presented and compared with other published results. "
09/01/2004 - "In this open, historical group controlled study, patients with severe sciatica had sustained improvement after a short treatment with etanercept that was better than standard care plus a short course of methylprednisolone. "
|10.||Lidocaine (Xylocaine)FDA LinkGeneric
07/01/2005 - "A total of 210 patients of Lumbar disc prolapse with sciatica were given common peroneal block by infiltrating 2% xylocaine around the common peroneal nerve 3 cm below the head of fibula on the affected side. "
01/01/2011 - "The second trial showed that BoNT injections were better than injections of corticosteroid plus lidocaine or placebo in patients with sciatica attributed to piriformis syndrome. "
11/01/1999 - "Intravenous lidocaine, amantadine, and placebo in the treatment of sciatica: a double-blind, randomized, controlled study."
01/01/2006 - "Twenty-one eligible patients who had suffered from sciatica with unilateral symptoms for 2 to 24 months received injections of betamethasone in combination with xylocaine. "
02/01/1997 - "One hundred thirty-three patients studied over 14 years, with sciatica-like pain, had their sacroiliac joints instilled with a combination of lidocaine/triamcinolone acetonide under fluoroscopy. "
02/01/2015 - "According to trials conducted in hundreds of patients with sciatica, epidural corticosteroid injections have no demonstrated efficacy beyond the placebo effect, either in the short-term or the long-term. "
12/18/2012 - "Randomized, placebo-controlled trials assessing the efficacy of epidural corticosteroid injections in participants with sciatica. "
12/18/2012 - "To determine the efficacy of epidural corticosteroid injections for sciatica compared with placebo. "
09/01/2003 - "Epidural corticosteroid injections may help to resolve additional troublesome symptoms of sciatica. "
07/01/2003 - "The efficacy of isotonic saline administered epidurally for sciatica cannot be excluded, but epidural steroid injections provide no additional improvement."
04/01/2006 - "Previous studies have demonstrated that sciatica patients have poorer postural control than healthy controls and that postural control remains unchanged 3 months after lumbar discectomy in sciatica patients. "
08/01/2003 - "The total number of primary discectomies included in the study was 531, of which 42 subsequently required a second operation for recurrent sciatica, giving a revision rate of 7.9%. "
01/01/1997 - "Thirty patients with sciatica severe enough to require a discectomy and 46 asymptomatic volunteers (controls) were included in this study. "
09/01/1993 - "Randomized trials of standard discectomy showed better short-term sciatica relief following surgery; 65% to 85% of patients reported no sciatica one year after surgery, compared with only 36% of conservatively treated patients. "
11/01/2011 - "For remaining sciatica after lumbar discectomy, we found evidence for the stability of the limitations at this stage. "
|3.||Intervertebral Disk Chemolysis (Discolysis)
04/01/1985 - "Chemonucleolysis was most effective in those patients with classical signs and symptoms of prolapsed lumbar disc disease of less than 3 months' duration and where sciatica was the predominant complaint. "
03/24/1984 - "Chemonucleolysis is an effective treatment of sciatica due to herniated lumbar disc after conservative treatments have failed. "
11/01/1981 - "Chemonucleolysis, therefore, appears to be an effective means of treatment for sciatica caused by intervertebral disc herniation. "
01/01/1994 - "We conclude that chemonucleolysis is an effective and safe method for treating sciatica by herniated lumbar discs."
06/01/2000 - "Forty patients with sciatica due to this diagnosis (confirmed by imaging) were treated either by chemonucleolysis or manipulation. "
02/01/2001 - "Forceful epidural injections produced a non-significant improvement in postdiscectomy sciatica four months after surgery. "
04/01/2011 - "The goal of this study was to assess the effects of surgery versus conservative therapy (including epidural injections) for patients with sciatica due to lumbar disc herniation. "
11/01/2003 - "Consecutive patients with sciatica who have had an electromyography study and a transforaminal epidural injection between January 1999 and July 2001. "
02/01/2014 - "In the context of acute treatment a once only lumbar caudal epidural injection represents at most a short-term effectiveness for the therapy of sciatica. "
02/01/2014 - "[Epidural injection shows no advantages over oral medication and physiotherapy in the treatment of sciatica, irrespective of the duration of symptoms]."
01/01/2005 - "There is limited evidence that: there is no significant difference in outcomes between a standard physical therapy program with continuous traction and the same program without traction, for patients with a mixed duration of LBP, with or without sciatica autotraction on its own is more effective than a physical therapy program that includes Tru-Trac traction for patients with a mixed duration of LBP with sciatica. "
01/01/2005 - "Although trials studying patients with sciatica had methodological limitations and inconsistent results, there was moderate evidence that autotraction was more effective than mechanical traction for global improvement in this population."
01/01/2007 - " The results of the available studies involving mixed groups of acute, sub-acute and chronic patients with LBP with and without sciatica were quite consistent, indicating that continuous or intermittent traction as a single treatment for LBP is not likely effective for this group. "
01/01/2007 - "Traction for patients with sciatica cannot be judged effective at present either, due to inconsistent results and methodological problems in most studies. "
01/01/2007 - "Randomized controlled trials (RCTs) involving traction to treat acute (less than four weeks duration), sub-acute (four to 12 weeks) or chronic (more than 12 weeks) non-specific LBP with or without sciatica. "