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2-acetylhydrazide 8-chloro- Dibenz(b,f)(1,4)oxazepine- 10(11H)- carboxylic acid

Inhibits the activity of prostaglandins.
Also Known As:
Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; SC-19220
Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Chakraborty, Chandan: 1 article (10/2003)
2. Timoshenko, Alexander V: 1 article (10/2003)
3. Xu, Guoxiong: 1 article (10/2003)
4. Lala, Peeyush K: 1 article (10/2003)
5. Chakrabarti, Sumontra: 1 article (10/2003)
6. Gamelli, R L: 1 article (05/2000)
7. Shoup, M: 1 article (05/2000)
8. Shankar, R: 1 article (05/2000)
9. Santangelo, S: 1 article (05/2000)

Related Diseases

1. Bone Resorption
2. Fever (Fevers)
3. Ganglion Cysts (Ganglion)
05/01/1970 - "With trains of ten or more pulses, response A is always larger than B; the ratio of A/B (1.2-21.3) is subject to animal variation.2. Both responses are abolished by tetrodotoxin and are absent from plexus-free preparations.3. Neither response is reduced by ganglion-block with (+)-tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion-paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.4. Neither response is due to a release of histamine, 5-hydroxytryptamine (5-HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin-antagonist SC-19220 (1-acetyl-2(8-chloro-10,11-dihydrodibenz [b,f] [1,4]oxazepine-10-carbonyl) hydrazine).5. The two response-components are affected differentially by a number of drugs.6. Histamine, 0.1 mug/ml., reduces response A to the level of B; this selective inhibition of the histamine-sensitive component in A is specifically antagonized by nicotine, 1-2.5 x 10(-5) g/ml.7. 5-HT, 0.1 mug/ml., and strychnine, 20-40 mug/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.8. Diphenhydramine, 10 mug/ml., produces equality of the two responses by depressing A and potentiating B.9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after alpha + beta adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea-pigs.10. "
4. Sepsis (Septicemia)
5. Hypothermia

Related Drugs and Biologics

1. Dinoprostone (PGE2)
2. hydroxide ion
3. Prostaglandins
4. Indomethacin (Indometacin)
5. Histamine (Histamine Dihydrochloride)
6. Hexamethonium (Hexamethonium Bromide)
7. Tubocurarine (Tubocurarine Chloride)
8. Tetrodotoxin (Tetradotoxin)
9. Strychnine
10. Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1. Subcutaneous Injections