Santonin

Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)

Also Known As:

Networked: 29 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Choi, Bo Gil: 3 articles (02/2011 - 01/2006)
2.	Kim, Tae Sung: 3 articles (02/2011 - 01/2006)
3.	Du, Yiqun: 2 articles (12/2020 - 05/2019)
4.	Huang, Mingzhu: 2 articles (12/2020 - 05/2019)
5.	Tao, Zhonghua: 2 articles (12/2020 - 05/2019)
6.	Wang, Chenchen: 2 articles (12/2020 - 05/2019)
7.	Wu, Zhiqiang: 2 articles (12/2020 - 05/2019)
8.	Yan, Wangjun: 2 articles (12/2020 - 05/2019)
9.	Guo, Ruihua: 2 articles (08/2019 - 01/2017)
10.	Chen, Hao: 2 articles (04/2018 - 01/2017)

Related Diseases

1.	Leukemia 05/12/2006 - "In this report, to evaluate the possibility of chemically modifying santonin into its derivatives with differentiation inducing activity, we synthesized a series of santonin derivatives, and determined their effects on cellular differentiation in the human promyelocytic leukemia HL-60 cell system. " 02/01/2011 - "Synthesis of C (6)-epimer derivatives of diacetoxy acetal derivative of santonin and their inducing effects on HL-60 leukemia cell differentiation." 01/01/2006 - "Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. " 01/01/2006 - "Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation." 05/12/2006 - "However, we reported in a previous study that santonin, a eudesmanolide sesquiterpene lactone, exerts no effects on the differentiation of leukemia cells. "
2.	Breast Neoplasms (Breast Cancer) 05/18/2019 - "Finally, santonin could also block the Raf/MEK/ERK pathway in breast cancer cells. " 05/18/2019 - "RESULTS Results showed that santonin exerts significant anti-proliferative effects on the SK-BR-3 breast cancer cells in a concentration dependent manner. " 05/18/2019 - "The main focus of this study was to evaluate the anticancer effects of a naturally occurring sesquiterpene lactone, santonin, against human breast cancer SK-BR-3 cells. " 05/18/2019 - "CONCLUSIONS The findings of this study suggest the potential for the naturally occurring sesquiterpene lactone santonin in breast cancer treatment and also suggest that it could be developed as a promising anticancer agent." 12/30/2020 - "Retracted: Naturally Occurring Sesquiterpene Lactone-Santonin, Exerts Anticancer Effects in Multi-Drug Resistant Breast Cancer Cells by Inducing Mitochondrial Mediated Apoptosis, Caspase Activation, Cell Cycle Arrest, and by Targeting Ras/Raf/MEK/ERK Signaling Pathway."
3.	Neoplasms (Cancer) 05/01/2013 - "In the present study, novel spiro derivatives of α-santonin were prepared and tested for their anticancer activity against a panel of six human cancer cell lines. "
4.	Ascariasis 11/01/1955 - "[Treatment of ascariasis with santonin]." 10/01/1954 - "[Effectiveness of the treatment of ascariasis with santonin prepared from Artemisia transiliensis]." 03/01/1982 - "These findings suggest that santonin in a 15 mg/kg dose has an efficacy similar to piperazine given at the 88 mg/kg dose level for the treatment of ascariasis in buffalo calves." 08/01/1953 - "[Comparative study of the effectiveness of hetrazan, santonin and hexylresorcinol in the treatment of ascariasis in children]." 12/01/1974 - "The cure rate resulting from a single lowest dose 2.5 mg/kg pyrantel embonate was significantly higher than those of piperazine adipate and santonin-kainic acid complex in the mass treatment for ascariasis. "
5.	Poisoning 04/01/1971 - "Hemolytic crisis in a patient treated with santonin: possible santonin poisoning." 03/01/1955 - "[A case of santonin poisoning with atypical symptomatology]." 12/01/1933 - "Santonin Poisoning." 11/01/1877 - "Poisoning by Santonin."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Antineoplastic Agents (Antineoplastics)
4.	eudesmanolide
5.	Acetals
6.	Mitogen-Activated Protein Kinase Kinases (MEKs)
7.	Caspases
8.	Kainic Acid (Kainate)
9.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
10.	NF-kappa B (NF-kB)