Salpingitis

Inflammation of the uterine salpinx, the trumpet-shaped FALLOPIAN TUBES, usually caused by ascending infections of organisms from the lower reproductive tract. Salpingitis can lead to tubal scarring, hydrosalpinx, tubal occlusion, INFERTILITY, and ectopic pregnancy (PREGNANCY, ECTOPIC)

Also Known As:

Networked: 425 relevant articles (22 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Endometritis
2.	Endometrial Neoplasms (Endometrial Cancer)
3.	Infections
4.	Infertility (Sterility)
5.	Ectopic Pregnancy

Experts

1.	Christensen, Jens Peter: 3 articles (05/2020 - 03/2016)
2.	Cohen, Craig R: 3 articles (01/2011 - 12/2004)
3.	Bisgaard, Magne: 2 articles (05/2020 - 03/2016)
4.	Christensen, Henrik: 2 articles (05/2020 - 03/2016)
5.	Thøfner, Ida: 2 articles (05/2020 - 12/2019)
6.	Seidman, Jeffrey D: 2 articles (09/2016 - 05/2015)
7.	Debattista, Joseph: 2 articles (04/2011 - 06/2003)
8.	Timms, Peter: 2 articles (04/2011 - 06/2003)
9.	Gichuhi, Joseph W: 2 articles (01/2011 - 04/2006)
10.	Mugo, Nelly R: 2 articles (01/2011 - 04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Salpingitis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/1993 - "[Medical management of chronic Chlamydia trachomatis salpingitis resistant to usual antibiotics. " 01/01/1993 - "Antibiotic association cured all the mild and moderate salpingitis with independence of bacterial etiology. " 10/01/2023 - "Groups of treatment of antibiotics and LLE were established to verify the feasibility of the lotus leaf extract in treating salpingitis. " 09/01/2002 - "Salpingitis caused by Acinetobacter species was diagnosed and antibiotic treatment was administered. " 09/01/1997 - "Use of an experimental model of chlamydial salpingitis in mice for the evaluation of activity of antibiotics and anti-inflammatory drugs on fertility."
2.	Doxycycline (Periostat)FDA LinkGeneric 01/01/1986 - "Evaluation of doxycycline in the treatment of chlamydial salpingitis." 06/01/1982 - " Patients who developed acute salpingitis were treated with doxycycline. " 10/01/1983 - " For acute salpingitis without peritonitis, therapy is with doxycycline. " 11/15/1977 - "Clinical response of patients with gonococcal endocervicitis and endometritis-salpingitis-peritonitis to doxycycline." 02/01/1993 - "It is concluded that in most patients who had acute salpingitis associated with pretreatment high titers of serum antichlamydial antibodies, posttreatment titers may remain high even if treatment with doxycycline results in complete resolution of clinical signs and symptoms of the disease."
3.	Oral ContraceptivesIBA 03/01/1994 - "Oral contraceptives do not alter the course of experimentally induced chlamydial salpingitis in monkeys." 07/01/1988 - "Chlamydial salpingitis in female guinea pigs receiving oral contraceptives." 08/01/1985 - "The relative risk of salpingitis among oral contraceptive users versus the reference group was 0.22 (P = .005), and 0.06 (P = .001) for women infected with Chlamydia trachomatis and/or Neisseria gonorrhoeae, respectively. " 12/01/1980 - "It was shown furthermore that the use of the oral contraceptives decreases the risk of salpingitis by two thirds. " 01/01/1979 - "IUD use is associated with about a three-fold increased incidence of developing acute salpingitis in comparison with use of oral contraceptives and diaphragms. "
4.	PivampicillinIBA 01/01/1980 - "The efficacy of pivampicillin, administered in a dose of 350 mg three times daily or 500 mg twice daily, was compared in 107 patients with acute salpingitis. " 01/01/1980 - "Treatment of salpingitis with pivampicillin. " 03/30/1977 - "[Clinical evaluation of pivampicillin and doxycycline treatment in salpingitis]." 01/01/1980 - "The efficacy of 500 mg pivampicillin twice daily, 350 mg pivampicillin 3-times daily and 100 mg doxycycline daily was compared in 106 patients with salpingitis, parametritis or endometritis. "
5.	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 08/01/1979 - "In this investigation, the efficacy and safety of cefoxitin was evaluated in 109 patients--68 with salpingitis, 25 with endomyometritis, 9 with pelvic cellulitis, and 7 with pelvic abscesses. " 01/01/1990 - "A total of 54 women with acute salpingitis were treated intravenously with ampicillin/sulbactam or cefoxitin in a prospective, randomized, ongoing study. " 09/01/1990 - "Patients with uncomplicated pelvic inflammatory disease (PID) (acute salpingitis and no pelvic masses) were randomly assigned for treatment with either cefotaxime or cefoxitin. " 10/01/1983 - " For acute salpingitis with peritonitis, in order to preserve fallopian structure and function, there has to be adequate coverage for principal venereal pathogens, and treatment is a combination of cefoxitin and doxycycline. " 02/01/1983 - "There were 23 patients in the piperacillin group (acute salpingitis, 12; endomyometritis, 7; pelvic cellulitis, 2; tuboovarian abscess, 2) and 25 patients in the cefoxitin group (acute salpingitis, 13; endomyometritis, 10; tuboovarian abscess, 2). "
6.	AntibodiesIBA 11/15/1984 - "Serum antibodies seemed to offer some protection against salpingitis in chlamydia-positive cases, whereas local antibodies did not." 04/25/1987 - "[Diagnostic value of the study of anti-Chlamidia antibodies in salpingitis. " 09/01/1989 - "A protective effect associated with chlamydial serum antibodies had previously been observed in salpingitis cases. " 06/01/1987 - "In the subgroup of infertile women, the geometric mean titre of antibodies to chlamydiae correlated significantly with the presence of chronic salpingitis (p less than 0.005). " 06/01/1987 - "Of 35 women with acute salpingitis on laparoscopy, 86% had chlamydial antibodies at a titre of 1/16 or higher and 49% at a titre of 1/512 or higher. "
7.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)FDA Link 12/01/1989 - "78 cases of acute salpingitis were treated with the association Oflocet-Augmentin in a multicenter study. " 01/01/1988 - "These results demonstrate that Augmentin is as effective as the combined therapy in treating acute salpingitis and with the added advantage of its easy use and lower cost." 04/01/1987 - "41 cases of acute salpingitis were treated: either with the combination Augmentin + Tetracycline (A + T) including 21 severe cases treated intravenously for 4 days, then per os and 10 moderate cases treated per os from the beginning-or by Augmentin alone (A) per os for 10 other moderate cases. " 04/01/1987 - "[Treatment of acute salpingitis with a combination of augmentin and synthetic tetracycline or augmentin alone]." 11/01/1989 - "To test the efficacy and safety of amoxycillin/clavulanate (Augmentin), 102 hospital patients with laparoscopically confirmed acute salpingitis were treated with parenteral amoxycillin/clavulanate (1.2 g qid for three days) followed by oral amoxycillin/clavulanate (two tablets of 625 mg tid for a further six days). "
8.	Metronidazole (Metric)FDA LinkGeneric 01/01/1990 - "One was a severe pelvic infection following vaginal hysterectomy, which responded to the addition of metronidazole, the other was due to a chlamydial salpingitis, which was cured with a 10-day course of doxycycline. " 03/01/1992 - "110 patients suffering from laparoscopical verified salpingitis and desire for a baby, were treated with tetracycline (oxytetracycline or doxycycline; TC)/metronidazole (n = 67), augmentan (n = 22) or cipropfloxacin/metronidazole (n = 21). " 03/01/1992 - "[Treatment of acute salpingitis with tetracycline/metronidazole with or without additional balneotherapy, Augmentin or ciprofloxacin/metronidazole: a second-look laparoscopy study]." 01/01/1988 - "An open randomised comparative trial of the efficacy and safety of Augmentin as against the triple therapy of penicillin-gentamicin-metronidazole in acute salpingitis was conducted in forty women admitted to hospital. "
9.	Ampicillin (Omnipen)FDA LinkGeneric 01/20/1971 - "[Ampicillin in the treatment of gonorrheal salpingitis]." 01/01/1986 - "It is concluded that sulbactam/ampicillin is an effective treatment for nonchlamydial salpingitis." 01/01/1989 - "Treatment of acute salpingitis with sulbactam/ampicillin." 01/01/1986 - "Treatment of acute salpingitis with sulbactam/ampicillin. " 01/01/1990 - "The combination of sulbactam-ampicillin was compared to cefoxitin for the treatment of acute salpingitis in 40 women divided into two groups of 20 women each. "
10.	Ofloxacin (Ofloxacine)FDA LinkGeneric 01/01/1999 - "Patients identified with laparoscopic findings of salpingitis were treated with 400 mg of intravenous ofloxacin every 12 hours followed by 400 mg of oral ofloxacin every 12 hours for 10 to 14 days. " 01/01/1993 - "Thus, ofloxacin has the potential for being utilized to treat early salpingitis." 09/01/1992 - "Microbial etiology of urban emergency department acute salpingitis: treatment with ofloxacin." 01/01/1999 - "Evaluation of ofloxacin in the treatment of laparoscopically documented acute pelvic inflammatory disease (salpingitis)." 09/01/1992 - "We attempted to define the microbiologic characteristics of acute salpingitis in women presenting to an urban emergency department with pelvic inflammatory disease and to determine the effectiveness of ofloxacin in treating this disease. "

Therapies and Procedures

1.	Therapeutics 12/01/1980 - "The predictions with this model parallel the results of some recently reported studies of therapy for salpingitis, and the model may prove to be a useful tool for future trials and therapy." 02/01/2020 - "Histological investigation revealed granulomatous abscessing salpingitis with suspicion of genital TB, so antituberculous therapy was administered with success. " 05/01/1995 - "The responsible care of women with suspected acute salpingitis depends on establishing an accurate diagnosis, so that appropriate therapy can be instigated. " 01/01/1993 - " This article describes one individual's rationale for selecting candidates for ambulatory therapy of acute salpingitis." 01/01/1993 - "Proposed criteria for the selection of patients for ambulatory therapy of acute gonococcal salpingitis."
2.	Intradermal Injections 05/01/1995 - "Preliminary studies in susceptible C3H mice indicated that intradermal injection of peptide conferred some protection against the development of salpingitis. "
3.	Operative Surgical Procedures 02/01/1988 - "The results indicate that with the availability of the CO(2) laser laparoscope a significant number of patients can be treated for endometriosis, pelvic adhesions, salpingitis, and other disorders, preventing the need for future surgical procedures or medical therapy." 05/01/1992 - "Using a filter paper technique to obtain samples during the surgical procedure, we examined fluids from the reproductive tract organs of seven women with salpingitis and five controls, for evidence of tumor necrosis factor (TNF). " 10/01/2005 - "These preliminary results suggest that medical therapy with leuprolide acetate may be the first-line treatment modality for women with occlusive salpingitis isthmica nodosa associated with endometriosis, possibly avoiding a more invasive surgical procedure."
4.	Vaginal Hysterectomy 09/01/1984 - " The recommendations include the following: all patients with a prosthetic cardiac valve should receive antibiotic prophylaxis for endometrial biopsy, insertion of IUD, urethral catheterization, dilation and curettage, hysterectomy, normal vaginal delivery, cesarean section, and sigmoidoscopy (category 1); premenopausal patients undergoing vaginal hysterectomy , with or without vaginal repair, should receive prophylactic antibiotics (category 1); and postmenopausal patients, with or without estrogen replacement therapy, may receive prophylaxis (category 2); regarding abdominal hysterectomy, patients with valvular heart disease, low socioeconomic status, cervical conization preceding hysterectomy from 2-21 days, or underlying conditions making a prolonged or difficult operation likely may benefit from prophylaxis (category 2); for elective abortion, patients with valvular heart disease, or a history of acute salpingitis may benefit from prophylaxis (category 2); patients undergoing surgical management of infertility secondary to endometriosis, pelvic adhesions, or distorted tubal architecture may benefit from prophylaxis; and regarding cesarean section, indigent or medically compromised patients with rupture of membranes over 8 hours and labor only 12 hours should receive prophylaxis (category 1)." 01/01/1990 - "One was a severe pelvic infection following vaginal hysterectomy, which responded to the addition of metronidazole, the other was due to a chlamydial salpingitis, which was cured with a 10-day course of doxycycline. "
5.	Bed Rest (Bedrest) 10/01/1983 - " If the temperature is elevated and the clinical signs suggest salpingitis or pelvic infalmmation, the patient should be hospitalized to obtain a diagnostic and therapeutic laparoscopy, intravenous polyantibiotic treatment, and bed rest. " 07/01/1977 - "Good results in the treatment of acute salpingitis depend upon: (1) early diagnosis, (2) hospitalization and bed rest, (3) the use of antibiotic therapy that takes into account the polymicrobial etiology of acute salpingitis, (4) prevention of recurrent episodes of salpingitis through efforts at patient education and identification and treatment of sexual partners. "