|1.||Jan, Chung-Ren: 3 articles (10/2015 - 07/2005)|
|2.||Yang, Jai-Sing: 3 articles (11/2013 - 05/2012)|
|3.||Yu, Chun-Shu: 3 articles (11/2013 - 05/2012)|
|4.||Chung, Jing-Gung: 3 articles (11/2013 - 05/2012)|
|5.||Chung, Yu-Ting: 3 articles (02/2009 - 04/2004)|
|6.||Liu, Tsung-Yun: 3 articles (02/2009 - 04/2004)|
|7.||Chi, Chin-Wen: 3 articles (02/2009 - 04/2004)|
|8.||Chou, Chiang-Ting: 2 articles (10/2015 - 07/2005)|
|9.||Rietjens, Ivonne M C M: 2 articles (04/2014 - 08/2012)|
|10.||van Bladeren, Peter J: 2 articles (04/2014 - 08/2012)|
04/01/2014 - "Overall, the results suggest a lower tumor incidence when safrole would be tested within a relevant food matrix containing sulfotransferase inhibitors compared to dosing pure safrole. "
07/01/2012 - "Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways."
02/01/2011 - "In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. "
01/01/2014 - "These results demonstrated that safrole is potent anti-hepatoma agent and the underlying mechanism may be attributed to suppress tumor cell growth by inducing cell apoptosis. "
01/03/2005 - "Of the individuals with a history of habitual areca chewing (14 cigarette smokers and two non-smokers), one of the tumor tissue samples and five of the normal esophageal mucosa samples were positive for safrole-DNA adducts. "
|2.||Hepatocellular Carcinoma (Hepatoma)
01/01/2014 - "The aim of this study was to study the anti-hepatoma effect of safrole and elucidate its molecular mechanism, the human hepatoma BEL-7402 cells were incubated with various concentrations (40, 80, 160, 320 and 640 μg/ml) of safrole and the cell proliferation and apoptosis were evaluated. "
01/01/2014 - "Anti-hepatoma effect of safrole from Cinnamomum longepaniculatum leaf essential oil in vitro."
09/18/2012 - "Safrole, a naturally occurring product derived from spices and herbs, has been shown to be associated with the development of hepatocellular carcinoma in rodents. "
02/08/2000 - "Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report."
08/01/1981 - "Hepatocellular carcinomas (HPC) occurred in livers of mice exposed to safrole for 52-75 weeks. "
|3.||Mouth Neoplasms (Oral Cancer)
07/01/2005 - "The present study examined whether safrole could alter Ca2+ handling and growth in human oral cancer OC2 cells. "
02/01/2011 - "Safrole induces apoptosis in human oral cancer HSC-3 cells."
07/01/2005 - "Independent [Ca2+]i increases and cell proliferation induced by the carcinogen safrole in human oral cancer cells."
04/11/2004 - "It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. "
12/01/1999 - "Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history."
|4.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/01/2012 - "This study was performed to elucidate safrole-induced apoptosis in human tongue squamous carcinoma SCC-4 cells. "
07/01/2012 - "These findings indicate that safrole has a cytotoxic effect in human tongue squamous carcinoma SCC-4 cells by inducing apoptosis. "
02/01/2011 - "We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. "
02/01/2009 - "We have previously demonstrated that betel quid containing safrole induced DNA adducts are highly associated with the development of oral squamous cell carcinoma (OSCC) in Taiwan. "
03/01/1998 - "Conversely, safrole, tannic acid, and urethane yet hepatotoxicants did not show inflammatory reaction or necrosis under the condition of the present study, and hence their mode of action by which they induce proliferative response was not obvious. "
10/01/1996 - "Pretreatment with isosafrole, safrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), eugenol, isoeugenol, sesamol, and curcumin did not prevent CCl4 hepatotoxicity even at 200 mg/kg. However, isosafrole was only partly hepatoprotective if administered 10 min after the toxicant. "
|1.||Urethane (Ethyl Carbamate)
|2.||Tannins (Tannic Acid)
|4.||DNA (Deoxyribonucleic Acid)
|8.||1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
|9.||Pentachlorophenol (Sodium Pentachlorophenate)
|1.||Heterologous Transplantation (Xenotransplantation)