Saccharopine Dehydrogenases (Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming))

Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.

Also Known As:

Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming); Saccharopine Dehydrogenase (NAD+, L-Lysine Forming); Saccharopine Dehydrogenase (NADP+, L-Glutamate Forming); Saccharopine Dehydrogenase (NADP+, L-Lysine Forming); Lysine-2-Oxoglutarate Reductase; Lysine-Ketoglutarate Reductase; Dehydrogenase, Saccharopine; Dehydrogenases, Saccharopine; Lysine 2 Oxoglutarate Reductase; Lysine Ketoglutarate Reductase; Reductase, Lysine-2-Oxoglutarate; Reductase, Lysine-Ketoglutarate; Saccharopine Dehydrogenase

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - Saccharopine Dehydrogenases: 9
        Saccharopinuria: 10
        L-glutamate-forming) saccharopine dehydrogenase (NADP: 1
        human AASS protein
        lysine-forming) saccharopine dehydrogenase (NADP+
        mouse Aass protein

Experts

1.	Cho, Sang-Yun: 1 article (09/2009)
2.	Kim, Kook-Hyung: 1 article (09/2009)
3.	Kwon, Sun-Jung: 1 article (09/2009)
4.	Lee, Kyung-Mi: 1 article (09/2009)
5.	Son, Moonil: 1 article (09/2009)
6.	Yu, Jisuk: 1 article (09/2009)

Related Diseases

1.	Hyperlysinemias (Hyperlysinemia) 10/10/1984 - "In familial hyperlysinemia type II, only saccharopine dehydrogenase activity is deficient. " 05/01/1983 - "Ten patients with familial hyperlysinemia with lysine-ketoglutarate reductase deficiency, identified through newborn screening programs or family surveys, were selected for review. " 08/01/1969 - "Familial hyperlysinemia with lysine-ketoglutarate reductase insufficiency." 07/01/1976 - "In the present study, analysis of liver obtained at autopsy from a patient with familial hyperlysinemia confirmed the lysine-ketoglutarate reductase deficiency but, unexpectedly, also revealed an absence of saccharopine dehydrogenase (EC. " 05/01/1979 - "It is suggested that familial hyperlysinemia, type I, be applied to patients with major defects in lysine-ketoglutarate reductase and saccharopine dehydrogenase, and that familial hyperlysinemia, type II, to be used to designate patients in whom significant amounts of lysine-ketoglutarate reductase are retained. "
2.	Starvation 12/01/1999 - "Furthermore, enzymic and expression analyses suggest that lysine-oxoglutarate reductase/saccharopine dehydrogenase levels increase in livers of mice under starvation. " 01/01/1979 - "Starvation of the strain for histidine triggers a general depression of various histidine, leucine, arginine and lysine biosynthetic enzymes, including saccharopine dehydrogenase. "
3.	Infections 09/01/2009 - "A significant decrease or down regulation of 16 proteins including enolase, saccharopine dehydrogenase, flavohemoglobin, mannitol dehydrogenase and malate dehydrogenase caused by FgV-DK21 infection was also identified. "
4.	Cystinuria 08/01/1979 - "Hyperlysinemia with saccharopinuria due to combined lysine-ketoglutarate reductase and saccharopine dehydrogenase deficiencies presenting as cystinuria."

Related Drugs and Biologics

1.	Saccharopine Dehydrogenases (Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming))
2.	Lysine (L-Lysine)
3.	Proteins (Proteins, Gene)
4.	Phosphopyruvate Hydratase (Enolase)
5.	Oxidoreductases (Dehydrogenase)
6.	Mannitol Dehydrogenases
7.	Malate Dehydrogenase (Dehydrogenase, Malate)
8.	Leucine (L-Leucine)
9.	Histidine (L-Histidine)
10.	Enzymes