Saccharin

01/01/2020 - "Studies have shown that mice and rats fed saccharin develop weight gain and metabolic alterations, possibly related to changes in gut microbiota. "
01/01/2020 - "Rats were pair-housed with a rat from either their own line (same-line condition) or the other line (other-line condition); weight gain, saccharin intake, acoustic startle, and open field behavior were measured. "
01/01/2017 - "These data support the hypothesis that long-term use of saccharin may blunt post-absorptive EE at rest in Wistar rats, which is related to weight gain. "
01/01/2017 - "These data raised the hypothesis that reduced energy expenditure (EE) could be a potential mechanism explaining greater weight gain with saccharin use in rats. "
10/01/2016 - "Pre-test saccharin acceptance was positively correlated with subsequent chow consumption, percent weight gain, and g/kg fat mass. "

03/01/1995 - "Saccharin transit time was not helpful in assessment of degree of nasal obstruction. "
08/01/2022 - "Saccharin time, Sniffin' Sticks, Turkish Nasal Obstruction Symptom Evaluation and Sino-Nasal Outcome Test 22 scores were compared. "
01/01/2016 - "Nasal obstruction was graded using a visual analog scale (VAS) and MCC was measured using a saccharin clearance test. "
01/01/1997 - "Nasal obstruction was estimated by subjective scoring and mucociliary transport was determined by the saccharin method. "
12/01/1996 - "In only one patient was the saccharin clearance prolonged beyond 20 min, and only one patient developed nasal obstruction postburn. "

08/01/1994 - "An absolute amount of a LiCl US was administered to 24 young-adult and 24 old-age rats during taste-aversion conditioning to determine whether the superior performance of old-age rats, when a 1% body-weight injection of a LiCl US is administered 3 hr. after a saccharin CS, is due to age-related differences in US intensity or the efficacy of LiCl. "
01/01/2023 - "Skin temperature, body weight, transepidermal water loss (TEWL), skin hydration state, saccharin clearance time (SCT), and blinking frequency were measured during exposure; whereby we evaluated humidity sensation, thermal sensation, and thermal comfort. "
12/08/2020 - "Chow consumption and body weight gain were larger in the saccharin group than in the plain group. "
10/09/2019 - "Results: The data showed that saccharin at 5 mg/kg increased body weight of treated rats after 60 (59%) and 120 (67%) days of treatment. "
01/01/2018 - "We investigated the effects of long term supplementation with drinks containing saccharin on body weight and possible mechanisms of the effects in post-weanling rats. "

11/01/2018 - "The study confirms that ESS in patients with treatment-resistant chronic rhinosinusitis confers improvement in performance on the saccharin test of mucociliary function."
11/01/2018 - "The present study showed decreased saccharin time in patients with chronic rhinosinusitis three months after ESS. "
03/01/2018 - "Postheated saline irrigation saccharin transit time of chronic rhinosinusitis patients (8.4 ± 4.9 min) was not different to healthy subjects (9.2 ± 3.7 min), p = 0.69. "
07/01/2016 - "Sinonasal symptoms (Visual Analogue Scale), subjective olfactometry (Barcelona Smell Test-24, BAST-24), MCT (saccharin test), and QoL (short form SF-36, rhinosinusitis outcome measure/RSOM) were evaluated before, and 12 months after, surgery. "
04/01/2009 - "The saccharin test is a validated proof to verify the nasal mucociliary clearance time and the SNOT-20 is a disease-specific, health-related quality of-life questionnaire widely used for the assessment of rhinosinusitis. "

11/08/1985 - "In two-generation studies involving rats, however, there was evidence that the incidence of bladder tumors was significantly greater in saccharin-treated males of the second generation than in controls; the development of bladder tumors in rats seems to be a species- and organ-specific phenomenon for which there is currently no explanation. "
04/01/1985 - "Analysis of these studies leads to the conclusion that saccharin is not related to human bladder cancer."
07/01/1984 - "Based on the results of that and other rodent studies indicating an increased risk of bladder cancer associated with saccharin, the Commissioner of the Food and Drug Administration announced the agency's intention to propose a ban on saccharin. "
04/01/1982 - "Calculation of potential bias in the odds ratio illustrated by a study of saccharin use and bladder cancer."
07/01/1979 - "The review of various saccharin studies suggests that bladder tumors resulted following in utero exposure. "