|1.||Zhang, Bing: 4 articles (11/2008 - 03/2006)|
|2.||Tian, Hui: 3 articles (11/2008 - 06/2007)|
|3.||Feith, David J: 2 articles (07/2012 - 07/2009)|
|4.||Hölttä, Erkki: 2 articles (03/2011 - 12/2004)|
|5.||Järvinen, Kristiina: 2 articles (03/2011 - 12/2004)|
|6.||Xiang, Yibin: 2 articles (06/2009 - 05/2009)|
|7.||Hirth, Bradford: 2 articles (06/2009 - 05/2009)|
|8.||Celatka, Cassandra A: 2 articles (06/2009 - 05/2009)|
|9.||Willert, Erin K: 2 articles (06/2009 - 05/2009)|
|10.||Sybertz, Edmund: 2 articles (06/2009 - 05/2009)|
|1.||African Trypanosomiasis (Nagana)
06/01/2009 - "Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT)."
05/01/2009 - "Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis."
12/01/1992 - "The compound 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL73811), a potent inhibitor of S-adenosylmethionine decarboxylase, was effective in mice against six of eight clinical isolates of Trypanosoma brucei rhodesiense, the causative agent of East African sleeping sickness. "
04/01/2003 - "Molecular, biochemical and genetic characterization of ornithine decarboxylase, S -adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of the agents that cause African sleeping sickness, Chagas' disease, leishmaniasis and malaria. "
11/15/1977 - "The activity of S-adenosylmethionine decarboxylase initially decreased and then increased during prolonged starvation. "
03/15/1982 - "1. Starvation caused a marked decrease in the activity of ornithine decarboxylase in mammary gland, together with a lesser decrease in the activity of S-adenosylmethionine decarboxylase and a marked fall in milk production. "
01/01/1991 - "Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase activity (SAMD) were measured in tumour tissue in mice during periods of starvation (24 h) and refeeding. "
12/30/1982 - "The activities of two other key enzymes of polyamine biosynthesis, ornithine decarboxylase and adenosylmethionine decarboxylase, are clearly detectable and show increase during polyamine starvation. "
07/01/2012 - "S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion."
02/01/2010 - "S-adenosylmethionine decarboxylase (AdoMetDC) is a critical enzyme in the polyamine biosynthetic pathway and a subject of many structural and biochemical investigations for anti-cancer and anti-parasitic therapy. "
07/01/2009 - "S-adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme of polyamine (PA) biosynthesis, and both AdoMetDC and PA levels are often up-regulated in cancer cells. "
01/01/1988 - "Sequences for human S-adenosylmethionine decarboxylase, an enzyme involved in polyamine biosynthesis, which is elevated in tumors, have been localized on chromosome 6 and the X."
12/15/2004 - "Adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of polyamines, is often up-regulated in cancers. "
|4.||Lung Neoplasms (Lung Cancer)
01/01/2008 - "To study the inhibitory effects of antisense bicistronic recombinant adenovirus vector of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (Ad-ODC-AdoMetDCas) on polyamine biosynthesis,proliferation and invasion of lung cancer cells. "
06/01/2007 - "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth."
|5.||Brain Neoplasms (Brain Tumor)
02/01/1985 - "Uptake characteristics and growth-inhibitory effects of methylglyoxal bis(guanylhydrazone) (MGBG), a competitive inhibitor of S-adenosylmethionine decarboxylase, were investigated in 9L rat brain tumor cells and in V79 hamster lung cells. "
05/01/1987 - "Eflornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, and mitoguazone (MGBG), a competitive inhibitor of S-adenosylmethionine decarboxylase, were evaluated in a phase I-II study for patients with primary recurrent malignant brain tumors. "
|1.||Ornithine Decarboxylase (Decarboxylase, Ornithine)
|10.||diamine N-acetyltransferase (spermidine acetyltransferase)
|1.||Drug Therapy (Chemotherapy)