|1.||Lu, Shelly C: 26 articles (01/2015 - 01/2002)|
|2.||Mato, José M: 25 articles (01/2015 - 02/2002)|
|3.||Cavallaro, Rosaria A: 10 articles (01/2015 - 04/2003)|
|4.||Scarpa, Sigfrido: 10 articles (01/2015 - 04/2003)|
|5.||Fuso, Andrea: 10 articles (01/2015 - 04/2003)|
|6.||Wagner, Conrad: 8 articles (01/2015 - 05/2003)|
|7.||Stabler, Sally P: 8 articles (01/2013 - 06/2002)|
|8.||Bottiglieri, Teodoro: 7 articles (09/2015 - 01/2003)|
|9.||Nicolia, Vincenzina: 7 articles (01/2015 - 04/2008)|
|10.||Allen, Robert H: 7 articles (01/2013 - 06/2002)|
07/01/1990 - "In conclusion, short-term administration of oral S-adenosylmethionine is more effective than placebo in improving clinical and laboratory measures of intrahepatic cholestasis and offers a new therapeutic modality for the symptomatic management of this syndrome."
07/01/1990 - "Parenteral S-adenosylmethionine proved to be effective in reversing intrahepatic cholestasis in pregnant women. "
10/01/1993 - "[A meta-analysis of therapeutic trials with ademetionine in the treatment of intrahepatic cholestasis]."
01/01/1990 - "A review of the studies on the clinical use of S-adenosylmethionine (SAMe) for the symptomatic treatment of intrahepatic cholestasis."
04/01/2010 - "Therefore, ademetionine can be widely used for treatment of intrahepatic cholestasis in children."
|2.||Liver Diseases (Liver Disease)
07/01/1990 - "Based on these findings, a prospective multicenter, double-blind, placebo-controlled trial was planned to assess whether oral S-adenosylmethionine is effective in cholestatic patients with chronic liver disease. "
01/01/2008 - "[Clinical efficacy of ademetionine "Heptor" in the therapy of alcohol-dependent liver disease]."
01/01/2013 - "S-adenosylmethionine has been used in several clinical studies; however, the outcomes have been unclear and its efficacy in liver diseases continues to be debated. "
02/01/2011 - "Finally, we present a multiple isotopomer distribution analysis approach, based on transfer of deuterated methyl groups to S-adenosylmethionine and subsequent sequential methylations of PE, to quantify absolute flux rates through the PEMT pathway that are applicable to studies of liver dysfunction in clinical studies."
04/01/2013 - "Hepato- and endothelioprotective action of runihol and ademetionine in 66 male rats with liver disease induced by essential and second-line antituberculosis drugs in combination with alcohol were studied. "
04/01/2010 - "Intravenous administration of ademetionine is safe in children with DILD and it can effectively alleviate pruritus, promote the recovery of various biochemical parameters and fasten liver functional recovery in these children. "
07/01/1990 - "S-adenosylmethionine significantly (P less than 0.01) improved subjective symptoms such as pruritus, fatigue, and feeling of being unwell, whereas placebo was ineffective. "
12/01/2013 - "The assessments of health-economic parameters, liver biochemistry, signs and symptoms of IHC (fatigue, jaundice, and pruritus) were performed at two visits, i.e., at baseline and after six weeks of Ademetionine treatment. "
01/01/2013 - "The difference for spontaneous preterm births was not significant (RR 0.99; 95% CI 0.41 to 2.36, two trials, 109 women).Two trials (48 women) reported lower (better) pruritus scores for S-adenosylmethionine (SAMe) compared with placebo, while two other trials of 34 women reported no significant differences between groups.UDCA was more effective in improving pruritus than either SAMe (four trials; 133 women) or cholestyramine (one trial; 84 women), as was combined UDCA+SAMe when compared with placebo (one trial; 16 women) and SAMe alone (two trials; 68 women). "
01/01/2001 - "S-adenosylmethionine (SAMe) versus placebo (four trials, 82 women): only one trial showed significantly greater improvements in pruritus, bile salts and liver enzymes with SAMe. "
05/01/2002 - "Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis."
11/20/1987 - "In a long-term multicenter open trial involving 10 general practitioners, the efficacy and tolerance of S-adenosylmethionine (SAMe) were studied for 24 months in 108 patients with osteoarthritis of the knee, hip, and spine. "
11/20/1987 - "Osteoarthritis: the clinical picture, pathogenesis, and management with studies on a new therapeutic agent, S-adenosylmethionine."
11/20/1987 - "Osteoarthritis: the clinical picture, pathogenesis, and management with studies on a new therapeutic agent, S-adenosylmethionine. "
08/01/1980 - "[S-adenosylmethionine (SAMe) in osteoarthrosis; a double-blind crossover peroral study]."
|5.||Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)
01/01/2005 - "Some complementary and alternative medicinal agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis. "
06/01/1999 - "The aim of this study was to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis. "
06/01/1999 - "S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial."
08/01/2003 - "Some complementary and alternative medicine agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis. "
07/01/1998 - "S-adenosylmethionine (SAMe) increases survival in alcoholic liver cirrhosis and may have a beneficial effect in cholestatic liver disease. "
|2.||Ursodeoxycholic Acid (Urso)
|4.||Folic Acid (Vitamin M)
|6.||Ethanol (Ethyl Alcohol)
|1.||Drug Therapy (Chemotherapy)
|2.||Phototherapy (Light Therapy)
|3.||Complementary Therapies (Alternative Medicine)
|4.||Exercise Therapy (Therapy, Exercise)