Ryanodine

A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.

Also Known As:

Networked: 346 relevant articles (11 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Murayama, Takashi: 3 articles (01/2022 - 12/2005)
2.	Treves, Susan: 3 articles (01/2022 - 11/2011)
3.	Roston, Thomas M: 3 articles (01/2018 - 01/2017)
4.	Sanatani, Shubhayan: 3 articles (01/2018 - 01/2017)
5.	Donoso, Paulina: 3 articles (09/2008 - 12/2003)
6.	Sánchez, Gina: 3 articles (09/2008 - 12/2003)
7.	Ikemoto, Noriaki: 3 articles (03/2007 - 03/2002)
8.	Ogawa, Yasuo: 3 articles (03/2007 - 12/2005)
9.	Denizalti, Merve: 2 articles (03/2022 - 11/2018)
10.	Durlu-Kandilci, Nezahat Tugba: 2 articles (03/2022 - 11/2018)

Related Diseases

1.	Contracture 12/01/1991 - "This study supports previous work suggesting the ryanodine contracture test as an improvement in the in-vitro diagnosis of MH susceptibility." 03/01/1998 - "In this study, four end-points were investigated: time to initial contracture development (Ot); time to development of a 10-mN contracture (10t); time from addition of ryanodine to when baseline tension exceeds pre-drug tension (0tp); and time for contracture to reach 10 mN above pre-drug baseline tension (10tp). " 12/01/1991 - "In this study, contracture of 0.2g appeared significantly earlier in MHS patients (17.5 +/- 1.7 min; n = 5) during cumulative ryanodine exposition (0.4-0.8-1.6-10.0 mumol/l) than in MHN (38.2 +/- 5.4 min; n = 5). " 08/01/2004 - "Ryanodine induced contractures in all specimens. " 08/01/2004 - "The effects of ryanodine on contracture responses were measured. "
2.	Ischemia 03/01/1998 - "Five hours after ischemia, a significant reduction in [3H]ryanodine binding was observed only in the hippocampal CA1 sector. " 09/01/1992 - "Ischemia produced a significant reduction in the number of ryanodine binding sites, while the dissociation constant of the binding reaction was unaffected." 04/01/2001 - "The study also compared [3H] ryanodine binding before ischemia (control group), after 30 min of ischemia (either global ischemia (GI group) or cardioplegic arrest (CA group)), and after 20 min of reperfusion. " 10/01/1992 - "In this study, the effects of regional ischemia on intrinsic SR Ca2+ release channel function were determined by studying the Ca2+ transport and release, and [3H]ryanodine binding properties of whole muscle homogenates and SR-enriched membrane fractions from normal and ischemic myocardium. " 09/12/2003 - "The main results on cardiac muscle were as follows: 1) Ischemia for up to 45 min in normal rat hearts had no obvious effect on the equilibrium ryanodine binding constant (K(d)), while the maximum number of ryanodine binding sites (B(max)) was affected in a time-dependent manner. "
3.	Hypoxia (Hypoxemia) 07/01/2012 - "In PASMC perfused with normal KRBS, acute hypoxia caused a sustained increase in [Ca(2+)](i) that was abolished by ryanodine or XeC. " 09/01/2007 - "The results provide evidence that CCE activated by depletion of both InsP(3) and ryanodine SR Ca(2+) stores in canine PASMCs is dependent on functional InsP(3) receptors, whereas the activation of CCE by hypoxia appears to be independent of functional InsP(3) receptors." 04/01/2003 - "Importantly, ryanodine blunted hypoxic relaxation in control coronary arteries, suggesting that upregulated RyR might play a novel role in altered intracellular Ca(2+) handling during hypoxia." 02/01/2003 - "Ryanodine, a specific inhibitor of SR function, significantly increased force loss in ventricle preparations under anoxia. " 08/01/2001 - "We conclude that hypoxia releases intracellular Ca2+ from ryanodine-sensitive stores by a mechanism intrinsic to pulmonary vascular smooth muscle without the need for Ca2+ influx across the plasmalemma or an endothelial factor. "
4.	Cardiac Arrhythmias (Arrythmia) 01/01/2021 - "Casq1 deficiency independently causes MH/EHS-like ventricular arrhythmia by trigger-induced Casq1 oligomerization and a relief of its inhibitory effect on ryanodine receptor-2-mediated Ca2+ release, thus revealing a new inherited arrhythmia and a novel mechanism for MH/EHS arrhythmogenesis." 08/01/2009 - "Therapeutics, which are referred to as rycals, are currently being developed to treat cardiac arrhythmia via enhancement of calstabin-ryanodine affinities that causes a stabilization of the RyR. " 01/01/2019 - "Here, we report an optogenetically based, human engineered tissue model of catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited arrhythmia caused by mutation of the cardiac ryanodine channel and triggered by exercise. " 12/01/2012 - "It was suggested that defects in CASQ2 cause protein deficiency and impair Ca(2+) uptake to the sarcoplasmic reticulum and Ca(2+)-dependent inhibition of ryanodine channels, leading to diastolic Ca(2+) leak, after-depolarizations, and arrhythmia. " 04/01/2013 - "Flecainide was effective in patients with genotype-negative CPVT, suggesting that spontaneous Ca(2+) release from ryanodine channels plays a role in arrhythmia susceptibility, similar to that in patients with genotype-positive CPVT."
5.	Inflammation (Inflammations) 01/01/2016 - "Ryanodine as well as cysteinyl leukotriene-1 receptors (RyRs and CysLT1Rs) are extensively present in the central nervous system, where they participate in regulation of cognition, motivation, inflammation and neurodegeneration. " 02/01/2000 - "ACh-stimulated accumulation of IP(3) and the binding of [(3)H]ryanodine to its receptors were not altered by inflammation. " 10/01/2020 - "Ryanodine (RYA, RyR agonist, 50 μg/kg, i.p.) was administered to BALB/c female mice 1 h before HAL administration (15 mmol/kg, i.p.), which significantly elevated plasma transaminase levels and induced severe hepatic inflammation and necrosis. " 07/01/2013 - "However, there was no significant impact of inflammation on the potency or efficacy of ryanodine-induced block of the caffeine-evoked Ca(2+) transient, or the impact of sarco-endoplasmic reticulum ATPase (SERCA) inhibition on the high K(+)-evoked Ca(2+) transient. "

Related Drugs and Biologics

1.	Caffeine (No Doz)
2.	Calcium
3.	Thapsigargin
4.	Nifedipine (Adalat)
5.	Adenosine Triphosphatases (ATPase)
6.	Diltiazem (Cardizem)
7.	Calcium Channel Blockers (Blockers, Calcium Channel)
8.	diacetylmonoxime (KBDO)
9.	Flecainide (Tambocor)
10.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Induced Heart Arrest (Cardioplegia)
3.	Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
4.	Microelectrodes
5.	Aftercare (After-Treatment)