Rotavirus Infections

04/11/2019 - "In this first detailed assessment of VE of the Rotarix® vaccine in the English national programme, we show that Rotarix® was highly effective in preventing laboratory-confirmed rotavirus infection in young children. "
01/01/2014 - "Whitehouse Station, New Jersey, USA) vaccines are effective for reducing the morbidity and mortality of rotavirus infection. "
04/01/1995 - "The WI79-9 vaccine was safe and effective in prevention of homotypic human rotavirus infection in infants. "
01/01/1984 - "Two alternatives were considered feasible in improving prophylaxis for rotavirus infections: (a) the continuous feeding of calves with 1st day colostrum as part of the ration throughout the period of greatest risk (first week of life), or (b) enhancing the efficacy of the vaccine in pregnant cows to the point where antibody concentration in the milk would remain at a protective level."
01/01/2016 - "The 2000 Millennium Development Goals helped stimulate the development of life-saving childhood vaccines for pneumococcal and rotavirus infections while greatly expanding coverage of existing vaccines. "

01/01/2021 - "Rotavirus vaccines that are safe, effective, and protective against multiple strains represent the best hope for preventing the severe consequences of rotavirus infection, especially in resource-limited settings, where access to care may be limited. "
10/01/2003 - "A new potent rotavirus vaccine, when available, will provide effective protection against severe rotavirus infection. "
09/01/2002 - "The high level of protection against symptomatic rotavirus infection provides an important incentive for development of a rotavirus vaccine."
01/01/2020 - "Inclusion of the rotavirus vaccine in the Irish primary immunization schedule has resulted in a significant reduction in the burden of rotavirus infection. "
08/01/2007 - "The objective of this study was to determine the dose response, immunogenicity, and efficacy of 2 doses of an oral, attenuated monovalent G1[P8] human rotavirus vaccine in children from the same setting in Mexico, where the natural protection against rotavirus infection was studied. "

04/01/1995 - "The purpose of this study was to determine the role of intestinal specific rotavirus IgA antibody in protection against diarrhoea due to rotavirus infection. "
11/28/2013 - "Rotavirus-specific intestinal IgA appears to be one of the principle effectors of long term protection against rotavirus infection. "
05/01/2000 - "Following primary rotavirus infection, IgA knockout mice cleared virus as effectively as IgA normal control mice. "
12/01/1995 - "Clearance of rotavirus infection in naive beta 2m knockout mice correlated with the development of intestinal rotavirus-specific immunoglobulin A. "
08/20/1995 - "It was also reported that protection against rotavirus infection in adult mice correlated with serum and stool rotavirus IgA titers. "

01/01/1988 - "The mean percentage rotavirus inhibitory activity of cord sera in the infected and non-infected infants was 50.2 +/- 21.7 and 56.6 +/- 19.2 respectively (p greater than 0.05), suggesting that cord blood antibodies do not offer significant protection against neonatal rotavirus infection."
08/11/2014 - "Association of serum antibodies with protection against rotavirus infection and disease in South Indian children."
09/01/1990 - "The viral clearance was mediated by IELs that were both Thy1+ and CD8+. These data demonstrated that the clearance of chronic rotavirus infection in SCID mice can be mediated by immune CD8+ T lymphocytes and that this clearance can occur in the absence of virus-specific antibodies."
08/11/2014 - "The study supports a correlation of serum antibodies in reducing the risk of rotavirus infections, however the potential of serum antibody titer as a correlate of protection is not clear for children in lower income settings. "
03/08/2011 - "The current study was conducted to assess whether colostrum containing rotavirus-specific antibodies (Gastrogard-R®) could protect against rotavirus infection. "

11/01/1991 - "The present study focuses on the protein specificity and heterotypic nature of cell-mediated clearance of chronic murine rotavirus infection in SCID mice. "
09/01/1999 - "Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein."
11/01/1991 - "Immunization with baculovirus-expressed recombinant rotavirus proteins VP1, VP4, VP6, and VP7 induces CD8+ T lymphocytes that mediate clearance of chronic rotavirus infection in SCID mice."
12/15/2018 - "Based on the analysis of a few proteins, earlier studies reported that rotavirus infection inhibits stress granule (SG) formation and disrupts P bodies (PBs). "
04/01/2016 - "This study demonstrates that probiotic metabolites were able to interfere with the final amount of intracellular NSP4 protein and a successful Ca(2+) regulation, which suggests a new approach to the mechanism exerted by probiotics against the rotavirus infection. "

11/10/2011 - "VP8* antigen produced in tobacco transplastomic plants confers protection against bovine rotavirus infection in a suckling mouse model."
01/01/2023 - "The aim of this study was to evaluate the performance of EpiTuub® Fecal Rotavirus Antigen Rapid Test Kit for the diagnosis of rotavirus infection among diarrheic children under five years in Ethiopian healthcare settings. "
03/01/2014 - "The diagnosis of rotavirus infection was on the basis of a set of clinical, epidemiological data and the results of para-clinical and bacteriological studies and data of detection of rotavirus antigen strain. "
04/01/2003 - "Recent studies have shown that RT-PCR may detect more symptomatic cases of rotavirus infection than antigen detection methods. "
01/01/2023 - "Rotavirus antigen tests have high sensitivity for the diagnosis of rotavirus infection in children with AGE. "

05/26/1997 - "Therefore, parenteral immunization with VP6 alone elicited large anti-rotavirus IgG responses but did not elicit protection against murine rotavirus infection in this model."
01/01/2020 - "The finding that VP6-specific IgG protect mice against rotavirus infection has important implications for rotavirus vaccination. "
11/01/2009 - "Moreover, logistic regression analysis showed that resistance to rotavirus infection most closely correlated with higher prechallenge titers of IgG antibody to homotypic VP7 (G1) and VP4 (P1A[8]). "
03/01/2007 - "Infants from the HSG who did not have rotavirus infections had significantly higher IgG GMTs in cord blood and serum samples at 6 months, than those HSG infants who had symptomatic/asymptomatic rotavirus infections (P < 0.05). "
05/17/2005 - "Serum IgG mediates mucosal immunity against rotavirus infection."

09/01/2009 - "We aimed to investigate the effect of rotavirus on ion transport and the role of NSP4 in human-derived enterocytes, and to test the efficacy of human serum immunoglobulin in a model of rotavirus infection. "
06/01/2015 - "This study represents a single-center experience of using multiple daily doses of enteral immunoglobulins in four pediatric hematopoietic stem cell transplant patients with confirmed rotavirus infections. "
10/05/2011 - "Clinical trials that address the issue of oral immunoglobulin treatment of rotavirus infection are needed."
01/01/2003 - "Therefore, researchers should be encouraged to conduct well designed trials in neonates at risk for rotavirus infections using the newer preparations of anti-rotaviral immunoglobulins (colostrum, egg yolk immunoglobulins). "
01/01/2003 - "Current evidence from one randomised controlled trial does not support the routine use of oral immunoglobulin preparations for the prevention of rotavirus infection in low birth-weight infants. "

10/01/2013 - "Thiazolides, a new class of antiviral agents effective against rotavirus infection, target viral morphogenesis, inhibiting viroplasm formation."
01/01/2021 - "Both strains improved IFN-β, IFN-λ and antiviral factors expression in PIE cells after TLR3 activation, which correlated with an enhanced resistance to rotavirus infection. "
03/01/2023 - "Thus, this study aimed to develop a novel, effective and accessible Phyto-antiviral treatment made from methanolic Ammi-visnaga seed extract against rotavirus infection. "
01/01/2022 - "Collectively, the present study demonstrates the antiviral role of NMD pathway during rotavirus infection and also reveals the underlying mechanism by which rotavirus overwhelms NMD pathway to establish successful replication."
01/01/2021 - "In this study, we evaluated the induction and antiviral potential of viperin, an ISG, during rotavirus infection. "

11/01/2018 - "This meta-analysis of real-world studies showed that Rotarix is effective in helping to prevent hospitalizations and/or emergency department visits due to rotavirus infection."
07/16/2009 - "This study estimated the cost-effectiveness of infant rotavirus vaccination with Rotarix in the UK, taking into account community rotavirus infections that do not present to the healthcare system. "
10/01/2020 - "We analyse 10 years of serial population-based diarrhoea case-control study, which also included testing for rotavirus infection (n = 3430), and 29 months of all-cause diarrhoea active surveillance from a child cohort (n = 376) from rural Ecuador during a period in which Rotarix vaccination was introduced. "
06/07/2020 - "Following the introduction of Rotarix, a reduction in numbers of rotavirus infections occurred, coinciding with an increase in genotype diversity, along with the first recorded detection of an equine-like G3 strain in Ireland."
01/01/2016 - "Low immunogenicity of RV1 vaccine could be explained in part by exposure to high antibody titres in breast milk and early exposure to wild-type rotavirus infections. "

04/01/1999 - "[Trial of oral administration of Bifidobacterium breve for the prevention of rotavirus infections]."
12/01/2011 - "In a mouse model of rotavirus infection, effects of oral administration of CDCA on fecal rotavirus shedding were investigated. "
01/01/1985 - "Prevention of rotavirus infection by oral administration of cow colostrum containing antihumanrotavirus antibody."
01/01/1996 - "Oral administration of Rota colostrum seems to be an effective and safe means of preventing diarrhea caused by human rotavirus infection. "
10/01/1992 - "Oral administration of Rota colostrum seems to be an effective and safe means of preventing diarrhea caused by human rotavirus infection."

12/01/2006 - "This study gives, for the first time, an estimate of the incidence and the cost of rotavirus infection in day care centers in Lyon, France."
09/24/2010 - "No significant association was found between rotavirus infection and nutritional status, HIV status and attendance of day care or school. "
05/01/2010 - "Attendance at day care was a risk factor for asymptomatic rotavirus infection in children under age 5 years; living in a household with a baby that was still in diapers was a risk factor in older adults. "
12/06/2008 - "Repeated measures data for rotavirus infection in children within 14 day care centres (DCCs) in the Oxfordshire area, UK, are used to explore aspects of rotavirus transmission and immunity. "
08/01/2001 - "In a multivariant analysis age, family size, day care, breast-feeding and nationality were not predictive factors for enhanced risk to contract rotavirus infection. "

04/01/2016 - "To develop oral antibody therapy against rotavirus infection, we previously produced a recombinant fragment of llama heavy-chain antibody to rotavirus (ARP1) in rice seeds (MucoRice-ARP1). "
09/01/2013 - "High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections. "
10/01/2013 - "Infection: Rice yields new oral therapy for rotavirus infection."
01/01/2008 - "Analysis of the questionnaires indicated that rotavirus infections were likely to be more severe than any other virus infection, and children from whom a viral pathogen was identified were more likely to require rehydration therapy."
12/20/2022 - "These data raise the possibility of using therapeutics targeting cellular E3 ligases to control rotavirus infections."

01/01/2009 - "In the Netherlands about 3400 children are hospitalised each year for rehydration following rotavirus infection. "
05/01/1980 - " 95% of the cases were judged successful on oral rehydration alone for gastrointestinal effects of rotavirus infection. "
01/01/2003 - "4) At least one of the following outcomes were reported: All cause mortality during hospital stay, mortality due to rotavirus infection during hospital stay, rotavirus infection, duration of diarrhoea, need for rehydration, duration of viral excretion, duration of infection control measures, length of hospital stay in days, recurrent diarrhoea or chronic diarrhoea. "
07/01/2012 - "There was also no difference between the probiotic and placebo groups for any of the other secondary outcomes (ie, incidence of rotavirus infection, incidence of diarrhea, duration of diarrhea, incidence of recurrent diarrhea, incidence of chronic diarrhea, length of hospital stay in days, and frequency of need for rehydration). "
01/01/2008 - "Analysis of the questionnaires indicated that rotavirus infections were likely to be more severe than any other virus infection, and children from whom a viral pathogen was identified were more likely to require rehydration therapy."

01/01/2020 - "There was no significant difference in median length of stay for children hospitalized with rotavirus infection. "
10/01/2014 - "Underfives infected with rotavirus had prolonged hospital stay than those without rotavirus infection (P = 0.0001). "
08/01/2012 - "Antigenemia was positively correlated with shorter hospital stay in children with rotavirus infection. "
06/15/2012 - "Rotavirus infection is prevalent in Mwanza region and contributes to prolonged hospital stay. "
06/15/2012 - "The mean hospital stay among children with rotavirus infection was 3.66 days versus 2.5 days for those without rotavirus (p = 0.005). "