Root Resorption

Resorption in which cementum or dentin is lost from the root of a tooth owing to cementoclastic or osteoclastic activity in conditions such as trauma of occlusion or neoplasms. (Dorland, 27th ed)

Also Known As:

Networked: 1427 relevant articles (45 outcomes, 316 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inflammation (Inflammations)
2.	Wounds and Injuries (Trauma)
3.	Pain (Aches)
4.	Shock
5.	Fistula

Experts

1.	Darendeliler, M Ali: 26 articles (08/2022 - 10/2005)
2.	Poi, Wilson Roberto: 14 articles (12/2015 - 04/2006)
3.	Asgary, Saeed: 12 articles (01/2022 - 01/2011)
4.	Yoshida, Noriaki: 12 articles (01/2022 - 05/2008)
5.	Sonoda, Celso Koogi: 12 articles (12/2015 - 04/2006)
6.	Consolaro, Alberto: 11 articles (09/2019 - 10/2011)
7.	Panzarini, Sônia Regina: 11 articles (03/2018 - 04/2006)
8.	Kirschneck, Christian: 10 articles (10/2022 - 12/2014)
9.	Proff, Peter: 10 articles (10/2022 - 12/2014)
10.	Kitaura, Hideki: 10 articles (07/2022 - 09/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Root Resorption:

1.	Calcium HydroxideIBA 07/01/2008 - "The purpose of this article is to report a rare case of orthodontically induced external root resorption of a maxillary left central incisor with a large periapical radiolucency; it was treated successfully with a conservative approach that included the use of calcium hydroxide. " 04/01/2017 - "The purpose of this study was to evaluate the efficacy of several irrigation protocols in the removal of calcium hydroxide [Ca(OH)2 ] from simulated internal root resorption cavities in a complex root canal anatomy model. " 04/01/2015 - "To evaluate the efficacy of six irrigation techniques to remove calcium hydroxide (CH) from a simulated internal root resorption cavity. " 04/01/2015 - "Efficacy of different irrigation techniques in the removal of calcium hydroxide from a simulated internal root resorption cavity." 06/01/1995 - "This study examined, histologically, the healing of intentionally produced inflammatory root resorption of replanted teeth in beagle dogs, treated with short- or long-term placement of calcium hydroxide. "
2.	insulin receptor-related receptor (IRR)IBA 08/01/2015 - "We report a novel treatment option for teeth with internal root resorption (IRR) in which the lesion had perforated to the PDL and was located in the coronal aspect of the root. " 10/01/2021 - "To compare the diagnostic efficacy of different devices for visualizing digital images in detecting simulated internal root resorption (IRR). " 05/01/2022 - "This study aimed to evaluate the impact of enhancement filters in detecting small simulated internal root resorptions (IRR). " 01/01/2022 - "Objective: This study sought to evaluate the effect of conventional syringe irrigation (CSI), irrigation with XP-endo Finisher file (XP-F), passive ultrasonic irrigation (PUI), and photon-induced photoacoustic-streaming (PIPS) methods on dentine debris removal from teeth with simulated internal root resorption (IRR) cavities by using scoring and image analyzing methods. " 01/01/2021 - "This study investigated the flow of an endodontic irrigant in a single-rooted tooth with internal root resorption (IRR). "
3.	Ointments (Pastes)IBA 08/01/1987 - "Histologic evaluation of results with the use of a morphometric technique revealed that the paste eliminated inflammatory root resorption and had no damaging effects upon the periodontal membrane. " 01/01/2013 - "Intracanal placement of Multi-Cal compared with that of Sure-Paste and Meta-Paste resulted in a higher pH in simulated root resorption defects. " 07/01/2005 - "The sections were studied to evaluate six parameters: apical calcified tissue barrier, inflammatory reaction, bone and root resorption, paste extrusion and microorganisms. " 01/01/2004 - "After disappearance of the inflammatory resorption, root canal fillings were performed with ZOE paste. " 08/01/1991 - "These results do not support the theory relating bleaching-induced root resorption to an acidic pH of the bleaching pastes."
4.	Doxycycline (Periostat)FDA LinkGeneric 06/01/2019 - "In the histomorphometric analysis, the doxycycline group exhibited no improvement in either pulpal or periodontal healing of the replanted tooth after 5 minutes of dry storage, but showed a lower grade of surface root resorption (1.37±0.77) and inflammatory resorption in the teeth stored for 60 minutes in HBSS (1.33±0.71). " 06/01/2005 - "The aim of the present study was to investigate the effect of systemic administration of low-dose doxycycline (DC) on orthodontic root resorption. " 06/01/2019 - "In the micro-CT analysis, the doxycycline group showed the same rate of occurrence of periapical radiolucency as was observed in the control group, but a lower degree of root resorption in teeth replanted after 60 minutes of storage in HBSS (P<0.05). " 10/01/1993 - "Systemic doxycycline prevented both root resorption and bone loss." 10/01/1993 - "The effect of systemic doxycycline administration on frequency of root resorption cavities and extent of bone loss following periodontal surgery was studied in albino rats. "
5.	Celecoxib (Celebrex)FDA Link 12/01/2005 - "Administration of Celebrex during the application of orthodontic forces does not interfere with tooth movement and appears to offer some slight protection against root resorption." 05/01/2013 - "The amount of root resorption showed a slight, but nonsignificant decrease in group 3. This study suggests that celecoxib decreases OTM and osteoclast count. " 07/01/2009 - "Although low dose celecoxib-treated group significantly decreased the tooth movement, root resorption was similar to the control group. " 08/01/2008 - "The short and long-term celecoxib administration did not suppress the root resorption in case of experimental orthodontic force application." 12/01/2005 - "The rats that received the low dose of Celebrex showed no statistically significant difference in root resorption than that of the rats that received no dose. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2021 - "Different antibiotic combinations, showing good clinical and radiographic success in treating necrotic primary teeth, can be used effectively in NIET and this technique can be considered effective for teeth with advanced root resorption and when conventional endodontic treatment is contraindicated." 04/01/2009 - "Meta-analyses found no statistically significant difference between prescribing or not prescribing antibiotics for acceptable periodontal healing without progressive root resorption (common odds ratio = 0.90, SE = 0.29, 95% confidence intervals = 0.51-1.58). " 01/01/2009 - "There was no statistically significant difference between prescribing or not prescribing antibiotics for acceptable periodontal healing without progressive root resorption (common odds ratio, 0.90; standard error of the mean, 0.29; 95% confidence intervals, 0.51-1.58). " 01/01/2022 - "Management of External Inflammatory Root Resorption following Tooth Autotransplantation Using a Modified Combination of Triple Antibiotics." 01/01/2005 - "Splinting and medication (root canal treatment, systemic antibiotics, etc.) are targeted to minimize the initial inflammatory reaction and to reduce post-traumatic complications such as pulp necrosis and/ or external root resorption."
7.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/01/2005 - "To determine if COX-2 inhibitors like Celebrex are effective in protecting root resorption associated with orthodontic forces. " 08/01/2008 - "The aim of this study was to investigate whether the COX-2 inhibitor celecoxib offers some protection against orthodontically induced root resorption. "
8.	Acetazolamide (Diamox)FDA LinkGeneric 02/01/2006 - "In contrast, no root resorption was observed after 60 days in the acetazolamide group, confirming the efficacy of the substance in inhibiting root resorption." 02/01/2013 - "The acetazolamide is a known anti-resorptive agent, and its use as root canal dressing may increase the success rates in the treatment of root resorption. " 02/01/2013 - "It was concluded that the acetazolamide paste was effective to limit the root resorption, being more effective in limiting the replacement resorption compared with calcium hydroxide."
9.	Pemetrexed (MTA)FDA Link 11/01/2016 - "However, within the limitations of this in vitro study, the results suggest that nanohybrid MTA could not be recommended as a material of choice for cervical root resorption." 07/18/2023 - "External Inflammatory Root Resorption in Traumatized Immature Incisors: MTA Plug or Revitalization? " 06/01/2021 - "CH may be preferred for use in the first weeks following the initiation of root resorption to provide a high pH. MTA can be later applied to maintain the high pH for a longer period of time without the need for medicament exchange." 03/01/2017 - "More longitudinal studies are necessary to analyze the performance of MTA in treating external root resorptions." 12/01/2014 - "MTA also showed favourable results for all secondary outcomes measured, although again, differences between MTA and FC were not statistically significant (with the exception of pathological root resorption at 24 months and dentine bridge formation at six months). "
10.	CytokinesIBA 12/01/2017 - "The purpose of this split-mouth study were (1) to investigate the changes in cytokine profile in the gingival crevicular fluid (GCF) secondary to heavy orthodontic forces and (2) to compare the cytokine expression between participants showing high and low root resorption. " 03/01/2014 - "This study shows that tensile forces in the pulp cells enhance the expression of various cytokines via the S-A channel, which may lead to inflammatory root resorption during tooth movement. " 01/01/2018 - "Inflammatory cytokines produced under hypoxic conditions are associated with root resorption, but the mechanism has not been fully understood. " 07/01/2017 - "Statistical analysis of data showed a significant root resorption between the experimental group and control group (P<0.05), however, there was no significant difference in the expression level of the inflammatory cytokine, TGF-β1. " 07/01/2016 - "The Effect of An Angiogenic Cytokine on Orthodontically Induced Inflammatory Root Resorption."

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "Small case series suggests positive outcomes of vital pulp therapy for treating invasive cervical root resorption." 11/21/2023 - "This study aimed to assess the correlation between maxillary sinus proximity to root apices of maxillary molars and root resorption during molar distalization using clear aligner therapy (CAT). " 01/01/2023 - "The aim of this study was to evaluate the volumetric root resorption in maxillary incisors following clear aligner therapy (CAT) with low-intensity pulsed ultrasound (LIPUS), and compare the results to CAT alone. " 01/01/2021 - "The aim of this study was to evaluate and compare the amount of external apical root resorption (EARR) observed during the orthodontic treatment with pre-adjusted edgewise appliance (PEA) or clear aligner therapy (CAT) and with 2D or 3D radiographic methods of measuring the root resorption. " 07/01/2018 - "This study aims to evaluate the root resorption rate of endodontically treated mandibular primary molars with conventional endodontic treatment or LSTR therapy and to compare it with their healthy contralateral teeth. "
2.	Replantation 01/01/2021 - "This study aimed to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on replacement root resorption after replantation of avulsed teeth stored in a dry condition in dogs. " 01/01/2020 - "According to the medical history, clinical manifestations and imaging studies of the 2 patients, root resorption after replantation was diagnosed. " 02/01/2017 - "This study aimed to investigate the expression pattern of inflammatory molecules in extracted human teeth presenting with external root resorption (ERR) after replantation. " 08/01/1987 - "Histometric study of root resorption on human premolars following experimental replantation." 10/01/1980 - "The purpose of this study was to determine the root resorption pattern of teeth autotransplanted to a submucosal site and to determine whether root resorption after replantation could be prevented by delayed replantation of teeth after submucosal storage in order to regenerate damaged periodontal ligament. "
3.	Lasers (Laser) 06/01/2020 - "In the majority of the selected studies, laser treatment had a positive outcome on preventing root resorption and in promoting periodontal regeneration. " 03/29/2023 - "To investigate the efficacy of different obturation techniques on sealer penetration in teeth with internal root resorption using confocal laser microscopy. " 09/01/2020 - "No Clear Evidence for the Effect of Low-Level Laser Treatment on Orthodontically Induced Inflammatory Root Resorption: More Human Clinical Studies Are Needed." 01/01/2011 - "The aim of this study was to undertake a comprehensive quantitative investigation ofpulpal bloodflow (PBF) changes in human non-carious primary molar teeth with variable degrees of root resorption by Laser Doppler Flowmetry (LDF) and Pulse Oximetry (PO) methods. " 08/01/2003 - "The aim of this clinical and confocal laser scanning microscopic study was to compare the effects of two frequently used archwires on tooth movement and root resorption. "
4.	Pulpotomy 09/01/2018 - "The study aims to evaluate clinically and radiographically the rates of success and efficacy of Biodentine™ as pulpotomy medicament exclusively on primary molars with physiological root resorption. " 10/01/2007 - "The results of the meta-analysis of six prospective clinical trials suggested that the two popular pulpotomy medicaments were not significantly different in terms of clinical outcomes, radiographic findings, prevalence of apical and furcal destruction, internal root resorption or pulp canal obliteration. " 06/01/1981 - "[Studies on the rapidity of root resorption after pulpotomy in primary teeth (author's transl)]." 09/01/2022 - "To assess the relationship between initial inflammatory coronal pulp status in decayed primary molars treated by pulpotomy and internal root resorption after one-year follow-up. " 09/01/2022 - "Internal root resorption after pulpotomy is a pathological phenomenon and can lead to early root resorption and subsequent loss of the tooth. "
5.	Tooth Movement Techniques 06/01/2020 - "Our study provides valuable information for planning orthodontic tooth movement through the maxillary sinus, which may help to predict the occurrence and severity of root resorption." 01/01/2023 - "The effect of micro-osteoperforation on root resorption, pulp vitality, and biological changes of teeth subjected to orthodontic tooth movement: A systematic review study." 07/01/2022 - "In this study, we focused on bone and root resorption during orthodontic tooth movement in mice using anti-mouse RANKL antibody (anti-mRANKL ab). " 12/01/2021 - "The primary objective of this study was to quantify the orthodontic tooth movement (OTM) and orthodontically induced root resorption (OIRR) with differential force system in conjunction with minimal surgical insult. " 12/01/2021 - "The purpose of this study was to determine the effects of alveolar decortications (AD) closer and farther from the tooth on Orthodontic tooth movement (OTM) and root resorption. "