|1.||Holmbeck, Marissa A: 1 article (08/2015)|
|2.||Donner, Julia R: 1 article (08/2015)|
|3.||Rand, David M: 1 article (08/2015)|
|4.||Villa-Cuesta, Eugenia: 1 article (08/2015)|
|5.||Fish, Lisa: 1 article (05/2015)|
|6.||Nguyen, Hoang C B: 1 article (05/2015)|
|7.||Liu, Xuhang: 1 article (05/2015)|
|8.||Goodarzi, Hani: 1 article (05/2015)|
|9.||Tavazoie, Sohail F: 1 article (05/2015)|
|10.||Zhang, Steven: 1 article (05/2015)|
|1.||Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia)
12/26/2001 - "CPEO associated with a single nucleotide deletion in the mitochondrial tRNA(Tyr) gene."
10/01/2001 - "Functional characterisation of mitochondrial tRNA(Tyr) mutation (5877-->GA) associated with familial chronic progressive external ophthalmoplegia."
12/01/1997 - "This tRNA-Tyr mutation is tightly associated with CPEO."
12/01/1997 - "[A mitochondrial DNA mutation in the heteroplasmic tRNA-Tyr gene associated with chronic progressive external ophthalmoplegia--clinical and molecular biological study]."
12/26/2001 - "In the muscle biopsy of a female patient with chronic progressive external ophthalmoplegia (CPEO), myopathy, and exercise intolerance, the heteroplasmic deletion of a single nucleotide (DeltaT5885) in the mitochondrial tRNA tyrosine gene (tRNA(Tyr)) was found. "
01/01/2015 - "We found a new homozygous mutation in YARS2, located in the α-anticodon-binding (αACB) domain, involved in the interaction with the anticodon of the cognate mt-tRNA(Tyr).Our study confirms that MLASA must be considered in patients with congenital sideroblastic anemia and underlines the importance of early diagnosis and supportive therapy in order to prevent severe complications. "
01/01/1979 - "Analysis of the isoaccepting species of tRNATyr from normal skin and melanoma tumor tissues identified three isoacceptors; tRNATyr, represented the predominant species in normal gray skin, while tRNA2Tyr predominated in melanoma tumor tissue. "
03/25/1983 - "Some novel mutations found in the tRNA genes of tumor mitochondria were as follows: nucleotides deletions in the aminoacyl-acceptor stem of the tRNATyr gene or in the anticodon stem of the tRNATrp gene and insertions in the "YpsiC" loop of the tRNACys gene. "
|4.||Hepatocellular Carcinoma (Hepatoma)
10/22/2004 - "Under the control of U6 SnRNA promoter to further enhance transcription efficiency of the modified pre-tRNAtyr gene and subsequent antisense generation, the antisense RNA exhibited obvious suppression of cyclin D1 expression in H22 hepatoma cells. "
01/22/1980 - "The enzyme catalyzes an exchange of queuine (the base of queuosine, Q) as well as its precursors and guanine for guanine originally located in the first position of the anticodon of "undermodified" tRNATyr, tRNAHis, tRNAAsn, and tRNAAsp from an Escherichia coli mutant or rat ascites hepatoma cells. "
|5.||Mitochondrial Diseases (Mitochondrial Disease)
08/01/2015 - "Because mutations in mitochondrial tRNA(Tyr) are associated with exercise intolerance in humans, this mitochondrial-nuclear introgression model in Drosophila provides a means to dissect the molecular basis of these, and other, mitochondrial diseases that are a consequence of the joint genetic architecture of mitochondrial function. "
|1.||Mitochondrial DNA (mtDNA)
|3.||Transfer RNA (tRNA)
|4.||Val Transfer RNA
|5.||Ile Transfer RNA
|6.||Myopathy with lactic acidosis and sideroblastic anemia
|7.||Asp Transfer RNA
|8.||His Transfer RNA
|9.||Glu Transfer RNA
|10.||Asn Transfer RNA