tRNA Methyltransferases

Enzymes that catalyze the S-adenosyl-L-methionine-dependent methylation of ribonucleotide bases within a transfer RNA molecule. EC 2.1.1.

Also Known As:

Methylase, RNA; Methylases, RNA; Methyltransferase, tRNA; Methyltransferases, T RNA; Methyltransferases, tRNA; RNA Methyltransferases, T; RNA Methylase; RNA Methylases; RNA, Transfer, Methyltransferases; T RNA Methyltransferases; tRNA Methyltransferase

Networked: 60 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        tRNA Methyltransferases: 60
        Arabidopsis AT3G56120 protein
        Arabidopsis CTU2 protein
        Arabidopsis SCS9 protein
        Arabidopsis TRM9 protein
        C elegans MTTU-1 protein
        E coli TrmA protein
        E coli TrmD protein
        E coli TrmJ protein
        E coli TrmO protein
        E coli YfhQ protein
        E coli YggH protein
        human CDKAL1 protein
        human DALRD3 protein
        human METTL2A protein
        human METTL6 protein
        human NOP2 protein
        human NSUN6 protein
        human THUMPD3 protein
        human TRMO protein
        human TRMT1 protein
        human TRMT10B protein
        human TRMT12 protein
        human TRMT1L protein
        human TRMT2A protein
        human TRMT5 protein
        human TRMT61A protein
        human Trmt61B protein
        human TRMT9B protein
        human TRMU protein
        human tRNA m(5)C-methyltransferase
        mouse CDKAL1 protein
        mouse Ftsj1 protein
        mouse Nsun5 protein
        mouse Trm1-like protein
        mouse tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1
        mouse tRNA(cytosine-5)methyltransferase
        N(2),N(2)-dimethylguanosine-26-methyltransferase
        N(2),N(2)-dimethylguanosine-specific tRNA methyltransferase
        RNA ribose methylase
        S cerevisiae Gcd10 protein
        S cerevisiae GCD14 protein
        S cerevisiae NCL1 protein
        S cerevisiae RTT10 protein
        S cerevisiae SLM3 protein
        S cerevisiae Trm1-11
        S cerevisiae TRM10 protein
        S cerevisiae Trm11 protein
        S cerevisiae Trm112 protein
        S cerevisiae TRM13 protein
        S cerevisiae TRM2 protein
        S cerevisiae Trm5 protein
        S cerevisiae Trm7 protein
        S cerevisiae TRM9 protein
        S cerevisiae TYW4 protein
        S pombe Tgs1 protein
        tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
        tRNA (adenine(58)-N(1))-methyltransferase
        tRNA (guanine(10)-N(2))-dimethyltransferase
        tRNA (guanine-N1-)-methyltransferase
        tRNA (guanine-N7-)-methyltransferase
        tRNA Methyltransferase AlkB Homolog 8
        tRNA(uracil-5)-methyltransferase
        tRNA(uridine-5-)-methyltransferase
        Xenopus tRNA (cytosine-5)-methyltransferase

Experts

1.	Huang, Hua: 2 articles (01/2022 - 01/2022)
2.	Khan, Aamir Ali: 2 articles (01/2022 - 01/2022)
3.	Li, Huan: 2 articles (01/2022 - 01/2022)
4.	Liu, Xinhui: 2 articles (01/2022 - 01/2022)
5.	Pan, Ruining: 2 articles (01/2022 - 01/2022)
6.	Wang, Sijia: 2 articles (01/2022 - 01/2022)
7.	Zhao, Yue: 2 articles (01/2022 - 01/2022)
8.	Cnop, Miriam: 2 articles (11/2018 - 10/2013)
9.	Eizirik, Décio L: 2 articles (11/2018 - 10/2013)
10.	Igoillo-Esteve, Mariana: 2 articles (11/2018 - 10/2013)

Related Diseases

1.	Infections 08/17/2023 - "The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection." 08/01/2014 - "Here we report an outbreak of Klebsiella pneumoniae infections harboring extended spectrum β-lactamases (ESBL) and armA 16Sr RNA methylase that were detected in pediatric and neonatal intensive care units during the 2010 and 2011 surveys of 100 clinical strains of K. " 11/01/1973 - "The tRNA methyltransferase activity in mengovirus-infected L cells, HeLa cells, and Maden Derby bovine kidney cells has been examined during the course of infection. " 11/01/1973 - "Alteration in tRNA methyltransferase activity in mengovirus infection: host range specificity." 08/01/2011 - "Spread of 16S RNA methylase determinants at the same level as bla(CTX-M) genes in Enterobacteriaceae may seriously compromise the efficacy of aminoglycosides for treating Gram-negative infections."
2.	Neoplasms (Cancer) 01/01/2022 - "Furthermore, WBSCR22 and its cofactor tRNA methyltransferase activator subunit 11‑2 (TRMT112) functioned synergistically in PC, and concurrent ectopic OE of WBSCR22 and TRMT112 further promoted the tumor suppressive potential of WBSCR22 in PC. " 05/01/2015 - "Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties." 10/01/1976 - "MPAS, EPAS, and MEAS had KI's of 58.5, 61.7, and 24.5, respectively, for the normal tRNA methyltransferases and 15.3, 13.8, and 44.3, respectively, for the tumor tRNA methyltransferases." 10/01/1976 - "Inhibition assays revealed all three compounds to be inhibitors of normal and tumor tRNA methyltransferases. " 10/01/1976 - "Three new compounds have been synthesized and tested as in vitro inhibitors of normal and tumor tRNA methyltransferases. "
3.	Intellectual Disability (Idiocy) 01/01/2022 - "Case Report: Biallelic Variant in the tRNA Methyltransferase Domain of the AlkB Homolog 8 Causes Syndromic Intellectual Disability." 10/01/2018 - "tRNA Methyltransferase Defects and Intellectual Disability." 11/01/2017 - "Mutations in the tRNA methyltransferase 1 (TRMT1) gene have been identified as the cause of certain forms of autosomal-recessive intellectual disability (ID). " 01/01/2022 - "A new syndrome of diabetes, short stature, microcephaly and intellectual disability has been described in association with mutations in the tRNA methyltransferase 10 homologue A (TRMT10A) gene. " 11/01/2018 - "Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability."
4.	Hepatocellular Carcinoma (Hepatoma) 01/15/2023 - "The present study is the first to explore the role of tRNA methyltransferase 5 (TRMT5), which catalyzes the m1G37 modification of mitochondrial tRNAs in hepatocellular carcinoma (HCC) progression. " 11/01/1970 - "Soluble RNA methylase activity of transplantable mouse hepatomas." 01/01/1977 - "[Different properties of tRNA-methyltransferases from liver and Novikov hepatoma cells in reactions with tRNA from bacterial and mammalian cells]." 01/01/1977 - "The variations in the individual tRNA methyltransferase activities of the hepatoma and normal liver homogenates indicate a difference in the methlation of their tRNA's." 01/01/1977 - "With the use of methyl-deficient Escherichia coli tRNA as the methyl receptor and the analytical procedure for tRNA anlysis, the methylating ability of the tRNA methyltransferases in hepatoma and normal liver extracts was determined. "
5.	Plasmacytoma 02/01/1983 - "A study of some molecular and kinetic properties of two tRNA methyltransferases from mouse plasmocytoma." 01/01/1980 - "Presence of RNA methylases in intracisternal A particles purified from a mouse plasma cell tumor."

Related Drugs and Biologics

1.	Aminoglycosides
2.	Transfer RNA (tRNA)
3.	RNA (Ribonucleic Acid)
4.	Proteins (Proteins, Gene)
5.	Methyltransferases
6.	Enzymes
7.	Transferases
8.	Messenger RNA (mRNA)
9.	DNA (Deoxyribonucleic Acid)
10.	Retinal Dehydrogenase

Related Therapies and Procedures

1.	Transplantation