|1.||Hannan, Ross D: 5 articles (02/2015 - 02/2011)|
|2.||Drygin, Denis: 5 articles (08/2013 - 01/2010)|
|3.||Pearson, Richard B: 4 articles (02/2015 - 07/2012)|
|4.||Hannan, R D: 4 articles (01/2015 - 10/2000)|
|5.||Iben, Sebastian: 4 articles (01/2014 - 09/2008)|
|6.||Rice, William G: 4 articles (07/2012 - 01/2010)|
|7.||Scharffetter-Kochanek, Karin: 3 articles (01/2014 - 09/2008)|
|8.||Iwai, Yuma: 3 articles (01/2013 - 01/2009)|
|9.||Hatakeyama, Dai: 3 articles (01/2013 - 01/2009)|
|10.||Kuzuhara, Takashi: 3 articles (01/2013 - 01/2009)|
02/01/2015 - "We also highlight the critical points within this network that are providing new therapeutic opportunities for treating cancers through modulation of RNA polymerase I activity and potential novel imaging strategies. "
01/22/2015 - "Targeting RNA polymerase I to treat MYC-driven cancer."
10/01/2014 - "Therefore, down-regulation of RNA polymerase I transcription in cancer cells is an important anticancer therapeutic strategy. "
09/01/2013 - "In this regard, inhibition of RNA polymerase-I-mediated rRNA synthesis appears to be a promising mechanism for killing cancer cells. "
08/01/2013 - "Targeting RNA polymerase I transcription and the nucleolus for cancer therapy."
|2.||Human Influenza (Influenza)
12/09/2015 - "Influenza A RNA polymerase complex is formed from three components, PA, PB1, and PB2. "
01/01/2013 - "Influenza A RNA polymerase consists of the PA, PB1, and PB2 subunits, and the N-terminal domain of the PA subunit demonstrates endonuclease activity. "
07/15/2010 - "Our present results indicate the utility of the PA endonuclease assay in the screening of anti-influenza drugs and are therefore useful for future strategies to develop novel anti-influenza A drugs and for mapping the function of the influenza A RNA polymerase subunits."
08/28/2008 - "We describe the crystal structure of a large fragment of one subunit (PA) of influenza A RNA polymerase bound to a fragment of another subunit (PB1). "
01/01/2008 - "A breakthrough was made in 1999 by utilizing the cellular enzyme RNA polymerase I for the synthesis of influenza viral RNAs. "
|3.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/01/1990 - "Anti-RNA polymerase I antibodies in the urine of patients with systemic lupus erythematosus."
05/14/1987 - "Anti-RNA polymerase I antibodies were detected by radioimmunoassay in the sera of 8 out of 9 Sjögren's syndrome patients, 11 out of 19 individuals with scleroderma, and 19 out of 19 systemic lupus erythematosus patients. "
11/25/1984 - "Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients."
01/01/1992 - "Anti-RNA polymerase I (RPI) antibodies in the sera of MRL/Mp-lpr/lpr and MRL/Mp(-)+/+ mice, which develop an autoimmune disease similar to human systemic lupus erythematosus, were screened for reactivity with purified RPI or RPI which had been dephosphorylated. "
10/01/1990 - "Urine samples from patients with systemic lupus erythematosus (SLE) (n = 80), patients with rheumatoid arthritis (RA) (n = 21), and healthy controls (n = 36) were analyzed by radio-immunoassay (RIA) for anti-RNA polymerase I (RPI) antibodies. "
01/01/1981 - "The changes in RNA polymerase I activity were accompanied by moderate liver hypertrophy."
09/01/2001 - "Furthermore, UBF antisense RNA expression did not alter re-expression of the fetal gene program, which confirmed that the effect was specific for transcription by RNA polymerase I. These findings demonstrate that an increase in rRNA synthesis is required for hypertrophy of cardiomyocytes and also implicate UBF as a major regulatory factor in this process. "
09/01/2001 - "The rate-limiting step in ribosome accumulation is the transcription of the ribosomal 45S genes (rDNA) by RNA polymerase I. Our previous studies have demonstrated that increases in the expression of the rDNA transcription factor UBF correlated with hypertrophy of neonatal cardiomyocytes. "
08/15/2015 - "The failure to upregulate pre-47S ribosomal RNA (rRNA) expression in muscle undergoing hypertrophy of old mice indicated that rDNA transcription by RNA polymerase I was impaired. "
04/07/1995 - "Nuclear run-on assays and Western blots demonstrated that, concomitant with hypertrophy, norepinephrine (1 microM) increased the rate of ribosomal DNA transcription, without causing an increase in the amount of RNA polymerase I. However, the elevated rate of rRNA synthesis was accompanied by an increased cellular content of UBF protein as determined by Western analysis. "
|5.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
|1.||Ribosomal DNA (rDNA)
|3.||Transcription Factors (Transcription Factor)
|4.||transcription factor UBF
|5.||Staphylococcal Protein A (A, Protein)
|7.||Complementary RNA (cRNA)
|8.||RNA Replicase (RNA Dependent RNA Polymerase)