RNA Caps

Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abele, R: 1 article (01/2021)
2.	Altincekic, N: 1 article (01/2021)
3.	Bains, J K: 1 article (01/2021)
4.	Ceylan, B: 1 article (01/2021)
5.	Ferner, J: 1 article (01/2021)
6.	Fuks, C: 1 article (01/2021)
7.	Fürtig, B: 1 article (01/2021)
8.	Hargittay, B: 1 article (01/2021)
9.	Hengesbach, M: 1 article (01/2021)
10.	Hutchison, M T: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2018 - "The IFIT3 interaction with IFIT1 is important for restricting infection of viruses lacking 2'-O methylation in their RNA cap structures. " 01/01/2021 - "This review revisits long-past knowledge and recent studies on RNA capping among members of Spinareovirinae to help elucidate the perplex processes of RNA capping and functions of RNA cap structures during Spinareovirinae infection. "
2.	Virus Diseases (Viral Diseases) 09/01/2022 - "Flavivirus RNA cap-methylation plays an important role in viral infection, proliferation, and escape from innate immunity. "
3.	Rheumatic Diseases (Rheumatism) 04/01/1992 - "The spatial organization of two rheumatic disease-associated epitopes and the RNA "cap" structure of the U1 small nuclear ribonucleoprotein (snRNP2) was analyzed both in situ and in vitro by two independent interference immuno-assays. " 04/01/1992 - "Spatial localization of distinct rheumatic disease-associated epitopes and the RNA "cap" of the U1 snRNP particle."
4.	Papilloma (Papillomatosis) 08/01/1987 - "Identification of the major cottontail rabbit papillomavirus late RNA cap site and mapping and quantitation of an E2 and minor E6 coding mRNA in papillomas and carcinomas."
5.	Neoplasms (Cancer) 01/01/2020 - "One approach to block eIF4E function in cancer cells is based on the disruption of the interaction between eIF4E and the 5' mRNA cap structure using cap analog inhibitors. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Eukaryotic Initiation Factor-4E
3.	U1 Small Nuclear Ribonucleoprotein
4.	Messenger RNA (mRNA)
5.	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)
6.	Methyltransferases
7.	Epitopes