Rinderpest (Cattle Plague)

A viral disease of cloven-hoofed animals caused by MORBILLIVIRUS. It may be acute, subacute, or chronic with the major lesions characterized by inflammation and ulceration of the entire digestive tract. The disease was declared successfully eradicated worldwide in 2010.

Also Known As:

Networked: 257 relevant articles (11 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Smallpox (Variola)
2.	Poliomyelitis (Polio)
3.	Infections
4.	Pleuropneumonia
5.	Rabies (Hydrophobia)

Experts

1.	Barrett, T: 8 articles (07/2007 - 03/2000)
2.	Shaila, M S: 7 articles (06/2004 - 01/2001)
3.	Baron, M D: 5 articles (08/2017 - 03/2000)
4.	Barrett, Thomas: 4 articles (03/2012 - 02/2005)
5.	Anderson, J: 4 articles (11/2000 - 03/2000)
6.	Parida, Satya: 3 articles (05/2014 - 07/2007)
7.	Diallo, A: 3 articles (12/2012 - 01/2003)
8.	Bandyopadhyay, S K: 3 articles (11/2004 - 12/2000)
9.	Dhar, P: 3 articles (11/2004 - 12/2000)
10.	Singh, R P: 3 articles (11/2004 - 12/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rinderpest:

1.	VaccinesIBA 01/01/1996 - "Rinderpest (RP), a lethal disease of cattle, was almost eradicated from the African continent under Joint Project 15 (JP15), using an excellent modified live virus vaccine. " 07/01/1990 - "Tissue culture rinderpest vaccine was shown effective in protecting goats against the disease. " 02/06/2020 - "As a closely related disease to PPR of large ruminants, rinderpest was eradicated in 2011 and its vaccines subsequently got banned in order to keep rinderpest-free zones. " 01/01/2017 - "On that basis, 25 TADs that have occurred or do occur in southern Africa and for which vaccines are available, in addition to rinderpest (incorporated as a yardstick because it has been eradicated worldwide), were ranked. " 02/13/1993 - "The efficacy of a recombinant rinderpest vaccine, constructed by inserting the rinderpest virus haemagglutinin gene into attenuated vaccinia virus, LC16mO strain, was tested in cattle. "
2.	Synthetic Vaccines (Recombinant Vaccines)IBA 02/01/1997 - "Trial of a capripoxvirus-rinderpest recombinant vaccine in African cattle." 01/01/1995 - "Vaccinia virus recombinant vaccines for rinderpest." 06/01/1993 - "[Rinderpest eradication and recombinant vaccine]." 01/01/1993 - "This laboratory has recently developed several effective vaccinia virus recombinant vaccines for rinderpest. " 12/01/1989 - "We have developed an effective vaccinia virus recombinant vaccine for rinderpest which protects cattle against challenge by more than 1000 times the lethal dose of the virus. "
3.	PowdersIBA 11/22/2000 - "Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID(50) of virus per dose administered intranasally to cattle induced high titre circulating antibody responses and protection against challenge with a virulent strain of rinderpest virus. " 11/22/2000 - "Intranasal powder vaccine offers several advantages over conventional needle-administered aqueous rinderpest vaccine, including greater stability in the absence of a cold chain, reduced risk of 'needle transfer' of other microbial agents present in the vaccinated herd and lower cost." 11/22/2000 - "Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine."
4.	AntibodiesIBA 12/01/1999 - "A study was undertaken regarding the prevalence of bovine viral diarrhoea virus (BVDV) antibodies in bovine sera which tested negative for rinderpest and peste des petits ruminants virus antibodies. " 01/01/2009 - "A rinderpest competition ELISA, for the estimation of antibodies in serum samples, is used to demonstrate the methods. " 10/01/2007 - "From a total of 606 sera; 65 tissue samples and 75 swabs received, no rinderpest virus or specific gene products or antibodies against rinderpest were detected. " 06/01/2007 - "The test is specific for rinderpest because it does not detect antibodies to peste-des-petits-ruminants virus (PPRV). " 07/17/2006 - "Two months later, 88 of these animals were sampled and 21/88 were positive for antibodies specific for rinderpest. "
5.	AntigensIBA 08/01/1991 - "The percentage antibody-positivity level (taken as an approximation of past experience with rinderpest antigen and the corresponding prevalence ratio estimates of relative risk) for each variable are discussed within the context of the known characteristics of immunity to rinderpest in endemic areas and the husbandry practices of the cattle owners in the study area. " 12/01/2000 - "A 45% inhibition of the binding of the MAb to the antigen was used as the cut-off point for deciding the rinderpest status of the test samples. " 06/01/2000 - "These were tested in the field using a prototype of the pen-side test and 13 (12.15%) of the samples were found to be positive for the presence of rinderpest antigen. " 06/01/2000 - "A simple chromatographic strip-test based on Clearview technology, is under development as a pen-side test for the detection of rinderpest antigen in eye swabs taken from cattle in the field. " 07/01/1987 - "A solid phase aggregation of coated erythrocytes (SPACE) technique was standardized and used for the detection of rinderpest antigen in 129 samples of 9 visceral organs; from 50 clinical samples such as gum scraping, tongue scraping, faeces, urine, nasal swabs; blood from 18 rinderpest infected cattle and 2 field samples. "
6.	InterferonsIBA 01/01/1980 - "Studies on viral interference induced by rinderpest virus: interference and interferon induction by tissue culture rinderpest vaccine (TCRV) virus in vitro." 03/01/1982 - "Studies on viral interference induced by rinderpest virus: 4. Induction of circulating interferon and antibodies in buffaloes following inoculation with tissue culture rinderpest vaccine (TCRV) virus."
7.	Complement System Proteins (Complement)IBA 01/01/1959 - "The complement fixation test and its application to the diagnosis of rinderpest." 08/01/1978 - "Studies on the preparation of rinderpest antigen for use in conglutinating complement absorption test." 09/01/1993 - "Both institutes confirmed the presence of rinderpest using complement fixation, agar gel diffusion and immunoassays. " 06/01/1993 - "Several tests already exist, such as complement deoxyribonucleic acid (cDNA)-specific probes and polymerase chain reaction (PCR) for rinderpest and PPR, DNA probes and PCR for CBPP, capture enzyme-linked immunosorbent assay, the agglutination test and the immunobinding peroxidase test for CCPP, etc. With specific reference to these examples, the various problems faced by the OIE and CAMDA are reviewed."
8.	Nucleocapsid ProteinsIBA 01/05/2001 - "Identification of a cytotoxic T-cell epitope on the recombinant nucleocapsid proteins of Rinderpest and Peste des petits ruminants viruses presented as assembled nucleocapsids." 01/05/2001 - "We extended our study to the bovine system both to analyze the immunogenicity of these recombinant proteins in the natural hosts and to show that PBMC from cattle vaccinated with Rinderpest vaccine proliferate in vitro, in response to restimulation with soluble nucleocapsid proteins. "
9.	Recombinant ProteinsIBA 01/05/2001 - "We extended our study to the bovine system both to analyze the immunogenicity of these recombinant proteins in the natural hosts and to show that PBMC from cattle vaccinated with Rinderpest vaccine proliferate in vitro, in response to restimulation with soluble nucleocapsid proteins. "
10.	Immunoglobulin M (IgM)IBA 07/01/1975 - "None of the boys had detectable rinderpest specific IgM in their sera." 07/01/1975 - "A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis."

Therapies and Procedures

1.	Therapeutics 01/01/2015 - "European veterinarians, guarding their authority against medical researchers, opposed inoculation therapies in the case of Rinderpest in favor of veterinary policing despite recent breakthroughs in vaccine research. "
2.	Injections 11/01/1985 - "Rinderpest neutralising antibody concentrations in sera following injections of rinderpest antigen."