Rift Valley Fever

An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.

Also Known As:

Fever, Rift Valley

Networked: 307 relevant articles (22 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dengue (Dengue Fever)
2.	Yellow Fever
3.	Bluetongue
4.	Lumpy Skin Disease
5.	Virus Diseases (Viral Diseases)

Experts

1.	Ikegami, Tetsuro: 13 articles (01/2021 - 08/2006)
2.	Makino, Shinji: 9 articles (01/2021 - 08/2006)
3.	Morrill, John C: 8 articles (08/2020 - 07/2011)
4.	Brun, Alejandro: 7 articles (12/2020 - 01/2013)
5.	Peters, C J: 7 articles (10/2013 - 12/2001)
6.	Warimwe, George M: 6 articles (10/2021 - 12/2013)
7.	Richt, Juergen A: 6 articles (03/2021 - 01/2016)
8.	Kortekaas, Jeroen: 6 articles (01/2021 - 09/2011)
9.	Gilbert, Sarah C: 6 articles (11/2019 - 01/2013)
10.	Lokugamage, Nandadeva: 6 articles (01/2017 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rift Valley Fever:

1.	VaccinesIBA 01/01/2013 - "Thus, rMP12-PTNSs is highly efficacious, replicates efficiently in MRC-5 cells, and encodes a DIVA marker, all of which are important for vaccine development for Rift Valley fever." 04/01/2021 - "This necessitates development of novel vaccines that would provide dual protection against a Rift Valley fever and a more prevalent disease. " 03/01/2015 - "Although livestock vaccination is effective in preventing Rift Valley fever (RVF) epidemics, there are concerns about safety and effectiveness of the only commercially available RVF Smithburn vaccine. " 07/01/2012 - "Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. " 01/01/2019 - "Safety and efficacy of ChAdOx1 RVF vaccine against Rift Valley fever in pregnant sheep and goats."
2.	DNA (Deoxyribonucleic Acid)IBA 01/17/2009 - "The appearance of Rift Valley Fever associated clinical signs were significantly decreased among the DNA vaccinated mice and further adjustment of this strategy may result in full protection against Rift Valley Fever." 01/04/2021 - "In a recent study using DNA barcoding, we identified the plants fed upon by four Afro-tropical mosquito species that vector dengue, malaria, and Rift Valley fever. " 01/01/2013 - "In this work, we evaluated the immunogenicity and protective efficacy of recombinant plasmid DNA and modified vaccinia virus Ankara (rMVA) vectored vaccines against Rift Valley fever in mice. " 11/01/1992 - "A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were isolated or synthesized and subsequently evaluated in cell culture against the RNA-containing flaviviruses (Japanese encephalitis, yellow fever, and dengue viruses), bunyaviruses (Punta Toro, sandfly fever, and Rift Valley fever viruses), alphavirus (Venezuelan equine encephalomyelitis virus), lentivirus (human immunodeficiency virus-type 1) and the DNA-containing vaccinia virus. "
3.	Monatide (IMS 3015)IBA 02/01/2019 - "Efficacy of Montanide (IMS 3015) as an adjuvant for an inactivated Rift Valley fever (RVF) vaccine in sheep." 02/01/2019 - "This study was conducted to evaluate an adjuvant, Montanide (IMS 3015), in improving the quality of Rift Valley fever (RVF) vaccine relative to the traditional adjuvant, aluminum hydroxide gel. "
4.	Antiviral Agents (Antivirals)IBA 07/01/2012 - "A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Crosse viruses). " 12/01/2016 - "The antiviral activities were tested against three viruses; Rift Valley Fever (RVFV), Herpes simplex-I (HSV-1) and Coxsackie viruses. " 01/01/2007 - "Synthesized compounds were screened for cytotoxicity and for antiviral activity against influenza A (H1N1, H3N2 and H5N1), severe acute respiratory syndrome corona, dengue, yellow fever, Venezuelan equine encephalitis (VEE), Rift Valley fever, and Tacaribe viruses in cell culture. " 04/01/2014 - "Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever." 08/01/1986 - "Prophylaxis of Rift Valley fever with antiviral drugs, immune serum, an interferon inducer, and a macrophage activator."
5.	Glycoproteins (Glycoprotein)IBA 01/01/2023 - "IFNγ cellular responses against Rift Valley fever Gn and Gc glycoproteins were observed in all participants except one in the 5 × 1010 vp dose group. " 12/01/2002 - "As Rift Valley fever (RVF) virus, and probably all members of the family Bunyaviridae, matures in the Golgi apparatus, the targeting of the virus glycoproteins to the Golgi apparatus plays a pivotal role in the virus replication cycle. " 01/01/2016 - "A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep." 01/01/2020 - "Two monoclonal antibodies against glycoprotein Gn protect mice from Rift Valley Fever challenge by cooperative effects." 01/01/1991 - "A panel of 17 monoclonal antibodies (MAbs) to the G1 and G2 envelope glycoproteins of Rift Valley fever (RVF) virus were used to analyze the topography and functional properties of the viral antigenic sites. "
6.	Ribavirin (Virazole)FDA LinkGeneric 11/01/1991 - "[The efficacy of immobilized liposomal preparations of ribamidil in experimental Rift Valley fever]." 01/29/2005 - "Ribavirin can be indicated in some cases such as the Rift Valley fever, but is formally contraindicated in West Nile encephalitis. " 03/01/1988 - "Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) was markedly inhibitory in vitro to Adames and Balliet strains of Punta Toro virus (PTV), a Phlebovirus related to Rift Valley fever and sandfly fever viruses. " 10/01/1984 - "Combinations of ribavirin and selenazofurin were synergistic against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, and Pichinde viruses, with fractional inhibitory concentrations of 0.1, 0.2, 0.4, 0.4, respectively, but showed additive effects against Korean hemorrhagic fever and Rift Valley fever viruses. " 10/01/1984 - "Binary combinations of the N-nucleoside ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) and the C-nucleoside analog selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide) or tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide) were tested in vitro for activity against Venezuelan equine encephalomyelitis, Japanese encephalitis, yellow fever, Rift Valley fever, Korean hemorrhagic fever, and Pichinde viruses. "
7.	Subunit VaccinesIBA 10/30/2023 - "A Novel Quadruple Gene-Deleted BoHV-1-Vectored RVFV Subunit Vaccine Induces Humoral and Cell-Mediated Immune Response against Rift Valley Fever in Calves." 01/01/2016 - "A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep."
8.	Viral VaccinesIBA 10/03/2023 - "Safety and immunogenicity of inactivated Rift Valley Fever Smithburn viral vaccine in sheep." 03/01/2020 - "Single-cycle viral vaccines have been developed for various diseases such as Rift Valley fever and bluetongue, and the rational extension of these strategies could be helpful for developing single-cycle ASF vaccines. "
9.	Lysergic Acid Diethylamide (LSD)IBA 01/01/2020 - "This recombinant virus, LSD-RVF.mf, was selected to homogeneity, characterized and evaluated in cattle as a vaccine to show protection against both lumpy skin disease and Rift Valley fever in cattle. " 05/01/2013 - "Five different viral diseases of livestock, lumpy skin disease (LSD), sheep pox (SPP), goat pox (GTP), Rift Valley fever (RVF) and peste des petits ruminants (PPR), circulate in the same regions of Africa, imposing a major burden on economic activity and public health. "
10.	galidesivirIBA 12/21/2021 - "Galidesivir is a broad-spectrum antiviral compound with demonstrated in vitro and in vivo efficacy against several RNA viruses of public health concern, including those causing yellow fever, Ebola, Marburg, and Rift Valley fever. " 01/01/2022 - "Galidesivir (BCX4430) is an adenosine nucleoside analog broadly active in cell culture against multiple RNA virus families, and active in animal models of viral diseases associated with Ebola, Marburg, yellow fever, Zika, and Rift Valley fever. "

Therapies and Procedures

1.	Therapeutics 11/20/2012 - "Rift Valley fever and Toscana viruses are human pathogens for which no effective therapeutics exist. " 11/01/2010 - "Since no therapies currently exist to treat Rift Valley fever, it remains a public and animal health priority to develop safe, effective RVFV vaccines (whether for animals, humans, or both) that provide long-term protective immunity. " 01/01/2018 - "By characterizing immunological markers of lethal disease, this study furthers our understanding of RVF pathogenesis and will allow the testing of therapeutics and vaccines in the AGM model.IMPORTANCE Rift Valley Fever (RVF) is an important emerging viral disease for which we lack both an effective human vaccine and treatment. " 11/09/2015 - "Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them. " 01/01/2012 - "The present study demonstrated that the protective effect was the following: Venezuelan equine encephalitis (VEE)--cycloferon > amixin = ridostin, Rift Valley fever (RVF)--cycloferon > amixin > ridostin, predator pox (PP)--cycloferon > amixin = ridostin, that was obvious that cycloferon was the most active agent in the treatment of VEE, RVF and PP, thus making it possible to acknowledge its priority in prophylaxis and therapy of dangerous viral infections (DVI). "
2.	Subcutaneous Injections 06/01/1985 - "A Rift Valley fever vaccine trial: 2. Serological response to booster doses with a comparison of intradermal versus subcutaneous injection."
3.	Bioreactors (Bioreactor) 02/01/1971 - "A model system is described for the mass propagation of Rift Valley fever (RVF) virus, utilizing large-volume fermentor units for suspension culture of tissue cells and the subsequent production of virus. "
4.	Microspheres (Microsphere) 01/01/2019 - "A multiplex fluorescence microsphere immunoassay for increased understanding of Rift Valley fever immune responses in ruminants in Kenya."
5.	Induced Abortion (Induced Abortions) 01/01/2018 - "Rift Valley fever (RVF) is a zoonotic mosquito-borne bunyaviral disease associated with high abortion rates, neonatal deaths, and fetal malformations in ruminants, and mild to severe disease in humans. "