|1.||Xu, Xun: 2 articles (06/2015 - 01/2014)|
|2.||Liu, Xuanzhu: 2 articles (06/2015 - 01/2014)|
|3.||Choi, Byung-Ok: 2 articles (10/2013 - 09/2007)|
|4.||Castorina, Pierangela: 1 article (06/2015)|
|5.||Primignani, Paola: 1 article (06/2015)|
|6.||Soldà, Giulia: 1 article (06/2015)|
|7.||Duga, Stefano: 1 article (06/2015)|
|8.||Ambrosetti, Umberto: 1 article (06/2015)|
|9.||Cesarani, Antonio: 1 article (06/2015)|
|10.||Previtali, Stefano C: 1 article (06/2015)|
07/01/1979 - "On the basis of a study of the action of phosphoribosylpyrophosphate (PRPP) synthetase (EC 22.214.171.124.) in 22 hyperuricemic and 9 normal subjects, the authors report two cases of gout with anomalies of the kinetics of this enzyme. "
11/01/1986 - "The failure of either drug to suppress the increased activity of PRPP synthetase associated with gout is discussed."
11/01/1986 - "The activity of PRPP synthetase was significantly higher in the gout group and was not influenced by either drug. "
12/23/1982 - "Statistical analyses have shown a significant increase (p less than 0.01) in the enzymic activity of erythrocyte PRPP synthetase in both the hyperuricaemic and gout groups compared with the controls. "
12/01/1981 - "Altered isoelectric property of a superactive 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase in a patient with clinical gout."
05/01/1982 - "Since it appears possible to differentially affect PRPP synthetase activity from the different types of leukemic cells, this enzyme may be a potential target site in the chemotherapy of leukemia."
12/01/1996 - "Overproduction of ruate is caused by PRPP synthetase superactivity, HPRT deficiency, leukemia and alcohol ingestion. "
11/01/1989 - "[Purine metabolism: determination of PRPP-amidotransferase and PRPP-synthetase in lymphocytes from patients with chronic lymphatic leukemia (CLL)]."
01/01/1989 - "The nucleosides have shown promise as therapeutic agents in a mouse leukemia evaluation system but may also have future use in unravelling the complex regulation of PRPP synthetase and the dependent nucleotide synthesis pathways."
|3.||Hearing Loss (Hearing Impairment)
12/01/2012 - "Mutations in phosphoribosyl pyrophosphate synthetase 1 (PRPS1) are associated with a spectrum of non-syndromic to syndromic hearing loss. "
06/01/2015 - "Defects in this gene, encoding the phosphoribosyl pyrophosphate synthetase 1 (PRS-I) enzyme, determine either X-linked syndromic conditions associated with hearing impairment (eg, Arts syndrome and Charcot-Marie-Tooth neuropathy type X-5) or non-syndromic HL (DFNX1). "
09/01/2007 - "Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)."
|4.||Hepatocellular Carcinoma (Hepatoma)
11/01/1984 - "PRPP synthetase activity was proportionate with amounts of protein added over a range of 0.4 to 3.0 mg in both liver and hepatoma extracts. "
06/01/1974 - "Increased PRPP synthetase activity in rapidly growing hepatomas."
11/01/1984 - "Increased 5-phospho-alpha-D-ribose-1-diphosphate synthetase (ribosephosphate pyrophosphokinase, EC 126.96.36.199) activity in rat hepatomas."
11/01/1984 - "The affinity of PRPP synthetase for its substrates, ribose 5-phosphate and adenosine triphosphate (ATP), and to Mg2+ was similar in liver and hepatoma extracts. "
11/01/1984 - "The behavior of the activity of 5-phosphoribosyl 1-pyrophosphate (PRPP) synthetase (ribosephosphate pyrophosphokinase, EC 188.8.131.52) was elucidated in normal rat liver, in 11 hepatomas of different growth rates, and in rapidly growing differentiating and regenerating liver. "
06/01/2010 - "On the other hand, PRPS1 mutations cause PRPP synthetase superactivity associated with hyperuricemia and gout, sometimes including neurodevelopmental abnormalities. "
12/01/1996 - "The superactivity of 5-phosphoribosyl-pyrophosphate (PRPP) synthetase and deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) caused hyperuricemia. "
|1.||Uric Acid (Urate)
|4.||Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
|5.||Adenosine Triphosphate (ATP)
|7.||Ribose-Phosphate Pyrophosphokinase (Phosphoribosyl Pyrophosphate Synthetase)
|8.||Glutathione Reductase (Glutathione-Disulfide Reductase)
|2.||Drug Therapy (Chemotherapy)