Rhodamines

A family of 3,6-di(substituted-amino)-9-benzoate derivatives of xanthene that are used as dyes and as indicators for various metals; also used as fluorescent tracers in histochemistry.

Also Known As:

Networked: 466 relevant articles (7 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Urano, Yasuteru: 22 articles (04/2022 - 11/2006)
2.	Kamiya, Mako: 16 articles (04/2022 - 03/2007)
3.	Choyke, Peter L: 15 articles (11/2018 - 11/2006)
4.	Kobayashi, Hisataka: 15 articles (11/2018 - 11/2006)
5.	Hama, Yukihiro: 7 articles (08/2008 - 11/2006)
6.	Koyama, Yoshinori: 6 articles (11/2007 - 11/2006)
7.	Kuriki, Yugo: 5 articles (04/2022 - 01/2018)
8.	Lanza, Gregory M: 4 articles (01/2020 - 03/2011)
9.	Storm, Gert: 4 articles (02/2012 - 04/2011)
10.	Kosaka, Nobuyuki: 4 articles (11/2011 - 08/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2011 - "Microscopic studies revealed that the vascular constrained, rhodamine-labeled α(v)β(3)-GNBs homed specifically to immature neovasculature (PECAM(+), Tie-2(-)) along the immediate tumor periphery, but not to nearby mature microvasculature (PECAM(+), Tie-2(+)). " 01/01/2022 - "Obviously, an important role in these processes is played by the increased retention of rhodamines in tumor cells. " 01/01/2021 - "Upon activation by tumor-associated GGT, the probe releases highly fluorescent rhodamine that is selectively confined in tumors whereby light irradiation leads to effective tumor regression in mice. " 01/01/2021 - "We herein report a trifunctional probe (Glu-RdEB) that could be activated to generate fluorescent rhodamine species to pinpoint tumor foci. " 01/01/2021 - "With the strategy, a wide range of cancer cells/tissues, including surgical tissue specimens harvested from patients, were distinguished from normal ones by using a combination of β-Lap and a Si-rhodamine-based NIR fluorescent ROS probe PSiR3 developed in this work with average tumor-to-normal (T/N) ratios up to 15 in cell level and 24 in tissue level, far exceeding the clinically acceptable threshold of 2.0. "
2.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2011 - "A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. " 08/09/2016 - "Serial fluorescence imaging was performed using various concentrations of γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) which was sprayed on the peritoneal surface with tiny implants of SHIN3-DsRed ovarian cancer tumors. " 08/01/2008 - "Herein, we demonstrate that the rhodamine-fluorophore, TAMRA, is the most robust of the 4 common rhodamine fluorophores for in vivo optical imaging of ovarian cancer metastases to the peritoneum." 11/01/2006 - "While fluorescein demonstrated the highest signal outside the cell, among the four fluorophores, internalized Av-rhodamine green emitted the most light from SHIN3 ovarian cancer cells both in vitro and in vivo. " 11/13/2018 - "In this study two enzyme activatable probes, γ-glutamylhydroxymethyl rhodamine green (gGlu-HMRG) that reacted with γ-glutamyltransferase and SPiDER-βGal that reacted with β-galactosidase, were employed to determine the effects of temperature on fluorescence signal kinetics in both fresh and frozen and then thawed ex vivo experimental ovarian cancer tissue samples. "
3.	Phototoxic Dermatitis (Phototoxicity) 12/01/2021 - "Compared to the prototypical rhodamine-based Zn2+ probes, the new class exploits morpholino auxochromes which eliminates phototoxicity during long-term live recording of isolated islets. " 01/01/2017 - "The reaction of an N-hydroxysuccinimide (NHS) ester of rhodamine (Rho) and clinical Pro was carried out in this study to yield RhoPro, and a demonstration of its phototoxicity, wherein clinical Pro improved the effect of PDT, was performed. " 02/01/1996 - "Phototoxicity of some bromine-substituted rhodamine dyes: synthesis, photophysical properties and application as photosensitizers."
4.	Glioma (Gliomas) 01/01/2020 - "The uptake of vesicles by U87 glioma cells displayed that the cellular uptake of Ac4MAN-Rho-LIP (labeled by rhodamine) was remarkably improved, compared with Rho-LIP. " 01/01/2013 - "Using rhodamine-labeled NP and U251 glioma cell-derived xenografts, we demonstrated that the NP-TRAIL were found in the tumor site and induced a significant increase in glioma cell apoptosis, a decrease in tumor volume, and increased animal survival. " 01/01/2020 - "Rhodamine-conjugated SCNP analysis showed the internalization of silibinin to C6 glioma cells. " 08/01/2004 - "Most significantly, when Lissamine rhodamine-labeled MG11 peptide is injected intratumorally, it targets specifically to glioma xenografts instead of non-glioma-derived xenografts. " 01/01/2008 - "Permeability of rhodamine-labeled dendrimers and MTX-loaded dendrimers across the in vitro BBB model and their distribution into avascular human glioma tumor spheroids was also studied. "
5.	Hepatolenticular Degeneration (Wilson's Disease) 12/01/2004 - "Investigation regarding Wilson's disease gave positive results, since the use of rhodamine staining, which is specific to detect the presence of copper in tissues, resulted in red-brown grains at light microscopy. "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Esters
3.	1-phenyl-3,3-dimethyltriazene (PDT)
4.	N-hydroxysuccinimide
5.	Copper
6.	Ligands
7.	Argon
8.	Amides
9.	rhodamine B
10.	Hematoporphyrins

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Intraperitoneal Injections
3.	Precision Medicine
4.	Ligation
5.	Microspheres (Microsphere)