|1.||Asthma (Bronchial Asthma)
|5.||Seasonal Allergic Rhinitis (Hay Fever)
|1.||Ciprandi, Giorgio: 48 articles (12/2015 - 06/2003)|
|2.||Zhang, Luo: 42 articles (08/2015 - 03/2005)|
|3.||Passalacqua, Giovanni: 40 articles (01/2015 - 03/2003)|
|4.||Canonica, G W: 39 articles (01/2015 - 06/2000)|
|5.||Ciprandi, G: 36 articles (02/2015 - 06/2000)|
|6.||Passalacqua, G: 35 articles (02/2014 - 06/2000)|
|7.||Bousquet, J: 32 articles (08/2015 - 03/2000)|
|8.||Canonica, Giorgio Walter: 32 articles (07/2015 - 03/2003)|
|9.||Bousquet, Jean: 31 articles (05/2015 - 01/2004)|
|10.||Cheng, Lei: 29 articles (08/2015 - 01/2003)|
|1.||Adrenal Cortex Hormones (Corticosteroids)IBA
02/01/2010 - "Intranasal corticosteroids are the most effective treatment for allergic rhinitis based on meta-analyses of clinical trials; however, the population in such trials is restricted and may not be representative of patients who are later treated with the medication. "
07/01/2015 - "Intranasal corticosteroids are generally considered the most effective medication class for controlling allergic rhinitis. "
03/01/2014 - "Intranasal corticosteroids are the most effective medication class for controlling allergic rhinitis (AR) symptoms. "
11/01/2013 - "Guidelines from throughout the world recommend intranasal corticosteroids (INSs) as first-line treatment for most patients with moderate to severe allergic rhinitis. "
04/01/2009 - "Intranasal corticosteroids (INSs) are the most effective treatment for allergic rhinitis (AR). "
|2.||Histamine Antagonists (Antihistamines)IBA
12/01/1992 - "The older, classic antihistamines are effective in treating the symptoms of allergic rhinitis, but most are sedating because they cross the blood-brain barrier. "
12/01/2007 - "Oral antihistamines have proven efficacy in treating ocular symptoms of allergic rhinitis."
09/01/2001 - "In treating allergic rhinitis, the new second- and third-generation antihistamines have multiple advantages including rapid onset of action, extended duration of action, and efficacy for nearly all the symptoms that are produced by allergen sensitization. "
12/01/2007 - "Antihistamines are an established first-line treatment for allergic rhinitis and are widely prescribed in infants for allergic symptoms. "
04/01/2007 - "Intranasal and oral antihistamines are effective in treating allergic rhinitis. "
|3.||Immunoglobulin E (IgE)IBA
12/01/1992 - "Both products are highly effective in patients who have IgE-mediated allergic rhinitis but must be administered prophylactically before exposure to an allergen to prevent development of the allergic event. "
01/01/2012 - "Compound 22 significantly improved symptoms of allergic rhinitis and suppressed levels of total IgE of serum. "
03/01/1981 - "4. Mucous IgE levels are significantly greater in the allergic form than in the vasomotor form of rhinitis. "
12/01/2004 - "Remission of AR was defined as AR at baseline but no rhinitis symptoms at follow-up and sensitization (s-IgE level class > or =2 at baseline and class <2 at follow-up). "
12/01/2015 - "The aim of this study was to evaluate the component-resolved diagnosis using a microarray allergen chip (Immuno Solid-phase Allergen Chip, ImmunoCAP ISAC) and to compare this new diagnostic tool with the established ImmunoCAP methods for allergen-specific IgE detection in allergic rhinitis patients. "
|4.||azelastine (Optivar)FDA LinkGeneric
07/01/1987 - "Azelastine, already proven effective in allergic rhinitis, has a bronchodilator effect at doses that do not produce intolerable side effects."
07/01/2000 - "The analysis of the Rhinitis Severity Score showed significant improvement only of rhinorrhea in the azelastine group (P = .03). "
04/01/2015 - "Other agents effective in treating nonallergic rhinitis (NAR) such as azelastine have been demonstrated to exhibit TRPV1 channel activity through the modulation of Ca(2+) signaling on sensory neurons and in nasal epithelial cells. "
03/01/1997 - "Azelastine is a topical antihistamine, clinically demonstrated to be effective in allergic rhinitis. "
02/01/1997 - "Azelastine is a selective H1-receptor antagonist, which has previously been demonstrated to be effective in the treatment of allergic rhinitis. "
11/01/2003 - "Although topical nasal steroids are useful in the treatment of all forms of rhinitis, diagnosis of the offending type in a given patient is necessary for optimal management."
03/01/1999 - "First-line use of intranasal steroids is becoming increasingly common, and intranasal steroids can be used alone or in combination with other therapies to achieve optimal improvement in rhinitis symptoms. "
03/01/2001 - "Topical nasal steroids have been found beneficial in a variety of acute and chronic nasal conditions including allergic and nonallergic rhinitis and chronic rhinosinusitis. "
10/01/2007 - "BHR "remission" was more frequent in patients with rhinitis treated by nasal steroids than in those not treated (OR [95% CI], 0.33 [0.14-0.75]). "
05/01/2006 - "Intranasal steroids (INSs) are recommended as first-line treatment for allergic rhinitis (AR) and a wealth of data exist supporting them as safe and effective. "
|6.||Cetirizine (Zyrtec)FDA LinkGeneric
12/01/1995 - "It is concluded that the amount of sulfidoleukotrienes produced by blood leukocytes in vitro may reflect the nasal hyperreactivity of the patient, and that cetirizine, which is highly effective in the treatment of allergic rhinitis, owes part of its effect to inhibition of sulfidoleukotriene releasability by blood leukocytes in children."
05/01/1995 - "Placebo-treated patients experienced a worsening of rhinitis symptoms from baseline throughout the study, whereas cetirizine-treated patients had a significant improvement in rhinitis symptoms at week 1, which was maintained after onset of the pollen season. "
08/01/1996 - "After 6 weeks of treatment, percentage of days without rhinitis or with only mild rhinitis symptoms was significantly greater in the cetirizine group in comparison with the placebo group (p < 0.0001, Mann-Whitney U test). "
01/01/1992 - "Cetirizine was significantly more effective than placebo in reducing the clinical symptoms of rhinitis near in 60% patients. "
04/01/1995 - "The efficacy of cetirizine was compared with that of previous pharmacologic therapy in patients with allergic rhinitis. "
|7.||montelukast (Singulair)FDA Link
02/01/2003 - "The treatment effect of montelukast was significantly greater (P < 0.05), relative to placebo, for all secondary endpoints, including nighttime symptoms and daytime eye symptoms, patient and physician global evaluations of allergic rhinitis, and rhinoconjunctivitis quality of life. "
12/01/2005 - "Montelukast treatment also improved global evaluations of allergic rhinitis by patients and Rhinoconjunctivitis Quality of Life Questionnaire scores: differences vs the placebo group were -0.15 (95% CI, -0.27 to -0.04; P < .01) and -0.15 (95% CI, -0.24 to -0.06; P < .001), respectively. "
06/01/2006 - "Recent studies have demonstrated that montelukast is also effective in treating daytime and nighttime allergic rhinitis (AR) symptoms in asthmatic patients. "
03/01/2014 - "This study investigated improvements in quality of life associated with eight weeks of montelukast and/or intranasal steroid treatment for moderate to severe allergic rhinitis. "
12/01/2013 - "This study tested inhibitory effects of in vitro Montelukast treatment on nasal airway epithelial cells (AEC) cultured from asthmatic patients treated with Montelukast with and without concomitant allergic rhinitis. "
|8.||fluticasone (Cutivate)FDA LinkGeneric
01/01/2000 - "The most commonly prescribed nasal steroid, fluticasone, has been shown to be effective in treating rhinitis and in improving patients' quality of life. "
03/01/1997 - "Fluticasone propionate is a fluorinated steroid reported to be highly effective when used topically in the nose for seasonal and perennial allergic and nonallergic rhinitis. "
05/01/1997 - "The intranasal corticosteroid fluticasone propionate is an effective agent for the treatment of rhinitis, demonstrating potent local anti-inflammatory activity and little, if any, systemic activity. "
03/01/2001 - "The study suggests that fluticasone propionate nasal spray can be beneficial in the treatment of patients with rhinitis medicamentosa."
02/01/1996 - "Fluticasone propionate aqueous nasal spray: a well-tolerated and effective treatment for children with perennial rhinitis."
01/01/2013 - "However, there are now many meta-analyses, systematic reviews and high-quality clinical trials that find overwhelmingly in favor of the efficacy of allergen immunotherapy (including sublingual formulations) in allergic rhinitis induced by pollen and, increasingly, other allergens. "
09/01/2004 - "A skin prick test with relevant allergens was performed on those aged 6 to 15 years: 61.8% had positive results to one or more allergens, compared to 23.75% in a non-rhinitis control group. "
06/01/2015 - "To investigate the efficacy of a novel temperature and humidity machine to control the level of dust mite allergens and total nasal symptom score (TNSS) in dust mite sensitized allergic rhinitis children. "
12/22/2014 - "Twenty-one patients with allergic rhinitis (AR) were included on the basis of a positive history of AR symptoms and positive results of skin prick tests to grass pollen allergens. "
09/01/2013 - "Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). "
|10.||Histamine (Histamine Dihydrochloride)FDA Link
06/01/1998 - "Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonallergic noninfectious perennial rhinitis."
01/01/1994 - "The results of our investigation demonstrated that histamine might cause the number of CD4 and CD8 cells into disorder in allergic nasal mucosal epithelium and the H2 antagonist may be useful in the treatment of allergic rhinitis."
01/01/1988 - "[Comparison of the efficacy of two H2 antagonists of histamine in allergic rhinitis. "
01/01/2014 - "Add-on histamine receptor-3 antagonist for allergic rhinitis: a double blind randomized crossover trial using the environmental exposure unit."
11/01/2011 - "The present study was designed to investigate CBF in the acute phase of allergic rhinitis and the effect of histamine on CBF. "
02/01/2000 - "Most authors consider immunotherapy as an efficient and safe treatment for pollen and mite allergic rhinitis. "
01/01/2010 - "This updated review reinforces the conclusion of the original 2003 Cochrane Review that sublingual immunotherapy is effective for allergic rhinitis and has been proven to be a safe route of administration."
04/01/2007 - "There is strong evidence that sublingual immunotherapy is effective in allergic rhinitis in adults. "
07/01/1996 - "Controlled ragweed pollen exposure in this setting demonstrated that ragweed immunotherapy significantly reduced symptoms of ragweed-allergic rhinitis but had no significant effect on ocular symptoms. "
01/01/2011 - "Sublingual immunotherapy (SLIT) was introduced in the 1990s as a possible solution to the problem of adverse systemic reactions to subcutaneous immunotherapy and has been demonstrated by more than 50 trials and globally evaluated thus far by five meta-analyses as an effective and safe treatment for allergic rhinitis. "
|2.||Drug Therapy (Chemotherapy)
06/01/2000 - "Effective treatment of adults with allergic rhinitis usually requires an integrated regimen that combines allergen avoidance measures, pharmacotherapy, and possible specific-allergen immunotherapy. "
05/01/1995 - "Carefully chosen pharmacotherapy based on an understanding of the pathophysiology of the disease, knowledge of the potential of medications, and commitment to an ongoing patient/physician education and monitoring program can lead to improved well-being for individuals with perennial rhinitis."
02/01/1998 - "This article provides guidelines for pharmacotherapy to maximize symptom relief from allergic rhinitis. "
01/01/2013 - "The objective of the present study was to analyse modern concepts of pathogenesis od local immune changes in nasal mucosa associated with allergic rhinitis (AR)and the currently available methods for rational pharmacotherapy of this condition. "
12/30/2001 - "Methods are illustrated and compared in two randomized clinical trials which involve recurrences of severe adverse events following chemotherapy in 938 patients with chronic lymphocytic leukaemia, and recurrences of infectious rhinitis episodes in 327 patients. "
06/01/2011 - "It has been shown to be effective in the reduction of allergic rhinitis symptoms in both children and adults, with effects being sustained for several years after treatment completion. "
12/01/2014 - "SLIT was effective in 85% of children with allergic rhinitis one after treatment vs 100% two years after treatment. "
01/01/2014 - "Thus, the aim of this study was to investigate whether attention performance was improved after treatment in children with allergic rhinitis. "
05/01/2014 - "The clinical efficacy of allergic rhinitis and rhinoconjunctivitis quality of life questionnaire (RQLQ) score were observed before and after treatment as well as in the 4-weeks follow-up after the end of treatment respectively. "
10/01/2009 - "Sleep actigraphy evidence of improved sleep after treatment of allergic rhinitis."
|4.||Phototherapy (Light Therapy)
05/08/2005 - "These results suggest that intranasal phototherapy is effective for the treatment of allergic rhinitis, and opens up new opportunities for the treatment of immune-mediated mucosal diseases."
03/01/2005 - "We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis. "
12/01/2011 - "There are emerging reports on the efficacy of intranasal phototherapy in allergic rhinitis. "
07/01/2015 - "Efficacy of endonasal phototherapy for relieving the symptoms of allergic rhinitis: Meta-analysis."
12/01/2009 - "We aimed to investigate the efficacy of phototherapy in improving the quality of life of patients with allergic rhinitis using Rhinoconjunctivitis Quality of Life Questionnaire, besides checking the total symptom scores of 100 consecutive cases. "
06/01/2012 - "Intranasal administration is a non-invasive route for drug delivery, which is widely used for the local treatment of rhinitis or nasal polyposis. "
01/01/2012 - "An antagonist for CCR4 alleviates murine allergic rhinitis by intranasal administration."
10/01/2011 - "Intranasal administration of CD30-Ig during the effector phase with OVA significantly prevented the development of allergic rhinitis in WT mice. "
04/14/2011 - "The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis."
03/01/2007 - "Needleless intranasal administration of HVJ-E containing allergen attenuates experimental allergic rhinitis."