Rheumatoid Nodule

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160 relevant articles (3 outcomes, 11 trials/studies) found for this Disease

Description: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.

Also Known As:

Nodule, Rheumatoid; Nodules, Rheumatoid; Rheumatoid Nodules

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 83

Rheumatic Diseases: 4767

Rheumatoid Arthritis: 27065

Rheumatoid Nodule: 160

Joint Diseases: 1496

Arthritis: 14058

Rheumatoid Arthritis: 27065

Rheumatoid Nodule: 160

Skin and Connective Tissue Diseases

Connective Tissue Diseases: 1625

Rheumatic Diseases: 4767

Rheumatoid Arthritis: 27065

Rheumatoid Nodule: 160

Related Diseases

1.	Pain (Aches)
2.	Felty's Syndrome (Syndrome, Felty's)
3.	Rheumatoid Arthritis
4.	Necrosis
5.	Syndrome
79 Diseases and 77 more articles analyzed in the Research Interface, order at left...

Experts

1.	Criswell, Lindsey A: 1 article (03/2004)
2.	Goral, A: 1 article (03/2001)
3.	Guntinas-Lichius, O: 1 article (11/2000)
4.	Knoess, M: 1 article (01/2008)
5.	Kato, H: 1 article (08/2000)
6.	Davis, W Hodges: 1 article (01/2003)
7.	Kriegsmann, J: 1 article (01/2008)
8.	Baeten, D: 1 article (05/2004)
9.	Norton, Jim: 1 article (01/2003)
10.	Pap, Thomas: 1 article (03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rheumatoid Nodule:

1.	infliximab (Remicade)FDA Link 12/01/2004 - "One year after the initiation of infliximab, with RA in remission, our patient noted the rapid development of rheumatoid nodules of both hands" 05/01/2004 - "CONCLUSIONS: Despite an improvement of articular symptoms, infliximab treatment had no distinct effect on the histopathology of rheumatoid nodules, suggesting that different pathogenetic mechanisms mediate the two disease manifestations in RA." 05/01/2004 - "OBJECTIVE: To analyse the effect of infliximab on the immunopathology of rheumatoid nodules in order to provide new insights into the relationship between synovial inflammation and rheumatoid nodules" 05/01/2004 - "Tumour necrosis factor alpha independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules." Get all the results and reference details, order at left...
2.	LatexIBA 01/01/1988 - "16/24 patients with so-called seronegative RA (negative Latex Fixation Test or Waaler Rose Test) had positive results in the ELISA, two of them had rheumatoid nodules clinically" 07/01/1980 - "The males seem to have more severe disease with positive latex fixation, radiographic changes and rheumatoid nodules than is reported in the literature and the female comparison population" 02/01/1987 - "None of the variables studied--age and calendar year of disease onset, pattern of joint involvement, the presence of rheumatoid nodules, Sjögren's syndrome, a positive latex or antinuclear antibody (ANA) titre--showed a greater concordance within the families than between them" Get all the results and reference details, order at left...
3.	rituximab (Mabthera)FDA Link 07/01/2008 - "We report the case of a 60-year-old man with Felty's syndrome in whom treatment with rituximab led to a sustained neutrophil response and marked symptomatic improvement in the form of decrease in the size of rheumatoid nodules and better pain control." Get all the results and reference details, order at left...
4.	CortisoneIBA 07/01/1951 - "A histopathologic study of the involution of rheumatoid nodules treated with cortisone and of spontaneous involution." 07/01/1952 - "Effect of cortisone on rheumatoid nodules of the sclera (scleromalacia perforans)." 11/01/1951 - "The involution of rheumatoid nodules treated with cortisone and of non-treated rheumatoid nodules." 05/01/1951 - "Cortisone therapy in case of rheumatoid nodules of the eye in chronic rheumatoid arthritis." 02/01/1952 - "Rheumatoid nodules a study in the pathogenesis and effects of cortisone and ACTH." Get all the results and reference details, order at left...
5.	Adrenocorticotropic Hormone (ACTH)FDA Link 02/01/1952 - "Rheumatoid nodules a study in the pathogenesis and effects of cortisone and ACTH." 09/01/1951 - "Rheumatoid nodules; a study in their pathogenesis and the effects of cortisone and ACTH." Get all the results and reference details, order at left...
6.	Antinuclear AntibodiesIBA 01/01/2000 - "Extra-articular disease was predicted by the demonstration of antinuclear antibodies (Odds ratio (OR) 3.6; 95% CI: 1.4-9.1) and the presence of rheumatoid nodules within two years from RA diagnosis (OR 3.4; 95%, CI: 1.1-10.9) or at any time before ExRA onset (OR 2.8; 95% CI: 1.1-7.2)" 01/01/1997 - "This report describes a 3-year-old girl with RF-negative, antinuclear antibody-negative systemic JRA who developed multiple rheumatoid nodules on the scalp and trunk during MTX therapy" 01/01/2000 - "CONCLUSION: Extra-articular manifestations of rheumatoid arthritis in a hospital based population were predicted by antinuclear antibodies and rheumatoid nodules." 01/01/1996 - "No significant relationships were found between the skeletal, extraskeletal or familial features of AS or RA (iritis, psoriasis, inflammatory enteropathy and rheumatoid nodules, kerato-conjunctivitis sicca, pleuritis, rheumatoid and antinuclear factors) and the overall genotype" 02/01/1987 - "None of the variables studied--age and calendar year of disease onset, pattern of joint involvement, the presence of rheumatoid nodules, Sjögren's syndrome, a positive latex or antinuclear antibody (ANA) titre--showed a greater concordance within the families than between them" Get all the results and reference details, order at left...
7.	AntibodiesIBA 02/01/2004 - "In RA complicated by extraarticular manifestations, anti-GPI antibodies were observed in 18% of patients with rheumatoid nodules, 45% of patients with rheumatoid vasculitis, and 92% of patients with Felty's syndrome" 04/01/2006 - "Some studies, however, suggest that there is a correlation present between those antibodies and C-reactive protein levels, rheumatoid nodules, and antinuclear antibodies" 05/01/1988 - "The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components" 05/01/1984 - "The histochemical demonstration of acid phosphatase (ACP) and adenosine triphosphatase (ATP) has been combined with standard immunofluorescence techniques, using a panel of monoclonal and conventional antibodies, to examine lymphocyte and macrophage subsets and their microanatomical relationships within the subcutaneous rheumatoid nodule (RN)" Get all the results and reference details, order at left...
8.	Complement System Proteins (Complement)IBA 08/01/2000 - "Complement mediated vascular endothelial injury in rheumatoid nodules: a histopathological and immunohistochemical study." 01/01/2008 - "Colocalization of C4d deposits/CD68+ macrophages in rheumatoid nodule and granuloma annulare: immunohistochemical evidence of a complement-mediated mechanism in fibrinoid necrosis." 11/01/1978 - "Complement-fixing hidden rheumatoid factor in children with benign rheumatoid nodules." Get all the results and reference details, order at left...
9.	C-Reactive ProteinIBA 01/01/1987 - "Disease duration below 5 and above 5 years resulted in further division of each group into subgroups 1 and 2. With few exceptions, there were no significant differences between the groups in terms of maximal articular index, lymphadenopathy, splenomegaly, hepatomegaly, frequency of rheumatoid nodules and lowest hematocrit, highest erythrocyte sedimentation rate, and C-reactive protein values" 04/01/2006 - "Some studies, however, suggest that there is a correlation present between those antibodies and C-reactive protein levels, rheumatoid nodules, and antinuclear antibodies" 03/01/1996 - "We identified individual factors associated with worse outcome: presence of serum rheumatoid factor (RF), HLA-DR4, signs of high disease activity [number of swollen or tender joints, elevated C-reactive protein (CRP)], rheumatoid nodules, radiological abnormalities, poor grip strength, and poor functional status" Get all the results and reference details, order at left...
10.	Interleukin-2 (IL2)IBA 09/01/1997 - "OBJECTIVE: To study at a molecular level the clonality of interleukin 2 (IL-2) expanded T cell lines derived from rheumatoid nodules" 07/01/1993 - "We expanded T lymphocytes from human rheumatoid nodules by IL-2 stimulation and observed a marked oligoclonality among these expanded lymphocytes" 09/01/1997 - "METHODS: T cell lines were derived from rheumatoid nodules in 2 patients with rheumatoid arthritis (RA) and expanded in medium containing IL-2" 09/01/1997 - "CONCLUSION: Molecular analysis of TCR rearrangements in IL-2 expanded T cell lines from rheumatoid nodules strongly suggests that in situ T cell activation is related to classical antigen induced immune activation." 07/01/1993 - "T cell receptor V beta usage in rheumatoid nodules: marked oligoclonality among IL-2 expanded lymphocytes." Get all the results and reference details, order at left...
105 Drugs and Important Bio-Agents and 149 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/2005 - "CONCLUSION: The baseline presence of RF by either Waaler-Rose or nephelometry was not associated with differences in drug therapy, morbidity other than rheumatoid nodules, or mortality in RA patients in the first 5 years of disease" 01/01/2003 - "The influence of rheumatoid chemotherapy, age, and presence of rheumatoid nodules on postoperative complications in rheumatoid foot and ankle surgery: analysis of 725 procedures in 104 patients [corrected]." Get all the results and reference details, order at left...
2.	Arthroplasty 05/01/1993 - "Rheumatoid nodules at the cement-bone interface in revision arthroplasty of rheumatoid patients." 08/01/1986 - "Four operations have to be considered for the rheumatoid elbow: removal of rheumatoid nodules and bursectomy, resection of the radial head, synovectomy, and arthroplasty" Get all the results and reference details, order at left...
3.	Transurethral Resection of Prostate (TURP) 03/01/1984 - "This distinctive histologic lesion strongly resembles a rheumatoid nodule, but is not associated with connective tissue disease or infection and is probably related to prior transurethral prostatectomy or needle biopsy." Get all the results and reference details, order at left...
4.	Bronchoscopes 11/01/1998 - "Rheumatoid nodule diagnosed by thoracoscopy using flexible fiberoptic bronchoscope]" Get all the results and reference details, order at left...
5.	Prostheses and Implants (Prosthesis) 10/01/1994 - "In each case, rheumatoid nodules developed on the amputation stump, causing difficulties with prosthesis fit and comfort and impairment of ambulation" Get all the results and reference details, order at left...
11 Therapies and Procedures and 12 more articles analyzed in the Research Interface, order at left...

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