Rheumatic Nodule

A small round or oval, mostly subcutaneous nodule made up chiefly of a mass of Aschoff bodies and seen in cases of rheumatic fever. It is differentiated from the RHEUMATOID NODULE which appears in rheumatoid arthritis, most frequently over bony prominences. (From Dorland, 27th ed)

Also Known As:

Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Myocarditis (Carditis)
2.	Rheumatic Heart Disease (Rheumatic Heart Diseases)
3.	Neoplasms (Cancer)
4.	Necrosis
5.	Plasma Cell Granuloma

Experts

1.	Armada, Mariana: 1 article (01/2022)
2.	Bianchi, María L: 1 article (01/2022)
3.	Citera, Gustavo: 1 article (01/2022)
4.	Ferrary, Teresita: 1 article (01/2022)
5.	González, Débora A: 1 article (01/2022)
6.	Isnardi, Carolina A: 1 article (01/2022)
7.	Orman, Betina: 1 article (01/2022)
8.	Salgado, Pablo A: 1 article (01/2022)
9.	Seni, Sabrina: 1 article (01/2022)
10.	Adsay, Volkan: 1 article (07/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rheumatic Nodule:

1.	ParaffinIBA 02/01/1992 - "Immunohistochemical and histochemical profile of Aschoff bodies in rheumatic carditis in excised left atrial appendages: an immunoperoxidase study in fresh and paraffin-embedded tissue."
2.	C-Reactive ProteinIBA 11/01/1955 - " I. Lack of correlation between C-reactive protein and Aschoff bodies in left auricular appendage biopsies." 07/01/2022 - "Here we report on a case of a 59-year-old woman with mixed aortic and mitral valve disease of probable rheumatic aetiology (elevated C-reactive protein and prolonged PR interval) and with histological evidence of lymphocytic infiltration, Aschoff bodies, and fibrinoid necrosis admixed with features of chronic RHD. " 01/01/2022 - "RA clinical parameters (disease duration, erythrocyte sedimentation rate, serum C-reactive protein, disease activity (DAS28) and rheumatoid factor, presence of bone erosions and rheumatic nodules) and also corticosteroid therapy were considered. " 08/01/2014 - "Compared with the control group, Rhupus patients had a longer disease duration, higher prevalence of anticyclic citrullinated peptide antibody and rheumatoid factor, higher incidence of symmetrical polyarthritis with more joint deformities and rheumatic nodules, and increased erythrocyte sediment rate and c-reactive protein levels (P < 0.005). "
3.	Rheumatoid FactorIBA 01/01/2017 - "Its main risk factor is the occurrence of rheumatic nodules in people with the presence of serum rheumatoid factor. " 01/01/2022 - "RA clinical parameters (disease duration, erythrocyte sedimentation rate, serum C-reactive protein, disease activity (DAS28) and rheumatoid factor, presence of bone erosions and rheumatic nodules) and also corticosteroid therapy were considered. " 08/01/2014 - "Compared with the control group, Rhupus patients had a longer disease duration, higher prevalence of anticyclic citrullinated peptide antibody and rheumatoid factor, higher incidence of symmetrical polyarthritis with more joint deformities and rheumatic nodules, and increased erythrocyte sediment rate and c-reactive protein levels (P < 0.005). "
4.	Methotrexate (Mexate)FDA LinkGeneric 06/01/1998 - "As methotrexate is used increasingly in the treatment of rheumatoid arthritis and as this particular drug causes rheumatic nodules in five to 10 per cent of the patients, it must be foreseen that the incidence of nodules in the upper airways will increase." 12/01/1996 - "Gastrointestinal complications are the most common adverse effects of methotrexate, but hepatotoxicity, haematological toxicity, pulmonary toxicity, lymphoproliferative disorders and exacerbation of rheumatic nodules have all been reported. " 11/20/1994 - "A 58-year-old woman with chronic polyarthritis rapidly developed a large number of rheumatic nodules under treatment with methotrexate. " 11/20/1994 - "Although the predominantly anti-inflammatory actions of methotrexate control the chronic polyarthritis in almost all cases so far reported, they are unable to prevent the primarily immunological tissue necrosis (rheumatic nodules) and may even promote their development through the liberation of adenosine. "
5.	Amyloid (Amyloid Fibrils)IBA 01/01/2016 - "Amyloid and Aschoff bodies are uncommon and the rest of the changes are uniformly distributed across both the atria." 07/01/1996 - "Rarer diseases such as amyloid tumors, rheumatic nodules and plasma-cell granulomas can be the cause of this finding. " 02/01/1996 - "Rarer diseases such as amyloid tumors, rheumatic nodules, and plasma-cell granulomas can, depending on the clinical situation, be the cause of this finding. "
6.	EnzymesIBA 07/01/1988 - "Perhaps histiocytes that form Aschoff bodies do not express this lysosomal enzyme. " 07/01/2019 - "These circulating enzymes, especially lipase, exerts its digestive action on other tissues, especially on the subcutaneous tissues in the pressure poins of legs, creating a picture often mistaken as erythema nodosum or rheumatic nodules. "
7.	LectinsIBA 07/01/1988 - "Proliferative Aschoff bodies in heart sections from 6 patients with acute rheumatic heart disease were tested by avidin-biotin peroxidase labeling methods for the presence of desmin, muscle-specific actin, S-100, neurofilament, leukocyte common antigen, receptor for Ulex europeus I lectin, Factor VIII-related antigen, vimentin, alpha 1-antichymotrypsin, and myeloid/histiocyte antigen. "
8.	Leukocyte Common Antigens (CD45 Antigen)IBA 07/01/1988 - "Proliferative Aschoff bodies in heart sections from 6 patients with acute rheumatic heart disease were tested by avidin-biotin peroxidase labeling methods for the presence of desmin, muscle-specific actin, S-100, neurofilament, leukocyte common antigen, receptor for Ulex europeus I lectin, Factor VIII-related antigen, vimentin, alpha 1-antichymotrypsin, and myeloid/histiocyte antigen. "
9.	von Willebrand FactorIBA 07/01/1988 - "Proliferative Aschoff bodies in heart sections from 6 patients with acute rheumatic heart disease were tested by avidin-biotin peroxidase labeling methods for the presence of desmin, muscle-specific actin, S-100, neurofilament, leukocyte common antigen, receptor for Ulex europeus I lectin, Factor VIII-related antigen, vimentin, alpha 1-antichymotrypsin, and myeloid/histiocyte antigen. "
10.	VimentinIBA 07/01/1988 - "Proliferative Aschoff bodies in heart sections from 6 patients with acute rheumatic heart disease were tested by avidin-biotin peroxidase labeling methods for the presence of desmin, muscle-specific actin, S-100, neurofilament, leukocyte common antigen, receptor for Ulex europeus I lectin, Factor VIII-related antigen, vimentin, alpha 1-antichymotrypsin, and myeloid/histiocyte antigen. "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "RA clinical parameters (disease duration, erythrocyte sedimentation rate, serum C-reactive protein, disease activity (DAS28) and rheumatoid factor, presence of bone erosions and rheumatic nodules) and also corticosteroid therapy were considered. "