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Retinaldehyde (Retinal)

A diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.
Also Known As:
Retinal; Retinene; Vitamin A Aldehyde; 11-cis-Retinal; 11 cis Retinal; 11 trans Retinal; Aldehydde, Retinyl; Aldehyde, Vitamin A; all trans Retinal; 11-trans-Retinal; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal; Axerophthal; Retinyl Aldehydde; all-trans-Retinal
Networked: 50138 relevant articles (1606 outcomes, 5733 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Wong, Tien Yin: 229 articles (10/2022 - 01/2002)
2. Wong, Tien Y: 183 articles (10/2022 - 11/2003)
3. Klein, Ronald: 176 articles (01/2022 - 01/2002)
4. Mitchell, Paul: 146 articles (09/2022 - 10/2002)
5. Bandello, Francesco: 143 articles (12/2022 - 12/2002)
6. Wang, Jie Jin: 127 articles (01/2021 - 10/2002)
7. Freund, K Bailey: 125 articles (12/2022 - 08/2002)
8. Weinreb, Robert N: 123 articles (11/2022 - 01/2002)
9. Shields, Carol L: 121 articles (12/2022 - 03/2002)
10. Yoshimura, Nagahisa: 117 articles (01/2021 - 02/2002)

Related Diseases

1. Diabetic Retinopathy (Retinopathy, Diabetic)
2. Ischemia
3. Inflammation (Inflammations)
4. Glaucoma
5. Macular Degeneration (Age-Related Maculopathy)

Related Drugs and Biologics

1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2. Bevacizumab (Avastin)
3. Oxygen (Dioxygen)
4. Ranibizumab (Lucentis)
5. Biomarkers (Surrogate Marker)
6. Fluorescein (Funduscein)
7. Steroids
8. Proteins (Proteins, Gene)
9. Dexamethasone (Maxidex)
10. aflibercept

Related Therapies and Procedures

1. Therapeutics
2. Lasers (Laser)
3. Light Coagulation
4. Vitrectomy
5. Intravitreal Injections