Restless Legs Syndrome (Restless Legs)

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500 relevant articles (56 outcomes, 111 trials/studies) found for this Disease

Description: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. This condition may be associated with UREMIA; DIABETES MELLITUS; and rheumatoid arthritis. Restless Legs Syndrome differs from NOCTURNAL MYOCLONUS SYNDROME in that in the latter condition the individual does not report adverse sensory stimuli and it is primarily a sleep-associated movement disorder. (Adams et al., Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736)

Also Known As:

Restless Legs; Ekbom's Syndrome; Ekboms Syndrome; Syndrome, Ekbom; Syndrome, Ekbom's; Ekbom Syndrome

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3422

Sleep Disorders: 654

Parasomnias: 39

Restless Legs Syndrome: 500

Dyssomnias: 8

Intrinsic Sleep Disorders: 6

Restless Legs Syndrome: 500

Mental Disorders: 1709

Sleep Disorders: 654

Parasomnias: 39

Restless Legs Syndrome: 500

Dyssomnias: 8

Intrinsic Sleep Disorders: 6

Restless Legs Syndrome: 500

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Restless Legs Syndrome (Restless Legs)
3.	Pain (Aches)
4.	Sleep Initiation and Maintenance Disorders (Insomnia)
5.	Paresthesia (Dysesthesia)

Experts

1.	Trenkwalder, Claudia: 17 articles (08/2008 - 01/2002)
2.	Stiasny-Kolster, Karin: 11 articles (08/2008 - 01/2004)
3.	Allen, Richard P: 11 articles (06/2008 - 11/2002)
4.	Kohnen, Ralf: 9 articles (07/2008 - 10/2003)
5.	Earley, Christopher J: 9 articles (06/2008 - 05/2004)
6.	Paulus, Walter: 7 articles (08/2008 - 09/2004)
7.	Oertel, Wolfgang H: 7 articles (07/2008 - 01/2004)
8.	Happe, Svenja: 7 articles (05/2008 - 01/2003)
9.	Trenkwalder, C: 7 articles (10/2006 - 05/2001)
10.	Högl, Birgit: 6 articles (08/2008 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Restless Legs Syndrome:

1.	ropinirole (Requip)FDA Link 09/01/2006 - "Based on the results of randomized, placebo-controlled, double-blind trials, we conclude that ropinirole is effective in reducing symptoms of restless legs syndrome in the general population" 10/01/2006 - "Ropinirole is effective in the long-term management of restless legs syndrome: a randomized controlled trial." 12/01/2004 - "Ropinirole is effective in the treatment of restless legs syndrome" 10/01/2006 - "The objective of this study was to investigate the long-term efficacy of ropinirole in patients with restless legs syndrome (RLS) and to assess the potential for relapse after the discontinuation of active treatment" 08/01/2004 - "STUDY OBJECTIVES: Polysomnographic study evaluating the efficacy of ropinirole for the treatment of patients with restless legs syndrome (RLS) suffering from periodic leg movements in sleep (PLMS)" Order ALL the reference details at left...
2.	Dopamine Agonists (Dopamine Agonist)IBA 09/01/2004 - "BACKGROUND: Controlled clinical trials robustly demonstrate the short-term efficacy of dopamine agonists (DA) for restless legs syndrome (RLS), but little is known about the long-term efficacy and long-term adverse events" 12/01/2005 - "Evidence-based and clinical guidelines identify dopamine agonists as a first-line treatment for daily restless legs symptoms, and such substances are in the process of registration for this indication" 09/01/2008 - "STUDY OBJECTIVES: To define which leg movements (LM) associated with restless legs syndrome (RLS) respond to dopamine-agonist treatment and verify if they fall within current diagnostic criteria for periodic LM during sleep (PLMS)" 05/01/2008 - "PURPOSE: We performed a meta-analysis of randomized placebo-controlled trials of nonergot dopamine agonists (NEDAs) for the treatment of restless legs syndrome" 12/01/2005 - "This review discusses treatment studies of dopamine agonists in patients with restless legs syndrome and focuses on long-term treatment with dopamine agonists." Order ALL the reference details at left...
3.	Levodopa (L Dopa)FDA LinkGeneric 11/01/2007 - "OBJECTIVES: Levodopa is effective in the treatment of restless legs syndrome (RLS)" 01/01/2007 - "The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa treatment indicates RLS is caused by a dopaminergic abnormality" 12/15/1999 - "Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial." 01/15/1999 - "A controlled study of additional sr-L-dopa in L-dopa-responsive restless legs syndrome with late-night symptoms." 01/01/1999 - "An overview of levodopa in the management of restless legs syndrome in a dialysis population: pharmacokinetics, clinical trials, and complications of therapy." Order ALL the reference details at left...
4.	pramipexol (pramipexole)FDA LinkGeneric 01/20/2007 - "Fifty-one patients suffering from idiopathic restless legs syndrome underwent monotherapy with pramipexole in daily doses of 0.25 to 1.0 mg. Therapeutic efficacy was evaluated using three tools, i.e" 01/15/2007 - "Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-RLS study)." 03/23/1999 - "Restless legs syndrome improved by pramipexole: a double-blind randomized trial." 08/01/2007 - "First night efficacy of pramipexole in restless legs syndrome and periodic leg movements." 01/15/2007 - "We evaluated the efficacy of pramipexole versus placebo in restless legs syndrome (RLS) for 6 weeks" Order ALL the reference details at left...
5.	Pergolide (Permax)FDA Link 09/15/1998 - "Thus, although pergolide at the dose of 0.25 mg at bedtime provided subjective improvement in symptoms of restless legs and quality of sleep, and objectively decreased leg movements during the first hour in bed, objectively sleep continued to be disrupted" 04/27/2004 - "OBJECTIVE: To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study)" 04/27/2004 - "Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study." 12/01/1998 - "OBJECTIVE: To assess the efficacy of pergolide in the treatment of restless legs syndrome (RLS)" 05/22/2001 - "An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year" Order ALL the reference details at left...
6.	cabergoline FDA LinkGeneric 05/01/2000 - "STUDY OBJECTIVES: To define the effective dose of cabergoline and to evaluate the tolerability and efficacy of cabergoline in patients with restless legs syndrome (RLS)" 09/26/2006 - "Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR)." 06/15/2004 - "STUDY OBJECTIVES: To assess the safety and efficacy of cabergoline in the treatment of idiopathic restless legs syndrome (RLS) patients" 06/15/2004 - "Long-term safety and efficacy of cabergoline for the treatment of idiopathic restless legs syndrome: results from an open-label 6-month clinical trial." 07/01/2002 - "Work from our group and others have also demonstrated the efficacy of cabergoline in PD patients with nocturnal disabilities and those with restless legs syndrome (RLS)" Order ALL the reference details at left...
7.	Iron (Serum Iron Level)IBA 05/01/2004 - "BACKGROUND AND PURPOSE: To evaluate the safety and efficacy of a single 1000 mg iron infusion in treating Restless Legs Syndrome (RLS)" 12/01/2002 - "Increased activity during the period of IDA raises the issue of a shared underlying mechanism with restless legs syndrome, a sensorimotor dysfunction where iron deficiency increases the severity of the symptoms and iron supplementation ameliorates them" 09/01/1993 - "Improvement in symptoms of restless legs was noted with iron repletion" 06/01/2008 - "OBJECTIVE: Studies using cerebrospinal fluid, magnetic resonance imaging, and autopsy tissue have implicated a primary role for brain iron insufficiency in restless legs syndrome (RLS)" 03/01/2008 - "Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome" Order ALL the reference details at left...
8.	Opioid Analgesics (Opioids)IBA 04/01/2005 - "Opioids have been shown to provide symptomatic relief from dysaesthesias and motor symptoms in restless legs syndrome (RLS)" 07/01/2002 - "BACKGROUND AND PURPOSE: Therapeutic studies of the opioids in restless legs syndrome (RLS) are reviewed" 11/01/2001 - "The medical records of 493 patients with restless legs syndrome (RLS) from three major centers were studied to determine the number and outcome of patients who had been treated with opioids as a monotherapy" 11/01/2001 - "Long-term follow-up on restless legs syndrome patients treated with opioids." 03/01/1989 - "Other researchers have noticed the beneficial effect of opioids in the treatment of the restless legs syndrome (3)" Order ALL the reference details at left...
9.	Dopamine Agents (Dopaminergic Agents)IBA 01/01/2007 - "Dopaminergic agents are the best-studied agents and are considered first-line treatment of restless legs syndrome (RLS)" 09/01/2001 - "Dopaminergic agents are highly effective in treating restless legs syndrome, but side effects can be problematic" 12/10/2005 - "Restless Legs Syndrome (RLS) has become a well known disorder in the medical community in Switzerland within the last ten years, particularly since the official introduction of dopaminergic drugs as first line treatment" 11/01/2002 - "Several pieces of evidence suggest that a dopaminergic dysfunction might play a key role in the pathophysiology of restless legs syndrome (RLS), including the therapeutic effects of dopaminergic drugs and the results of several positron emission tomography and single photon emission computed tomography studies" 11/01/1990 - "The study showed that the relief of symptoms of restless legs syndrome by dopaminergic drugs does not wear off with the passage of time, that side effects are minimal even with long-term use, and that the dose needed to obtain relief may increase as well as decrease." Order ALL the reference details at left...
10.	Clonazepam (Rivotril)FDA LinkGeneric 02/13/1982 - "Clonazepam: effective treatment for restless legs syndrome in uraemia." 10/03/1981 - "Clonazepam: effective treatment for restless legs syndrome in uraemia." 08/01/1986 - "The treatment of the restless legs syndrome with clonazepam: a prospective controlled study." 09/01/1992 - "Fifteen patients with restless legs syndrome underwent whole-night polysomnographic recordings before and during clonazepam treatment" 09/01/1992 - "Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment." Order ALL the reference details at left...

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 03/01/2008 - "We present the first study on the influence of exercise training on restless legs syndrome (RLS) in patients on hemodialysis (HD)" 02/01/2007 - "METHODS: A cross-sectional multicentric study in which 166 consecutive hemodialysis patients were evaluated using a standard questionnaire based on diagnostic criteria elaborated by the International Restless Legs Syndrome Study Group was performed" 03/01/2003 - "Restless legs syndrome in hemodialysis patients in India: a case controlled study." 05/01/2007 - "BACKGROUND: Restless legs syndrome (RLS) is a common cause of sleep disturbance frequently experienced by hemodialysis patients" 02/01/2007 - "Restless legs syndrome prevalence in patients on chronic hemodialysis in central Serbia]" Order ALL the reference details at left...
2.	Deep Brain Stimulation 08/01/2006 - "We report on 6 advanced Parkinson's disease (PD) patients who underwent bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) surgery whose restless legs syndrome (RLS) improved postoperatively" 03/01/2006 - "VIM deep brain stimulation does not improve pre-existing restless legs syndrome in patients with essential tremor." 04/01/2005 - "Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia." 12/28/2004 - "The authors systematically studied the emergence of restless legs syndrome (RLS) after subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD)" 04/01/2005 - "We report on the case of a woman with generalized dystonia and restless legs syndrome whose restless legs resolved after bilateral internal globus pallidus deep brain stimulation, and recurred unilaterally after an infection required removal of one of the devices." Order ALL the reference details at left...
3.	Exercise (Aerobic Exercise) 03/01/2008 - "Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study." Order ALL the reference details at left...
4.	Walkers 01/01/1996 - "A questionnaire study of 138 patients with restless legs syndrome: the 'Night-Walkers' survey." Order ALL the reference details at left...
5.	Kidney Transplantation 05/01/2007 - "Evaluation of effect of renal transplantation in treatment of restless legs syndrome." 02/01/2005 - "Restless Legs Syndrome in patients after renal transplantation." 09/01/2002 - "Long-term course of restless legs syndrome in dialysis patients after kidney transplantation." 01/01/1986 - "Restless legs syndrome treated successfully by kidney transplantation--a case report." 12/01/2007 - "Restless legs syndrome, insomnia, and quality of life after renal transplantation." Order ALL the reference details at left...

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