|1.||Chronic Obstructive Pulmonary Disease (COPD)
|5.||Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
|1.||Dahan, Albert: 27 articles (04/2015 - 02/2003)|
|2.||Conti, Giorgio: 20 articles (02/2016 - 01/2002)|
|3.||Tobias, Joseph D: 18 articles (02/2014 - 06/2002)|
|4.||Philipp, Alois: 17 articles (09/2015 - 01/2009)|
|5.||Nava, Stefano: 17 articles (03/2015 - 05/2002)|
|6.||Baud, Frédéric J: 16 articles (08/2013 - 01/2002)|
|7.||Bartlett, Robert H: 15 articles (02/2016 - 05/2003)|
|8.||Schmid, Christof: 15 articles (09/2015 - 01/2009)|
|9.||Antonelli, Massimo: 15 articles (09/2013 - 01/2003)|
|10.||Azoulay, Elie: 14 articles (02/2016 - 05/2008)|
01/01/2015 - "There was a significantly greater number of patients with previously confirmed chronic respiratory failure using long-term oxygen theraphy in A group (p = 0.029). "
01/01/2008 - "The high-flow oxygen therapy system is effective in a large percentage of children with high oxygen requirements and/or moderate respiratory failure."
01/01/2008 - "To analyze the efficacy of a high-flow oxygen therapy system in children with moderate respiratory failure and/or high oxygen requirements. "
12/01/1990 - "These results suggest that PCV may be a beneficial ventilatory modality in the treatment of severe respiratory failure since it results in improvement in arterial oxygenation, tissue oxygen delivery and utilization without any concomitant adverse effects on other hemodynamic or ventilatory factors."
10/01/1986 - "Four patients with acute respiratory failure had a significant decrease in PaCO2, HCO3-, and BE and an increase in arterial oxygen pressure, indicating that in both of these patient groups alveolar ventilation had improved. "
|2.||Nitric Oxide (Nitrogen Monoxide)FDA Link
01/01/2007 - "Inhaled nitric oxide (iNO) has been proven to be effective in term infants with hypoxic respiratory failure. "
01/01/2006 - "Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. "
01/01/2001 - "Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. "
01/01/2001 - "Inhaled nitric oxide has been proven effective in term infants with hypoxic respiratory failure. "
01/01/2003 - "Initial studies examining the effect of inhaled nitric oxide in respiratory failure demonstrated transient improvement in oxygenation but did not examine mortality or other significant morbidity outcomes. "
|3.||Morphine (MS Contin)FDA LinkGeneric
12/01/1985 - "The results of this study are compatable with the hypothesis that the delayed onset of respiratory depression sometimes observed following epidural morphine in opioid naive patients results from significant amounts of morphine reaching the respiratory centre in the brain-stem as a consequence of passive CSF flow in a rostral direction from the lumbar region."
03/01/1993 - "When EA was administered together with morphine, peristalsis of the duodenum was much less inhibited (P < 0.05, vs morphine alone group), but no significant improvement of respiratory depression was noticed (P > 0.05), nor obvious change of arterial pressure in both groups. "
12/01/1996 - "However, NOS inhibitor treatment is more effective in suppressing morphine-induced ventilatory depression when given before, rather than after, morphine administration. "
03/01/2005 - "These changes were maintained at 30 min. Follow up treatment with oral morphine remained effective in reducing the symptom of breathlessness and no patient showed signs of respiratory depression. "
03/05/2013 - "The present study suggests that activation of cholinergic or serotonergic (5-HT1A) mechanisms may be a useful therapeutic approach for morphine-induced ventilatory depression without loss of its analgesic action."
|4.||Naloxone (Narcan)FDA LinkGeneric
01/01/2014 - "Protective effects have been observed with training individuals at high risk of overdose and prescribing them naloxone, an opioid antagonist that reverses the effects of the opioid-induced respiratory depression that causes death. "
12/01/1980 - "Respiratory depression was treated successfully with naloxone."
05/12/2014 - "Intranasal naloxone is as effective as IV naloxone in reversing both respiratory depression and depressive effects on the central nervous system caused by opioid overdose."
01/03/2005 - "IN naloxone is effective in treating opiate-induced respiratory depression, but is not as effective as IM naloxone. "
09/05/2014 - "While, a single injection of naloxone (150.0 μg/kg, i.m.) only achieved partial remission of respiratory depression. "
10/01/2011 - "In contrast, arteriovenous carbon dioxide removal (AVCO(2)R) is a novel strategy that has been shown to be highly effective in adults with acute respiratory failure. "
12/01/2015 - "The KD may significantly decrease carbon dioxide body stores, which may theoretically be beneficial for patients with increased carbon dioxide arterial partial pressure due to respiratory insufficiency or failure."
06/01/2006 - "The 6-month NNPPV treatment significantly decreased the partial pressure of carbon dioxide and improved daytime respiratory muscle function, thus contributing to exercise-capacity increase in patients with chronic respiratory failure."
04/01/2008 - "The aim of this study was to assess the usefulness of SenTec Digital Monitor System in measuring transcutaneous arterial carbon dioxide partial tension (PCO2) non-invasively for the management of chronic respiratory failure. "
04/01/2006 - "Addition of carbon dioxide to the hypoxic exposure eliminated the respiratory depression. "
02/01/1989 - "The results of this study indicate that both HFPPV and HFJV are effective in short-term maintenance of normal blood gases in respiratory failure without any discernable differences in their effects on cardiovascular function. "
06/01/1998 - "In conclusion, in the tested settings VPAP-S/T is as effective as BiPAP-S/T in maintaining ventilation and controlling blood gases during sleep in patients with stable respiratory insufficiency."
12/01/1984 - "Surfactant replacement restores blood gases to normal in adult experimental animals with severe respiratory insufficiency induced by repeated lung lavage, suggesting that this type of treatment might be effective in clinical adult RDS."
01/01/2000 - "Up to 24 h after the start of ventilatory support blood gases were improved to values characteristic for partial respiratory insufficiency. "
01/01/1968 - "[Study of the variations of arterial blood gases during a 24-hour period in chronic respiratory insufficiency]."
|7.||Fentanyl (Sublimaze)FDA LinkGeneric
09/01/2013 - "An explorative study on the effects of fentanyl on antinociception and respiratory depression was performed to construct fentanyl risk-benefit (utility) functions. "
09/01/2008 - "Many studies have been conducted to assess the effects of fentanyl on the autonomic nervous system (ANS) by heart rate variability (HRV) analysis, but disagreement on the results is still present due to confounding influences introduced by concomitant administration of other drugs or opioid-related transitory respiratory depression. "
05/01/2007 - "Judicious monitoring for opioid-induced respiratory depression is recommended for fentanyl ITS, although this adverse effect has not been observed in clinical trials. "
03/01/2004 - "The aim of this study was to evaluate the validity of the SCSB compared with the respiratory inductive plethysmograph (RIP) using a fentanyl-induced respiratory depression model. "
11/01/2015 - "However, such rapid increase in plasma concentration of fentanyl by ROO formulations may cause the risk of respiratory depression. "
|8.||Adrenal Cortex Hormones (Corticosteroids)IBA
05/01/1995 - "carinii-related respiratory failure, only adjunctive corticosteroids were associated with a significant improvement in survival to successful removal of the tracheal tube, from a historical rate of 11% to 91%."
09/01/2010 - "Of the seven patients who developed ILD, six were treated with corticosteroids, and the ILD improved in three of them, but the other three patients died of respiratory failure. "
11/01/2012 - "Over a one-year follow up, the patient's respiratory failure has progressed markedly despite treatment with corticosteroids. "
06/01/2011 - "Despite corticosteroids, 12 (80%) patients died, mostly of untractable respiratory failure (n = 9). "
01/01/2011 - "However, it can rapidly worsen and lead to respiratory failure that is refractory to corticosteroids. "
04/01/1997 - "Concerning respiratory failure after open heart surgery, however, we think that a respiratory function of a patient is improved if high-dose methylprednisolone pulse therapy is started in early stage."
06/13/2000 - "There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. "
01/01/2015 - "This case demonstrates the effects of high-dose methylprednisolone therapy in improving respiratory failure. "
01/01/2015 - "Respiratory failure progressed, and high-dose methylprednisolone therapy was administered; the respiratory failure regressed immediately after the onset of therapy. "
02/01/2003 - "Preoperative administration of methylprednisolone attenuates cytokine-induced respiratory failure after esophageal resection."
|10.||Midazolam (Versed)FDA LinkGeneric
01/01/2015 - "Patients administered midazolam trended towards higher rate of respiratory depression (OR = 1.27, 95% CI 1.00-1.60, P = 0.050). "
11/01/2009 - "The frequency of respiratory depression was higher in midazolam group. "
10/15/2005 - "Respiratory depression, assessed by the elevation in PaCO2, was more closely correlated with midazolam striatal dialysate rather than plasma kinetics. "
04/01/2004 - "Midazolam should be offered only to hemodynamically stable patients without preceding respiratory depression."
12/01/2002 - "Furthermore, midazolam potentially reduces respiratory depression and time to treatment."
|1.||Artificial Respiration (Mechanical Ventilation)
01/01/2014 - "Non-invasive mechanical ventilation provides early improvement in most of the patients with acute hypercapnic respiratory failure. "
01/01/2011 - "Non-invasive mechanical ventilation is considered highly effective for treating chronic respiratory failure. "
11/01/1994 - "The following conclusions are drawn from critical evaluation of the collected data: (1) Closed system positive pressure mechanical ventilation applied at mild to moderate levels of intensity is a safe and effective method for augmenting deficient blood gas exchange in most patients who are in acute respiratory failure. "
06/01/1997 - "Respiratory failure developed within 54 h and CO2 could not be eliminated, even by very invasive mechanical ventilation. "
06/01/2011 - "The aim was to study the efficacy of rescue High Frequency Oscillatory Ventilation (HFOV) in improving the oxygenation and ventilation in neonates with acute respiratory failure after failing Conventional Mechanical Ventilation (CMV). "
|2.||Positive-Pressure Respiration (PEEP)
10/01/2005 - "In particular, noninvasive positive pressure ventilation (NIPPV) is effective in resolving respiratory failure and has dramatically changed the management of these patients. "
01/01/2007 - "In randomized studies of heterogeneous patients with hypoxemic acute respiratory failure, noninvasive positive pressure ventilation (NPPV) was associated with a significant reduction in endotracheal intubation. "
02/01/2012 - "Noninvasive positive pressure ventilation is beneficial for patients with acute respiratory failure. "
03/01/2010 - "Noninvasive positive pressure ventilation (NPPV) is another treatment modality that may be beneficial in patients with severe asthmatic attack who are at an increased risk of developing respiratory failure. "
01/01/2003 - "In this case, recruitment maneuver and high PEEP relieved postoperative respiratory failure. "
|3.||Extracorporeal Membrane Oxygenation (ECMO)
07/01/1996 - "We then present our experience from the past 11 years in the most invasive, yet successful, therapy for acute respiratory failure-extracorporeal membrane oxygenation (ECMO). "
01/01/2006 - "While extracorporeal membrane oxygenation is proven to result in improved outcome when compared to conventional ventilation in neonates with severe respiratory failure, there is currently no good evidence from randomised controlled trials to compare these managements for important clinical outcomes in adults, although evidence from case series is promising. "
03/01/2012 - "Veno-venous ECMO for 2009 H1N1-associated respiratory failure gives good results with a very low mortality rate. "
01/01/2008 - "A policy of using ECMO in mature infants with severe but potentially reversible respiratory failure results in significantly improved survival without increased risk of severe disability. "
01/01/2002 - "A policy of using ECMO in mature infants with severe but potentially reversible respiratory failure would result in significantly improved survival without increased risk of severe disability amongst survivors. "
|4.||Mechanical Ventilators (Ventilator)
06/01/2011 - "One quarter of AAV patients develop AH, which when mild is associated with a good outcome, but mortality rises to 50% for cases with respiratory failure requiring ventilator support. "
08/01/1996 - "Administration of calf's lung surfactant appears to be safe and is associated with rapid improvement in oxygenation and moderation of ventilator support in children with acute hypoxemic respiratory failure. "
06/01/1981 - "Results indicate that regular efficient night-time support by body respirator provides a constant significant improvement in daytime gas exchange for periods averaging up to 2 years following the occurrence of moderately severe respiratory failure. "
07/01/1989 - "Home care of ventilator-dependent people is increasing in use due to improved management of respiratory failure and the development of effective portable ventilators. "
02/01/1991 - "The results of this initial trial suggest that the volumetric diffusive respirator is a safe and effective method of ventilation in neonates with respiratory failure and that the survival rate in such neonates might be enhanced if treatment is introduced earlier in the disease."
03/01/2009 - "The study was adequately powered to detect a decrease in potency of 5-24% for analgesia, 20-48% for respiratory depression, and 32% for sedative effects. "
01/01/2008 - "Recent scientific studies have shown no evidence of a ceiling dose of analgesia in man but only a ceiling effect for respiratory depression, increasing its safety profile. "
08/01/2003 - "These were included if ITM use was appropriate (bolus dose, postoperative analgesia) and the term "respiratory depression" was used, which left 96 studies remaining. "
08/01/2003 - "Medline (1966 - June Week 5 2001) and reference lists were searched for original studies involving bolus-dose ITM for postoperative analgesia, which used "respiratory depression" or similar terms. "
01/01/1989 - "A study with 360 patients was performed in order to investigate the suitability of opioid analgesia during ESWL with special regard to cardiovascular and respiratory depression and other side-effects. "