|4.||Lyme Disease (Disease, Lyme)
|1.||Schwan, Tom G: 12 articles (01/2012 - 02/2003)|
|2.||Barbour, Alan G: 11 articles (07/2015 - 02/2004)|
|3.||Raffel, Sandra J: 10 articles (01/2012 - 02/2003)|
|4.||Schrumpf, Merry E: 8 articles (04/2010 - 02/2003)|
|5.||Zückert, Wolfram R: 7 articles (12/2011 - 03/2004)|
|6.||Porcella, Stephen F: 7 articles (08/2009 - 02/2003)|
|7.||Bergström, Sven: 6 articles (01/2014 - 03/2008)|
|8.||Lopez, Job E: 6 articles (01/2013 - 12/2008)|
|9.||Londoño, Diana: 6 articles (01/2010 - 11/2005)|
|10.||Cadavid, Diego: 6 articles (01/2010 - 11/2005)|
|1.||Complement System Proteins (Complement)IBA
10/01/2014 - "The relapsing fever spirochete Borrelia miyamotoi resists complement-mediated killing by human serum."
01/01/2014 - "The relapsing fever spirochete Borrelia miyamotoi is cultivable in a modified Kelly-Pettenkofer medium, and is resistant to human complement."
05/01/2008 - "Bactericidal action of a complement-independent antibody against relapsing fever Borrelia resides in its variable region."
01/01/1948 - "A complement fixation test for the diagnosis of relapsing fever."
01/01/2013 - "valaisiana to inhibit bacteriolysis appears not to involve binding of the key host complement regulators of the alternative, classical, and lectin pathways as already known for serum-resistant Lyme disease or relapsing fever borreliae."
|2.||Tetracycline (Achromycin)FDA LinkGeneric
09/01/2003 - "The best treatment for relapsing fever is tetracycline or doxycycline. "
01/01/1995 - "A clinical trial was conducted in order to evaluate the efficacy of procaine penicillin and tetracycline, respectively, in the treatment of louse-borne relapsing fever. "
01/01/1995 - "Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial."
07/01/1992 - "Tetracycline versus penicillin in the treatment of louse-borne relapsing fever."
05/01/1983 - "Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin."
|3.||Immunoglobulin M (IgM)IBA
12/01/2006 - "While these results indicated that the production of IgM was delayed in MyD88(-/-) mice, they also point to a second, antibody-independent role for MyD88 signaling in host defense to relapsing fever Borrelia. "
12/01/2006 - "Relapsing fever Borrelia spp. undergo antigenic variation, achieve high levels in blood, and require rapid production of immunoglobulin M (IgM) for clearance. "
04/01/2003 - "Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis."
04/01/2003 - "The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes."
03/01/1985 - "Positive reactions in the IgM Dot-ELISA occurred in 2 of 30 control, 4 of 10 Lyme disease, 1 of 11 relapsing fever, and 1 of 8 yaws sera; 10 syphilis patient sera were nonreactive. "
|4.||Penicillins (Penicillin)FDA Link
01/01/1995 - "As mortality is linked to severe JHR, and most relapses are clinically mild and easily treated, these results speak in favour of using low-dose penicillin to initiate the treatment of relapsing fever."
08/01/1949 - "The effect of penicillin on the behaviour of spirochaetes in natural and inoculated relapsing fever."
09/01/1947 - "Comparative effectiveness of penicillins G, F, K, and X in experimental relapsing fever."
06/01/1947 - "Relapsing fever in Cullinan (Transvaal) with a short reference to penicillin therapy."
03/01/1947 - "Penicillin therapy in relapsing fever; report of four cases."
|5.||Interleukin-10 (Interleukin 10)IBA
08/01/2008 - "Our results indicate that at times of high pathogen load, as during peak bacteremia in relapsing fever borreliosis, IL-10 protects innate immune cells from apoptosis via inhibition of TNF resulting in improved pathogen control."
01/01/2007 - "Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae."
10/01/2008 - "In previous studies of the pathogenesis of spirochetal brain infection, mice inoculated with Borrelia turicatae, an agent of tick-borne relapsing fever in North America, developed mild meningitis and parenchymal activation/infiltration by interleukin 10 (IL-10)-producing microglia/macrophages. "
01/01/2007 - "The results suggest IL-10 plays a protective role as a down-regulator of inflammation and pathogen load during infection with relapsing fever spirochetes."
04/16/1983 - "Meptazinol is the first effective treatment for the J-HR of louse-borne relapsing fever. "
04/16/1983 - "Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever."
04/16/1983 - "Naloxone, an opioid antagonist, and meptazinol, an opioid antagonist with agonist properties, were tested in a double-blind placebo-controlled trial in 24 Ethiopian patients with louse-borne relapsing fever. "
05/21/1983 - "Meptazinol, a partial opioid agonist, diminishes the Jarisch-Herxheimer reaction in relapsing fever whereas naloxone, a pure opioid antagonist, is virtually inert. "
10/01/2014 - "Additionally, we found antibodies against Borrelia burgdorferi sensu lato (SL) spp. in 21% of voles, against Anaplasma phagocytophilum in 2.6%, Rickettsia spp. in 13%, relapsing fever Borrelia (3.9%), and T. "
01/01/2012 - "Small mammals were captured, thin blood smears were examined microscopically for spirochetes, and serum samples were tested for antibodies to relapsing fever spirochetes. "
10/01/2000 - "We conclude that assessment of anti-GlpQ antibodies will allow serological confirmation of louse-borne relapsing fever and determination of disease prevalence."
05/01/1999 - "The diagnosis was confirmed by the standard Giemsa hemoscopy and by the identification of significant titers of antibodies to Borrelia spp. of tick-borne relapsing fevers by specific immunofluorescence and Western blot tests. "
12/01/1998 - "We found antibodies to different forms of variable major protein in two patients with louse-borne relapsing fever. "
|8.||Doxycycline (Vibramycin)FDA LinkGeneric
04/01/2008 - "A rare case of relapsing fever which was successfully treated with doxycycline is discussed."
10/12/2006 - "Doxycycline for the prevention of tick-borne relapsing fever."
07/13/2006 - "Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever."
02/01/1993 - "Late relapse of tick-borne relapsing fever following treatment with doxycycline."
08/01/1975 - "Single-dose doxycycline treatment of tick-borne relapsing fever."
|9.||Chlortetracycline (Aureomycin)FDA Link
06/01/1956 - "[New evaluation of the treatment of Spanish relapsing fever with aureomycin]."
06/01/1954 - "[Aureomycin in relapsing fever in Spain]."
03/01/1954 - "[Treatment of relapsing fever in Spain by aureomycin]."
03/01/1953 - "[Relapsing fever and aureomycin]."
10/01/1951 - "The treatment of tick-borne relapsing fever in East Africa with special reference to aureomycin."
|10.||Oxytetracycline (Terramycin)FDA Link
06/01/1954 - "[Relapsing fever in Spain and its treatment with terramycin]."
06/15/1953 - "[Terramycin in the treatment of relapsing fever]."
11/01/1955 - "The prevention and treatment of tick-borne relapsing fever with special reference to aureomycin and terramycin."
01/01/1957 - " compounds and penicillin have been shown not to be very effective for the treatment of relapsing fever, but good results have been obtained with Aureomycin and Terramycin."
|1.||Blood Transfusion (Blood Transfusions)
|2.||Drug Therapy (Chemotherapy)
11/01/1953 - "Chemotherapy of experimental relapsing fever in mice with antibiotics and synthetic compounds."
02/01/1995 - "The serum concentrations of tumour necrosis factor (TNF), interleukin-6 (IL-6) and C-reactive protein (CRP) were studied in 25 patients with louse-borne relapsing fever, to evaluate their association with the level of bacteraemia, anti-borrelia chemotherapy and the presence of a Jarish-Herxheimer reaction (JHR). "