Rectal Fistula (Anal Fistula)

06/01/2008 - "This study was designed to evaluate the efficacy of the Surgisis (Anal Fistula Plug) in multiple patients at our institution and present early clinical results along with notable clinical observations from our experience. "
01/01/2021 - "The efficacy of the Biodesign Surgisis anal fistula plug in healing anal fistulae is uncertain. "
05/01/2010 - "The purpose of this study was to analyse preliminary experience and outcomes with the Cook Surgisis AFP anal fistula plug (Cook Medical, Bloomington, IN, USA) with respect to the treatment of complex anal fistulae in a specialist colorectal unit. "
01/01/2021 - "The Biodesign Surgisis anal fistula plug is associated with similar FIQoL and healing rates to surgeon's preference at 12 months. "
01/01/2019 - "The Surgisis anal fistula plug is associated with similar FIQoL score to surgeon's preference at 12-month follow-up. "

02/14/2010 - "We present a case of a HIV-positive patient with a complex extrasphincteric anal fistula who was treated successfully with fibrin glue application. "
06/01/2019 - "Treatment of complex cryptoglandular anal fistula with autologous PRP is as effective as fibrin glue with less cost and no adverse effect on continence."
05/01/2010 - "The study aimed to evaluate the efficacy of fibrin glue in the treatment of complex anal fistula. "
09/01/2003 - "Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial."
01/01/2021 - "The most common study design was retrospective cohort (17/33), and the most frequently reported interventions were anal fistula plug (n = 8) and fibrin glue (n = 6). "

03/01/2017 - "Permacol™ paste injection was safe and effective in some patients with complex anal fistula without compromising continence."
01/01/2023 - "We found that Zibai ointment effectively promoted wound healing in patients following anal fistula surgery, possibly by regulating Bcl-2 and Bax apoptosis-related factors."
01/01/2023 - "Investigating the role of Zibai ointment on apoptosis-related factors Bcl-2 and Bax in wound healing after anal fistula surgery."
02/01/2019 - "A prospective study was conducted on patients with anal fistula, treated with Permacol™ paste. "
01/01/2022 - "To explore the efficacy of Chinese herbal fumigation and sitz-bath combined with red ointment in the treatment of postoperative wound healing and pain control in anal fistula patients. "

08/01/2014 - "Results of collagen plug occlusion of anal fistula: a multicentre study of 126 patients."
01/01/2011 - "Management of idiopathic anal fistula using cross-linked collagen: a prospective phase 1 study."
02/01/2020 - "Non cross-linked equine collagen (Salvecoll-E gel) for treatment of complex ano-rectal fistula."
08/01/2017 - "Patients with an anal fistula were evaluated for eligibility in three centres, and randomized to either mucosal advancement flap surgery or collagen plug, with clinical follow-up at 3 and 12 months. "
08/01/2017 - "The role of a collagen plug for treating anal fistula is not well established. "

11/08/2022 - "Up till now, it is not common practice to routinely administer prophylactic antibiotics to prevent anal fistula development. "
01/01/2019 - "The aim of the present study was to perform a systematic review and meta-analysis of the current literature to determine the role of antibiotics in prevention of anal fistula following incision and drainage of anorectal abscesses. "
02/01/2009 - "Gender, smoking history, perioperative antibiotic treatment, and HIV status were not risk factors for chronic anal fistula or recurrent anal sepsis."
04/01/2023 - "Postoperatively, the patient developed a pelvic abscess due to wound infection from the anal fistula, which required drainage and antibiotic therapy. "
02/25/2019 - "During incision of the abscess an anal fistula was suspected, and six weeks after primary surgery and treatment with relevant antibiotics, transanal ultrasonography showed perianal scarring and no signs of anocutaneous fistula."

09/01/2016 - "The aim of the present study was to compare the efficacy between seton drainage combined with anti-TNF-α and seton drainage combined with immunosuppressant postoperatively on the treatment of CD-related anal fistula. "
08/01/2021 - "In total, consensus was reached on 14 statements on the risk factors for AFR in three domains: patient-related risk factors included comorbid colitis, inflammatory bowel disease and use of immunosuppressants; fistula-related factors included transsphincteric fistula, number of fistula, horseshoe extension, undetected internal opening, location of anal fistula, recurrent fistula, suprasphincteric fistula, and height of the internal opening; and surgery-related factors included type of surgery, previous fistula surgery and surgeon. "
09/01/2016 - "A total of 65 patients with CD-related anal fistula who had received seton drainage combined with postoperative medication were divided into an antibiotics only group, anti-TNF-α group and immunosuppressant group; all patients were treated with antibiotics. "
09/01/2016 - "Similar outcomes for anti-tumor necrosis factor-α antibody and immunosuppressant following seton drainage in patients with Crohn's disease-related anal fistula."
04/01/2016 - "The current literature is limited by a number of factors, including small study cohorts, grouping of fistulae in Crohn's disease with other types of anal fistula, short and highly variable follow-up times and multiple confounding factors such as number of fistula tracts, use of preoperative steroids or immunosuppressants, previous use of setons and variation in surgical technique."

10/01/2003 - "The aim of this study was to evaluate the accuracy of hydrogen peroxide-enhanced ultrasound in localizing the internal opening of the anal fistula. "
12/01/2007 - "Forty-three patients with anal fistula were assessed by TPUS with and without the use of hydrogen-peroxide injection (E-TPUS) in an attempt to identify the internal opening. "
01/01/2004 - "A total of 80 patients with anal fistula were studied prospectively by physical examination and endoanal ultrasound enhanced with hydrogen peroxide. "
10/01/2003 - "A total of 57 patients (47 men) of mean age of 45.7 (range, 21-77) years underwent hydrogen peroxide-enhanced ultrasound with a diagnosis of anal fistula; 36 patients underwent surgery. "
10/01/2003 - "A retrospective review of all patients with anal fistula who underwent hydrogen peroxide-enhanced ultrasound was performed. "

11/01/2021 - "In recent years, a number of clinical retrospective studies have proved the feasibility of placing various kinds of pedicled tissue flap between the rectum and urethra, and its application has provided a new solution for the treatment of urethral rectal fistula, and achieved satisfactory results. "
11/01/2009 - "[Temporary total fecal diversion--ultimate solution for complex recurrent anal fistula]."
07/01/2014 - "This study demonstrates that the application of silver nitrate solution often produces a favorable outcome in the treatment of anal fistula. "
07/25/2018 - "The brief steps were as follows: insertion of the anal fistula scope through external opening into the fistula; continuous injection of glycine-mannitol solution to expand and clean the foul fistula; electrocoagulation of all lesions; clearance of burnt tissues from the lumen with endoscopic brush and forceps; injection of medical fibrin glue through the inner opening; closing the inner opening by suture. "

07/01/2008 - "In this multicenter, randomized, double-blind, placebo-controlled trial, patients with CD and at least one active anal fistula under treatment were assigned to receive either AST-120 or placebo for 8 wk. Improvement was defined as a reduction of 50% or more from baseline in the number of draining fistulas observed at both 4 and 8 wk. Remission was defined by closure of all draining fistulas at both 4 and 8 wk. The Perianal Disease Activity Index (PDAI) and Crohn's Disease Activity Index (CDAI) were also assessed. "

01/01/2022 - "Autologous Bioactive Compound Concentrated Growth Factor Ameliorates Fistula Healing of Anal Fistula in a Pig Model and Promotes Proliferation and Migration of Human Skin Fibroblasts via Regulating the MEK/ERK Pathway."
10/01/2023 - "At present, modern medical treatment of wounds after anal fistula surgery mostly focuses on physical therapy intervention, new wound dressing and packing, and external application of growth factors. "

02/01/2016 - "High Ligation of the Anal Fistula Tract by Lateral Approach."
04/01/2014 - "To evaluate the effectiveness of the interesphincteric ligation technique of the fistulous tract in the treatment of anal fistula. "
09/01/2012 - "We conducted a preliminary investigation of a modified technique for complicated trans-sphincteric anal fistula by high ligation of the track using a lateral approach. "
11/01/2011 - "The anatomy of failures following the ligation of intersphincteric tract technique for anal fistula: a review of 93 patients over 4 years."
04/01/1996 - "The anal fistula was treated by decision in 14 patients or by an elastic ligature (multiple seton) in 14 patients. "

11/01/2014 - "This case suggested that preoperative chemoradiotherapy could be effective for locally advanced carcinoma associated with anal fistula. "
11/01/2013 - "[A case of carcinoma associated with anal fistula effectively treated with preoperative chemoradiotherapy]."
11/01/2012 - "This case suggested that surgical treatment combined with preoperative chemoradiotherapy may be effective for locally advanced carcinoma associated with anal fistula. "
08/01/2011 - "The histological effect of chemoradiotherapy was judged as grade 2. This case suggested that surgical treatment combined with preoperative chemoradiotherapy may be effective for locally advanced carcinoma associated with anal fistula, in which preservation of adjacent organs is considered to be difficult."
08/01/2011 - "[A case of carcinoma associated with anal fistula resected after preoperative chemoradiotherapy]."

06/01/2023 - "Based on this background, results of stem cell therapy for Crohn's anal fistula have shown promising results and are a sphincter-preserving technique. "
01/01/2021 - "The aim of this study was to report long-term outcomes in patients who received FiLaC® therapy for transsphincteric and intersphincteric anal fistula between January 2011 and December 2017. "
01/01/2018 - "This study highlights two key challenges in the treatment pathway: (i) delays in diagnosis of underlying CD in patients with anal fistula and (ii) the pathway to anti-TNF therapy is long, suggesting issues with service design and delivery. "
12/01/2009 - "The trial shows that the tunnel thread-drawing therapy for simple anal fistula can shorten the course of recovery and improve the patients' quality of life. "
12/01/2009 - "The trial showed that the tunnel thread-drawing therapy was significantly more effective than classical method for improving the anal sphincter function and patient satisfaction with treatment in the patients with high anal fistula. "

03/01/2016 - "Comment on: Easy clip to treat anal fistula tracts: a word of caution by M. "
05/01/2015 - "Treatment of anal fistula by placing a clip on the internal opening is disappointing and deleterious for some patients. "
05/01/2015 - "Easy clip to treat anal fistula tracts: a word of caution."
09/01/2013 - "The OTSC® Proctology clip system for anal fistula closure: first prospective clinical data."
09/01/2012 - "The anal fistula claw: the OTSC clip for anal fistula closure."

05/01/2015 - ""Core out" or "curettage" in rectal advancement flap for cryptoglandular anal fistula."
03/01/2022 - "Following an accurate curettage of the anal fistula, the cryopreserved amniotic membrane was thawed and then washed in the operating room; one side of the membrane was transfixed with a resorbable suture thus creating an implantable fusiform patch. "
03/01/2005 - "In an experimental porcine model of anal fistula, granulation tissue was still present, albeit diminished, following track curettage combined with seton or sealant therapy, and was minimal in the sealant group, confirming some benefit from this procedure. "
02/01/2016 - "According to MRI and histopathological results, fistula tract curettage and fistula orifice closure improved transsphincteric anal fistula healing. "
01/01/2019 - "This study compares three procedures in which the anal fistula was sealed using platelet-rich fibrin: for the patients in group A, the plug was surgically inserted, under anaesthesia, and traditional methods were used to curette the fistula tract and close the internal orifice; for those in group B, the plug was surgically inserted, under anaesthesia, after curettage of the fistula tract using a graduated set of cylindrical curettes, and the internal orifice was closed as before; and for those in group C, the plug was inserted during outpatient consultation, without anaesthesia, without curettage and without closure of the internal orifice. "