|1.||Rapoport, Basil: 43 articles (06/2015 - 07/2002)|
|2.||McLachlan, Sandra M: 42 articles (06/2015 - 07/2002)|
|3.||Chen, Chun-Rong: 28 articles (06/2015 - 07/2002)|
|4.||Nagayama, Yuji: 25 articles (10/2015 - 03/2002)|
|5.||Davies, Terry F: 20 articles (01/2015 - 12/2002)|
|6.||Paschke, R: 19 articles (12/2012 - 09/2000)|
|7.||Latif, Rauf: 15 articles (01/2015 - 12/2002)|
|8.||Aliesky, Holly A: 13 articles (06/2015 - 05/2006)|
|9.||Paschke, Ralf: 13 articles (10/2014 - 03/2002)|
|10.||Rapoport, B: 13 articles (10/2012 - 01/2000)|
|1.||Graves Disease (Basedow Disease)
02/01/2004 - "The aim of this study was to evaluate the ability of the more sensitive second-generation TSH receptor (TRAb) assay to predict recurrent Graves' disease (GD) vs. remission depending on TRAb levels. "
01/01/2008 - "The majority of patients with Graves' disease gradually enter remission of TSH-receptor autoimmunity during medical or after surgical therapy, with no difference between the types of therapy. "
09/01/1989 - "Increased activated T-lymphocytes and normal thyrotropin receptor antibody levels in Graves' disease in long-term remission."
01/01/1989 - "It is hoped that understanding of Graves' disease will benefit from improvement in our knowledge of the TSH receptor structure and functions."
10/01/1985 - "Improved receptor and bioassays have been used to compare TSH receptor binding and thyroid stimulating activities in unextracted sera from 110 patients with Graves' disease. "
05/01/2014 - "The main difference in the clinical outcome of hyperthyroidism was that no patients with a TSH receptor mutation achieved euthyroidism throughout the follow-up, while 23.5% of patients without any mutation entered remission. "
02/01/2006 - "Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice."
01/01/2006 - "Our previous studies using HEK-293 cells expressing the extracellular domain of the TSH receptor (TSHR) showed that Stat4-/- mice, which lack Th1 cells, are susceptible, whereas Stat6-/- mice, which lack Th2 cells, are resistant to the induction of Graves' hyperthyroidism. "
10/01/2015 - "All patients were further classified into three subgroups: a GD-active group (hyperthyroidism and TRAb (thyroid stimulating hormone receptor antibody) >7.5 U/L) (N=15), a GD-inactive group (euthyreosis and TRAb<1 U/L) (N=8), and other GD patients (euthyreosis and TRAb>1 U/L) (N=14). "
10/01/2015 - "The purpose of this article is to summarize the recent advances on experimental Graves' hyperthyroidism and orbitopathy as studied in two widely used mouse models, which involve repetitive genetic vaccinations using either adenovirus or in-vivo electroporation of the eukaryotic expression plasmid expressing the thyrotropin receptor (TSHR) as a vector. "
02/01/2009 - "Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia."
02/01/2007 - "In this view, the study of association between subclinical hypothyroidism and possible molecular effectors, such as polymorphisms in the TSH receptor (TSHR) gene, could be interesting. "
05/01/2015 - "Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2 gene."
01/01/2013 - "Patients with the syndrome of TSH unresponsiveness may have compensated or overt hypothyroidism with a wide spectrum of clinical and morphological alterations depending on the degree of impairment of TSH-receptor (TSH-R) function. "
01/01/2013 - "Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers."
05/01/2008 - "Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review."
09/01/2004 - "To ascertain the prevalence of germline mutations in the TSH receptor gene as a cause of juvenile thyrotoxicosis (JT) in non-autoimmune patients. "
09/01/2004 - "Prevalence of germline mutations in the TSH receptor gene as a cause of juvenile thyrotoxicosis."
10/01/1999 - "A novel thyrotropin receptor mutation in an infant with severe thyrotoxicosis."
08/01/1999 - "Thyrotoxicosis develops differently in these two disorders: GD stimulates TSH receptors through antibody binding, while ST destroys follicles, probably through an autoimmune mechanism. "
|5.||Thyroid Diseases (Thyroid Disease)
01/01/2014 - "Because the TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment. "
05/01/2005 - "Our previous studies using microsatellite markers near or in the TSH receptor (TSHR) gene revealed significant association between autoimmune thyroid disease (AITD) in Japanese patients and TSHR microsatellite alleles. "
01/01/2000 - "The aim of this study was the evaluation of the diagnostic and clinical impact of a new RRA (DYNOtest TRAKhuman) which uses the human recombinant TSH-Receptor in the diagnosis of autoimmune thyroid disease. "
12/01/2013 - "Targeting thyroid diseases with TSH receptor analogs."
12/01/2012 - "The thyroid-stimulating hormone receptor (TSHR) gene is a convincing candidate gene in the pathogenesis of certain thyroid diseases including MNG. "
|4.||Thyrotropin (Thyroid-Stimulating Hormone)
|8.||Iodide Peroxidase (Deiodinase)
|9.||DNA (Deoxyribonucleic Acid)
|2.||Drug Therapy (Chemotherapy)