Muscarinic Receptors (Muscarinic Acetylcholine Receptor)

One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.
Also Known As:
Muscarinic Acetylcholine Receptor; Muscarinic Receptor; Acetylcholine Receptor, Muscarinic; Muscarinic Acetylcholine Receptors; Receptors, Muscarinic; Acetylcholine Receptors, Muscarinic; Receptor, Muscarinic; Receptor, Muscarinic Acetylcholine; Receptors, Muscarinic Acetylcholine
Networked: 1839 relevant articles (59 outcomes, 211 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Wess, Jürgen: 19 articles (01/2015 - 04/2003)
2. Yamada, Shizuo: 18 articles (01/2014 - 11/2004)
3. Raufman, Jean-Pierre: 15 articles (11/2013 - 10/2002)
4. Dean, Brian: 13 articles (12/2015 - 04/2004)
5. Conn, P Jeffrey: 13 articles (08/2015 - 01/2008)
6. Cheng, Kunrong: 13 articles (11/2013 - 10/2002)
7. Lindsley, Craig W: 12 articles (08/2015 - 10/2008)
8. Scarr, Elizabeth: 11 articles (12/2015 - 02/2006)
9. Michel, Martin C: 11 articles (06/2014 - 09/2002)
10. Dean, B: 10 articles (01/2015 - 09/2000)

Related Diseases

1. Overactive Urinary Bladder (Overactive Bladder)
2. Schizophrenia (Dementia Praecox)
09/01/2014 - "We previously identified a group of subjects with schizophrenia who, on average, have a 75% decrease in cholinergic receptor, muscarinic 1 (CHRM1) in Brodmann's area (BA) 9. To extend this finding, we determined i) if the decrease in CHRM1 was present in another functionally related CNS region (BA6), ii) whether the marked decrease in CHRM1 was accompanied by changes in levels of other CHRMs and iii) potential factors responsible for the decreased CHRM1 expression. "
01/01/2012 - "Recent advances in developing compounds that are selective to muscarinic receptor subtypes or activate allosteric receptor sites offer tremendous promise for therapeutic targeting of specific muscarinic receptor subtypes in schizophrenia."
01/01/2012 - "This theory has been revitalized with a number of recent and provocative findings including postmortem reports in schizophrenia patients showing decreased numbers of muscarinic M(1) and M(4) receptors in brain regions associated with schizophrenia as well as decreased muscarinic receptors in an in vivo imaging study. "
01/01/2009 - "These trials and studies investigating the role of both nicotinic and muscarinic receptors in the pathology of the disorder, published during the last 5 years, are reviewed to ascertain whether there is a role for the cholinergic system in the treatment of schizophrenia."
09/15/2005 - "Recent studies have indicated that muscarinic receptors are involved in the pathophysiology in schizophrenia, particularly in cognitive deficits. "
3. Alzheimer Disease (Alzheimer's Disease)
4. Ganglion Cysts (Ganglion)
5. Bradycardia

Related Drugs and Biologics

1. Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
2. Acetylcholine (Acetylcholine Chloride)
3. Atropine (Hyoscyamine)
4. Scopolamine (Hyoscine)
5. Carbachol (Carbastat)
6. Muscarinic Antagonists
7. tiotropium (Spiriva)
8. GTP-Binding Proteins (G-Protein)
9. Pirenzepine
10. Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Injections
3. Intravenous Injections
4. Subcutaneous Injections
5. Denervation