Histamine H2 Receptors

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

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Networked: 155 relevant articles (10 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hellstrand, Kristoffer: 2 articles (01/2019 - 12/2012)
2.	Martner, Anna: 2 articles (01/2019 - 12/2012)
3.	Chen, Zhong: 2 articles (05/2015 - 10/2014)
4.	Ohtsu, Hiroshi: 2 articles (05/2015 - 10/2002)
5.	Adachi, Naoto: 2 articles (03/2007 - 03/2005)
6.	Arai, Tatsuru: 2 articles (03/2007 - 03/2005)
7.	Liu, Keyue: 2 articles (03/2007 - 03/2005)
8.	Asakura, Masanori: 2 articles (10/2006 - 05/2006)
9.	Asanuma, Hiroshi: 2 articles (10/2006 - 05/2006)
10.	Kim, Jiyoong: 2 articles (10/2006 - 05/2006)

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 01/01/1977 - "These results support the concept that the tissue accumulation of eosinophils following anaphylaxis depends on a complex interaction of factors, which in part may be mediated by H2 receptors on the target cells. " 09/01/1989 - "Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures." 10/01/1990 - "The pathophysiologic effects of histamine in anaphylaxis have been shown to be mediated through H1 and H2 receptors, individually and in combination. " 01/01/1996 - "It shows clear selectivity for histamine H1 as opposed to H2 receptors, has moderate activity against other potential mediators of allergic phenomena such as leukotriene C4 and platelet-activating factor, and is clearly effective against anaphylactic reactions resulting from exposure of suitably sensitised tissues or animals to antigen. "
2.	Heart Failure 10/03/2006 - "The goal of this work was to determine whether the blockade of histamine H2 receptors is beneficial for the pathophysiology of chronic heart failure (CHF). " 10/03/2006 - "Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies." 02/28/1986 - "Inasmuch as stimulation of both of these receptors results in a positive inotropic effect, further study should be given to the potential therapeutic utility of selective stimulation of myocardial alpha 1-adrenergic receptors and histamine H2 receptors in congestive heart failure. " 01/01/2016 - "Histamine H2 Receptors and Heart Failure: A Complex Cross-Talk." 02/28/1986 - "Although beta receptors are down-regulated in congestive heart failure, myocardial alpha 1-adrenergic receptors and histamine H2 receptors do not appear to be subject to this same regulatory process. "
3.	Hemorrhage 01/01/1984 - "Thirty-seven patients were treated with H2 receptors antagonists and the bleeding was controlled in 76.3% of cases in an average time of 21h. " 09/01/1998 - "Despite H2 receptors antagonist therapy, surgery has been required to control the repeated bleeding episodes." 07/01/1996 - "In our study we found no difference between omeprazole and histamine H2 receptors antagonists in controlling and recurrence of upper gastrointestinal bleeding." 07/01/1996 - "To compare the efficacy of omeprazole, a proton pump inhibitor, with Histamine H2 receptors antagonists in the control and recurrence of non-variceal upper gastrointestinal bleeding. "
4.	Asthma (Bronchial Asthma) 06/01/1987 - "[Identification of H1 and H2 receptors in the lung tissue of the guinea pig and their changes in experimental allergic asthma]." 01/01/2015 - "Histamine has long been suspected to play a role in the pathogenesis of asthma, but antihistamines that target the H1 and H2 receptors have not been shown to be effective for this condition. " 08/01/1991 - "We conclude that: 1. BHR to histamine in allergic asthma is related to a functional depression of H2 receptors in airways; 2. terfenadine is useful in the prevention and treatment of asthma."
5.	Bronchial Spasm 05/01/1979 - "Role of H1 and H2 receptors in histamine induced bronchospasm." 01/01/1994 - "The symptoms of hyperhistaminemia, mediated via H2 receptors, were prevented by the administration of an H2-blocker, famotidine, but wheezing due to bronchospasms, mediated via H1 receptors, developed and was improved by administration of chlorpheniramine. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Cimetidine (Biomet)
3.	Famotidine (Pepcid)
4.	Omeprazole (Prilosec)
5.	Histamine H1 Receptors (Histamine H1 Receptor)
6.	Histamine Antagonists (Antihistamines)
7.	Proton Pump Inhibitors
8.	Chlorpheniramine (Chlorphenamine)
9.	Leukotriene C4
10.	Platelet Activating Factor

Related Therapies and Procedures

1.	Therapeutics
2.	Induced Hypothermia
3.	Decompression
4.	Aftercare (After-Treatment)