Histamine Receptors (Histamine Receptor)

Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.

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Networked: 639 relevant articles (21 outcomes, 68 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohtsu, Hiroshi: 9 articles (11/2020 - 01/2006)
2.	Sasaguri, Yasuyuki: 9 articles (12/2018 - 02/2005)
3.	Wang, Ke-Yong: 8 articles (12/2018 - 02/2005)
4.	Tanimoto, Akihide: 8 articles (12/2016 - 02/2005)
5.	Watanabe, Takeshi: 8 articles (09/2013 - 07/2002)
6.	Neumann, Detlef: 6 articles (04/2020 - 01/2014)
7.	Francis, Heather: 6 articles (01/2018 - 10/2009)
8.	Yamada, Sohsuke: 6 articles (12/2016 - 08/2010)
9.	Seifert, Roland: 5 articles (04/2020 - 01/2014)
10.	Meng, Fanyin: 5 articles (01/2018 - 10/2009)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2021 - "Histamine receptors play important roles in various pathophysiological conditions and are effective targets for anti-allergy treatment, however the mechanism of receptor activation remain elusive. " 05/17/2012 - "Blockage of histamine receptor subtypes could prevent the excess mucus production associated with ocular allergy." 11/01/2005 - "Histamine receptors play an important role in the pathogenesis of nasal allergy. " 01/01/1993 - "Influence of histamine receptor antagonists on the dynamics of the cutaneous hypersensitivity reaction in patients infected with schistosoma haematobium." 08/01/1983 - "However, the participation of histamine receptors on dermal mast cells in the immediate skin allergic reaction is still left inconclusive."
2.	Pruritus (Itching) 01/01/2009 - "The best quality study for the pharmacological treatment of post-burn pruritus was selective histamine receptor antagonists. " 07/01/2020 - "However, since in many diseases with pruritus and prurigo the histamine receptor does not play a decisive role in the pathogenesis of pruritus, they show limited efficacy. " 09/01/2004 - "It inhibits mast cell degranulation and antagonises histamine receptors to manage the itching, redness, chemosis, tearing and lid swelling of the ocular allergic reaction, and its mast cell stabilising ability has been demonstrated both in vitro (using human conjunctival mast cells) and in vivo (human clinical experience). " 03/01/2021 - "Histamine acts by binding to four histamine receptors (H1 to H4), of which the H1 is known to participate in dilate blood vessels, bronchoconstriction, and pruritus. " 11/01/2019 - "Considering this information, it is suspected that the abrupt discontinuation of mirtazapine in the following patient case resulted in pruritus due to the reversal of antagonism at histamine receptors."
3.	Ulcer 01/01/2004 - "The effects of several histamine receptor antagonists on this ulcer model also were evaluated. " 09/01/1983 - "Inhibitory effects of histamine receptor antagonist on stress ulcer." 10/01/1989 - "The marked reduction in elective ulcer operations observed in our institution may be due to several factors, including better nonoperative therapy (eg, histamine receptor antagonists), physician preference for nonoperative treatment of chronic ulcers, or a reduced incidence of chronic ulcer within our population. " 05/01/1992 - "Bleeding asymptomatic ulcers are frequent and respond to H2 histamine receptor antagonists." 09/01/1983 - "Experimental studies on developmental mechanism of histamine induced ulcers and ulcer inhibitory effects of histamine receptor antagonists."
4.	COVID-19 10/19/2021 - "Instead, the use of histamine receptor 2 antagonists (H2RAs) seems to be associated with a better outcome in patients with COVID-19, in terms of symptoms, risk of intubation and death. " 01/01/2020 - "Further clinical studies in COVID-19 are warranted of the repurposed off-label combination of two historically-safe histamine receptor blockers." 01/01/2021 - "Histamine receptors and COVID-19." 01/01/2021 - "We propose that the principal mechanism of action of famotidine for relieving COVID-19 symptoms involves on-target histamine receptor H2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. " 08/31/2020 - "We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release."
5.	Pain (Aches) 01/01/2021 - "This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents. " 11/15/2016 - "Histamine receptors are involved in supraspinal modulation of pain. " 11/16/2001 - "In neuropathies irritable nociceptors may express histamine receptors or induce central sensitization to histaminergic stimuli so that itch converts into pain." 04/01/1986 - "The most recent trends in the classification of histamine receptors and how these receptors may interact with pain modulation are also considered." 12/01/2012 - "Histamine receptor H2 (Hrh2) has been shown to be effective for reducing pain and decreasing calcification in patients with calcifying tendinitis, which suggested that H2 blockers were effective for the treatment of tendon ossification or calcification. "

Related Drugs and Biologics

1.	Proton Pump Inhibitors
2.	Histamine Antagonists (Antihistamines)
3.	Antidepressive Agents (Antidepressants)
4.	Histamine (Histamine Dihydrochloride)
5.	Antacids
6.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)
7.	Histamine Agonists
8.	1-phenyl-3,3-dimethyltriazene (PDT)
9.	Acids
10.	Mast Cell Stabilizers

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Oral Administration
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)