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Epidermal Growth Factor Receptor (EGF Receptor)

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Also Known As:
EGF Receptor; Receptor, Epidermal Growth Factor; Epidermal Growth Factor Receptor Kinase; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; Proto-Oncogene Protein, erbB-1; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha; Receptors, Epidermal Growth Factor Urogastrone; c erbB 1 Protein; erbB 1 Proto Oncogene Protein; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Receptor, EGF; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein
Networked: 16151 relevant articles (732 outcomes, 1830 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Jänne, Pasi A: 72 articles (12/2015 - 09/2002)
2. Mitsudomi, Tetsuya: 69 articles (01/2016 - 12/2004)
3. Ciardiello, Fortunato: 66 articles (10/2015 - 06/2002)
4. Zhang, Li: 58 articles (12/2015 - 11/2002)
5. Pao, William: 56 articles (05/2015 - 02/2004)
6. Hirsch, Fred R: 55 articles (12/2015 - 02/2002)
7. Kris, Mark G: 47 articles (12/2015 - 06/2003)
8. Kiura, Katsuyuki: 47 articles (03/2015 - 01/2004)
9. Baselga, José: 46 articles (04/2015 - 01/2002)
10. Yatabe, Yasushi: 46 articles (03/2015 - 05/2004)

Related Diseases

1. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Lung Neoplasms (Lung Cancer)

Related Drugs and Biologics

1. Protein-Tyrosine Kinases (Tyrosine Kinase)
2. gefitinib (Iressa)
3. trastuzumab (Herceptin)
4. erlotinib (CP 358,774)
5. cetuximab (Erbitux)
6. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7. Monoclonal Antibodies
8. Epidermal Growth Factor (EGF)
9. lapatinib (GW572016)
10. gemcitabine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Heterologous Transplantation (Xenotransplantation)
4. Therapeutics
5. Immunotherapy