Cell Surface Receptors

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Also Known As:
Receptors, Cell Surface; Cell Surface Hormone Receptors; Endogenous Substances Receptors; Hormone Receptors, Cell Surface; Receptors, Endogenous Substances
Networked: 753 relevant articles (14 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Puri, Raj K: 5 articles (04/2012 - 10/2003)
2. Reynolds, Paul R: 4 articles (10/2014 - 05/2010)
3. Husain, Syed R: 4 articles (04/2012 - 10/2003)
4. Lam, Kit S: 4 articles (09/2007 - 01/2002)
5. Liu, Ruiwu: 4 articles (09/2007 - 05/2005)
6. Marik, Jan: 4 articles (09/2007 - 05/2005)
7. Varesio, Luigi: 3 articles (10/2014 - 03/2011)
8. Bosco, Maria Carla: 3 articles (10/2014 - 03/2011)
9. Marks, James D: 3 articles (10/2012 - 01/2010)
10. Hall, Walter A: 3 articles (10/2011 - 08/2003)

Related Diseases

1. Neoplasms (Cancer)
06/01/2011 - "Developments are currently being undertaken that aim to provide improved imaging methods for the detection and evaluation of tumors, for identifying important characteristics of tumors such as the expression levels of cell surface receptors that may dictate what types of therapy will be effective and for evaluating their response to treatments. "
07/15/2002 - "The permanent genetic programming via gene transfer of autologous T cells with cell surface receptors directed toward tumor-related Ags holds great promise for the development of more-specific tumor therapies. "
07/21/2014 - "This strategy is also a cost-effective and convenient operation, implying great promise for the sensitive recognition of cancer cells and cell surface receptors; thus, it is helpful in cancer diagnosis. "
05/01/2010 - "This strategy offers great promise for sensitive detection of cancer cells and cell surface receptors and thus may help improve cancer diagnosis and treatment."
01/01/1996 - "Control Group concentrations of sIL-2R were in the range of 101.9 to 255.3 IU/mL with a mean value of 178.6 IU/mL. Serum levels of sIL-2R were markedly elevated in the sera of children with solid tumors (Study Group) to levels between 223.8 IU/mL and 927 IU/mL with a mean value of 575.4 IU/mL. 1) The shedding of cell-surface receptors of immunological effector cells is a common physiological mechanism; 2) Presence of sIL-2R represents a sign of an overall activation of the effector elements of the host's cellular immune system; 3) An increase in the levels of sIL-2R represents an active phase of progression; conversely, decreasing levels indicate tumor regression; 4) Serum levels of sIL-2Rs may represent a useful laboratory parameter in choosing an efficient anti-cancer therapy. "
2. Glioma (Gliomas)
3. Lymphoma (Lymphomas)
4. Melanoma (Melanoma, Malignant)
5. Glioblastoma (Glioblastoma Multiforme)

Related Drugs and Biologics

1. Glucose (Dextrose)
2. Ligands
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4. Insulin (Novolin)
5. Cytokines
6. Antibodies
7. Chemokines
8. Hormones
9. Peptides
10. Interleukin-1 (Interleukin 1)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Biological Therapy
4. Transplants (Transplant)
5. Heterologous Transplantation (Xenotransplantation)