alpha Adrenergic Receptors

One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Also Known As:
Receptors, Adrenergic, alpha; Receptor, Adrenergic, alpha; Adrenergic alpha Receptors; Receptors, alpha Adrenergic; alpha-Receptors, Adrenergic; Adrenergic alpha-Receptors; Receptors, alpha-Adrenergic; alpha-Adrenergic Receptors
Networked: 150 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Feleder, Carlos: 3 articles (08/2015 - 10/2008)
2. Millington, William R: 3 articles (08/2015 - 10/2008)
3. Mestroni, Luisa: 2 articles (06/2011 - 01/2011)
4. Taylor, Matthew R G: 2 articles (06/2011 - 01/2011)
5. Cutrera, Rodolfo A: 2 articles (12/2009 - 10/2008)
6. Göktalay, Gökhan: 1 article (08/2015)
7. Sertac Yilmaz, M: 1 article (08/2015)
8. Peng, Jianya: 1 article (08/2015)
9. Vargas-Correa, Jorge Bernardo: 1 article (07/2015)
10. Rojo-Gutiérrez, María Isabel: 1 article (07/2015)

Related Diseases

1. Unstable Angina
2. Hypothermia
3. Hemorrhage
4. Seizures (Seizure)
01/01/1987 - "3. Ontogenic development of alpha adrenergic receptors indicate that an increased density of alpha-2 sites precedes the appearance of the first convulsions by approximately one week. "
10/01/1984 - "In the present study we have demonstrated that prazosin, a relatively specific blocker of post-synaptic alpha-adrenergic receptors, antagonized the anticonvulsant activity of DPH on 3 models of convulsions: convulsions in the quaking mouse, convulsions induced by pentylenetetrazol, convulsions provoked by electroshock. "
01/01/1977 - "From a study on the interrelationship between electroshock-induced convulsions, autonomic function, catecholamines, and cardiovascular homeostasis in dogs, the authors found that: (1) the asystole of electroshock (ES) was significnatly prolonged by high spinal anesthesia but not by relative alpha- or beta-adrenergic blockade; (2) increased levels of circulating catecholamines were solely responsible for the marked hypertensive response to ES, since the pressor effect could be blocked by preventing the release of catecholamines with high spinal anesthesia or by inhibiting alpha-adrenergic receptors with phenoxybenzamine; (3) the adrenal medulla appeared to be the source of most of the ES-induced increase in circulating catecholamines; (4) the asystole and arrhythmias of ES were a cholinergic effect, since they were blocked by atropine; (5) there was a dose-response relationship between the coulombs of electricity administered and the catecholamine and cardiovascular responses; and (6) that the adverse cardiovascular effects of ES therapy could be ameliorated pharmacologically."
5. Hemorrhagic Shock

Related Drugs and Biologics

1. Insulin (Novolin)
2. Calcium
3. Diltiazem (Cardizem)
4. Catecholamines
5. Prazosin (Minipress)
6. Phenoxybenzamine
7. Atropine (Hyoscyamine)
8. Neurotransmitter Receptors (Neurotransmitter Receptor)
9. Scopolamine (Hyoscine)
10. Pentylenetetrazole (Metrazol)

Related Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)
2. Spinal Anesthesia
3. Intravenous Infusions
4. Denervation
5. Castration