Radiodermatitis

A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.

Also Known As:

Radiation Recall Reaction; Dermatitides, Radiation Recall; Dermatitides, Radiation-Induced; Dermatitis, Radiation Induced; Dermatitis, Radiation Recall; Radiation Induced Dermatitis; Radiation Recall Dermatitides; Radiation Recall Reactions; Radiation-Induced Dermatitides; Radiodermatitides; Reaction, Radiation Recall; Reactions, Radiation Recall; Recall Reaction, Radiation; Recall Reactions, Radiation; Dermatitis, Radiation-Induced; Radiation Recall Dermatitis; Radiation-Induced Dermatitis

Networked: 488 relevant articles (47 outcomes, 75 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Breast Neoplasms (Breast Cancer)
2.	Neoplasms (Cancer)
3.	Mucositis
4.	Dermatitis
5.	Fibrosis (Cirrhosis)

Experts

1.	Mebis, Jeroen: 5 articles (01/2022 - 01/2017)
2.	Robijns, Jolien: 5 articles (01/2022 - 01/2017)
3.	Bulens, Paul: 3 articles (01/2022 - 01/2017)
4.	Lodewijckx, Joy: 3 articles (01/2022 - 01/2019)
5.	Maes, Annelies: 3 articles (01/2022 - 01/2017)
6.	González, Carol V Serna: 3 articles (06/2021 - 01/2020)
7.	Lopes, Luciana Biagini: 3 articles (06/2021 - 01/2020)
8.	Mattar, Rodrigo Calixto: 3 articles (06/2021 - 01/2020)
9.	Oh, Dongryul: 3 articles (06/2021 - 09/2013)
10.	Schmidt, Fernanda Mateus Queiróz: 3 articles (06/2021 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiodermatitis:

1.	Ointments (Pastes)IBA 01/01/2022 - "Our results indicate that Recove® ointment significantly reduces the severity of acute radiodermatitis." 02/01/2019 - "No patient was prescribed ointments as prophylactic treatment for radiation-induced dermatitis. " 01/01/1982 - "Treatment of acute radiodermatitis of first and second degrees with semi-greasy placenta ointment." 11/25/2020 - "This study aimed to observe the effect of topical application of a paste based on traditional Chinese medicine, Jiawei Simiao Yongan Gao, on radiodermatitis caused by radiotherapy for patients with head and neck cancer.This" 01/01/2022 - "Recove® burn ointment for managing acute radiodermatitis in patients with breast cancer: A double blind randomized controlled trial."
2.	SilymarinIBA 10/10/2023 - "Silymarin showed positive effects in ameliorating the damage of radiodermatitis, whereas the efficacy of calendula and aloe vera in the treatment of radiodermatitis lacks sufficient evidence. " 02/01/2019 - "Prophylactic administration of silymarin gel could significantly reduce the severity of radiodermatitis and delay its occurrence after 5 weeks of application." 02/01/2019 - "During this randomized, double-blinded, placebo-controlled clinical trial, the preventive effect of silymarin 1% gel was assessed in comparison with placebo, on radiodermatitis occurrence. " 02/01/2019 - "The scores increased significantly in both placebo and silymarin groups during radiotherapy, but there was a delay in radiodermatitis development and progression in silymarin group. " 02/01/2019 - "The purpose of this study was to investigate the efficacy of silymarin gel in prevention of radiodermatitis in patients with breast cancer. "
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2017 - "Prophylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: A randomized double blinded study." 03/22/2016 - "The timing, presentation and response of our patient's symptoms to corticosteroids are most consistent with a radiation recall reaction. " 01/01/2022 - "However, we have found that topically applied melatonin, a product that to our knowledge is not commercially available in Spain, is safe and effective in the prevention and treatment of radiodermatitis and a viable substitute for corticosteroid therapy. " 07/01/2020 - "Comparative Evaluation of Topical Corticosteroid and Moisturizer in the Prevention of Radiodermatitis in Breast Cancer Radiotherapy." 08/01/2023 - "Several studies suggest a role for topical corticosteroid ointments in the treatment of radiodermatitis. "
4.	Hyaluronic Acid (Hyaluronan)IBA 06/01/2009 - "At a time when the health care providers were faced with considerable treatment dilemmas, this patient demonstrated improvement in the symptoms of radiation recall dermatitis with the topical application of sodium hyaluronate and no change in her medication profile. " 12/01/2019 - "The aim of the study was to evaluate the effectiveness of hyaluronic acid gel (HAG) (Jalosome soothing gel) for the treatment of a case of radiodermatitis. " 06/01/2009 - "The use of sodium hyaluronate for the treatment of radiation recall dermatitis." 05/01/2022 - "Effect of hyaluronic acid on radiodermatitis in patients with breast cancer: a meta-analysis of randomized controlled trials." 01/01/2006 - "A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis."
5.	jaungoIBA 04/01/2019 - "This is a prospective, open-label, parallel-group, randomized controlled trial that evaluates the effectiveness and safety of adjuvant application of Jaungo (JUG) for radiation-induced dermatitis (RD) in breast cancer patients undergoing radiation therapy, in comparison with general supportive care (GSC). " 01/01/2021 - "Comparative Efficacy of Jaungo, A Traditional Herbal Ointment, and the Water-in-Oil Type Non-Steroidal Moisturizer for Radiation-Induced Dermatitis in Patients With Breast Cancer: A Study Protocol for a Prospective, Randomized, Single-Blinded, Pilot Study." 01/01/2023 - "Comparative efficacy of Jaungo, a traditional herbal ointment, and a water-in-oil type non-steroidal moisturizer for radiation-induced dermatitis in patients with breast cancer: a prospective, randomized, single-blind, pilot study."
6.	SilverIBA 02/01/2008 - "Silver leaf dressing does not appear to be superior to our standard treatment for radiation-induced dermatitis when the RTOG grading system is used. " 02/01/2008 - "Phase 2 study of silver leaf dressing for treatment of radiation-induced dermatitis in patients receiving radiotherapy to the head and neck." 11/01/2012 - "Silver clear nylon dressing is effective in preventing radiation-induced dermatitis in patients with lower gastrointestinal cancer: results from a phase III study." 12/01/2010 - "The primary objective of this study was to assess silver leaf nylon dressings as a prophylactic measure in reducing inframammary fold radiation induced dermatitis in women receiving adjuvant whole breast radiotherapy compared with standard skin care. " 12/01/2010 - "A prospective randomized trial compared silver leaf nylon dressing worn continuously from the sixth fraction of whole breast radiotherapy until 14 days after therapy completion to standard skin care in patients deemed to be at risk of inframammary radiation induced dermatitis by virtue of a large breast volume or a significant inframammary skin fold in the treatment position. "
7.	phytobacteriomycin (PBM)IBA 06/01/2021 - "This study aimed to evaluate the effect of photobiomodulation (PBM) for prevention of radiodermatitis in an irradiated mouse model and compare the efficacy of PBM using 633- or 830-nm wavelengths. " 07/01/2020 - "This pilot study showed that PBM therapy is safe and feasible in the clinic, and it might reduce the severity of radiodermatitis. " 06/01/2020 - "Objective: A narrative review of the available scientific evidence to identify the current proposals relating the use of photobiomodulation (PBM) to treat acute radiodermatitis (ARD), to guide future research. " 06/01/2021 - "This study indicates PBM could prevent severe radiodermatitis by reducing epidermal and dermal damage, inflammation, and apoptosis. " 07/01/2020 - "In this pilot study, we evaluated the clinical feasibility of photobiomodulation (PBM) therapy before conducting a randomized trial based on the hypothesis that PBM therapy may reduce the severity of radiodermatitis in participants receiving 60 Gy or higher dose. "
8.	Nylons (Nylon)IBA 11/01/2012 - "Silver clear nylon dressing is effective in preventing radiation-induced dermatitis in patients with lower gastrointestinal cancer: results from a phase III study." 12/01/2010 - "The primary objective of this study was to assess silver leaf nylon dressings as a prophylactic measure in reducing inframammary fold radiation induced dermatitis in women receiving adjuvant whole breast radiotherapy compared with standard skin care. " 12/01/2010 - "A prospective randomized trial compared silver leaf nylon dressing worn continuously from the sixth fraction of whole breast radiotherapy until 14 days after therapy completion to standard skin care in patients deemed to be at risk of inframammary radiation induced dermatitis by virtue of a large breast volume or a significant inframammary skin fold in the treatment position. "
9.	Cetuximab (Erbitux)FDA Link 11/01/2017 - "The present study aimed to evaluate the effect of topical RGTA on radiodermatitis in patients with HNC undergoing RT and cetuximab, for whom RT-induced skin reactions are frequent and/or severe. " 08/25/2023 - "Homologous platelet gel on radiation-induced dermatitis in a patient receiving head and neck radiotherapy plus cetuximab: A case report." 06/01/2017 - "Management of radiodermatitis associated with cetuximab in squamous cell carcinomas of the head and neck." 11/01/2017 - "Concomitant cetuximab and radiation therapy (RT) can induce severe radiodermatitis in patients with head and neck cancer (HNC). " 06/01/2017 - "The search employed the terms 'skin toxicity', 'radiodermatitis', 'cetuximab', 'radiotherapy', and 'head and neck cancer'. "
10.	Sesame Oil (Oil, Sesame)IBA 12/01/2023 - "Efficacy of sesame oil versus placebo in the management of acute radiation-induced dermatitis in breast cancer patients: A double-blind randomized clinical trial." 01/01/2022 - "This study aimed to evaluate the effect of topical Recove® burn ointment; basically compounded of sesame oil, camphor, and zinc oxide; in preventing acute radiodermatitis. "

Therapies and Procedures

1.	Radiotherapy 04/01/2019 - "The role of clinician-measured breast length and bra cup size in the development of radiodermatitis over time and the efficacy of using multiple measurements of skin toxicity during radiotherapy were piloted. " 12/01/2021 - "In this study, we evaluated the effect of these factors on the development of radiodermatitis in patients undergoing radiotherapy. " 11/20/2021 - "The current study aims to determine whether hypofractionated radiotherapy (HF) leads to lower rates of acute radiodermatitis compared to conventional normofractionated radiotherapy (CF). " 01/01/2021 - "This study aimed to investigate the impacts of team health education on radiodermatitis in patients undergoing head and neck radiotherapy. " 01/01/2020 - "In this study, we investigate the feasibility of using thermography as a tool to predict the response of normal breast tissue and skin to radiation therapy and the risk of developing radiation recall dermatitis. "
2.	Low-Level Light Therapy (LLLT) 02/01/2023 - "This study aimed to investigate the effect of the photobiomodulation with two wavelengths, in an acute radiodermatitis animal model. " 06/01/2021 - "Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study." 06/01/2020 - "A Narrative Review on the Use of Photobiomodulation Therapy for the Prevention and Management of Acute Radiodermatitis: Proposed Mechanisms, Current Clinical Outcomes, and Preliminary Guidance for Clinical Studies." 02/01/2023 - "Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment." 07/01/2020 - "Feasibility of photobiomodulation therapy for the prevention of radiodermatitis: a single-institution pilot study."
3.	Therapeutics 01/01/2022 - "Safe and effective prophylactic therapies for radiation-induced dermatitis (RID) remain an unmet need. " 12/01/2012 - "In this study, we evaluate a method for the early diagnosis of radiodermatitis for use in the prevention and therapy of this condition. " 08/01/2023 - "Herbal monotherapy and combination therapy were reported, and their effects on radiodermatitis were explained in the systematic review. " 06/01/2023 - "Radiation recall reactions are inflammatory reactions confined to previously irradiated tissues, often of drug-induced etiology, particularly with anticancer therapies. " 03/07/2022 - "There are no established therapies for the treatment of radiation induced dermatitis. "
4.	Dye Lasers 06/01/2006 - "Pulsed-dye laser is a safe and effective treatment for chronic radiodermatitis of the neck after radiotherapy." 01/01/2017 - "Also, in late-onset radiodermatitis pulsed dye laser treatment has been shown to be beneficial in clearing radiation-induced telangiectasia. "
5.	Segmental Mastectomy (Lumpectomy) 05/01/2016 - "The present study describes the case of a 37-year-old woman with radiation recall dermatitis that occurred 6 years and 4 months after breast-conserving surgery. " 05/08/2023 - "The role of ultrasound quantitative parameters in the assessment of acute radiodermatitis after breast-conserving surgery." 05/01/2016 - "Radiation recall dermatitis occurring 6 years and 4 months after breast-conserving surgery: A case report." 07/01/2009 - "Within 3 weeks, the patient developed an ulcerative radiation recall reaction in the skin overlying the lumpectomy cavity. " 01/01/2022 - "To evaluate the efficacy of photobiomodulation therapy in breast cancer patients post-lumpectomy undergoing hypofractionated whole-breast irradiation (HF-WBI) for the prevention and management of acute radiodermatitis (ARD). "