Radiculopathy (Radiculopathy, Cervical)

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738 relevant articles (41 outcomes, 83 trials/studies) found for this Disease

Description: Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.

Also Known As:

Radiculopathy, Cervical; Cervical Radiculopathy; Nerve Root Inflammation; Avulsion, Nerve Root; Avulsions, Nerve Root; Cervical Radiculopathies; Compression, Nerve Root; Compressions, Nerve Root; Inflammation, Nerve Root; Nerve Root Avulsions; Nerve Root Compressions; Nerve Root Disorders; Nerve Root Inflammations; Radiculitides; Radiculopathies; Radiculopathies, Cervical; Nerve Root Avulsion; Nerve Root Compression; Nerve Root Disorder; Radiculitis

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3422

Neuromuscular Diseases: 744

Peripheral Nervous System Diseases: 3233

Radiculopathy: 738

Related Diseases

1.	Pain (Aches)
2.	Spinal Cord Diseases
3.	Syndrome
4.	Low Back Pain (Lumbago)
5.	Intervertebral Disk Displacement (Herniated Disc)

Experts

1.	Shi, Qi: 2 articles (03/2006 - 09/2004)
2.	Wang, Yong-Jun: 2 articles (03/2006 - 09/2004)
3.	Zhou, Chong-Jian: 2 articles (03/2006 - 09/2004)
4.	Naruse, Satoshi: 2 articles (10/2005 - 01/2003)
5.	Yoshizawa, Hidezo: 2 articles (03/2005 - 02/2005)
6.	Baba, Hisatoshi: 2 articles (03/2005 - 02/2005)
7.	Kobayashi, Shigeru: 2 articles (03/2005 - 02/2005)
8.	DeLeo, J A: 2 articles (10/2001 - 08/2000)
9.	Rutkowski, M D: 2 articles (10/2001 - 08/2000)
10.	Weinstein, J N: 2 articles (10/2001 - 08/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiculopathy:

1.	SteroidsIBA 12/01/2000 - "Epidural steroids may be beneficial for subgroups of nerve root compression" 03/01/2007 - "Further studies have to be performed before excluding steroids in such treatment and for evaluating the influence of local anaesthetics on radiculopathy in transforaminal injections." 11/01/2004 - "Epidural steroids should be considered only in radiculopathy" 05/01/2004 - "There is only one RCT for radiculopathy and epidural steroids." 07/01/2002 - "Intra-thecal steroids have been frequently used in the treatment of lumbar radiculopathy due to discopathy, as an alternative treatment when epidural administration is ineffective" Order ALL the reference details at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/15/1996 - "There is conflicting evidence regarding epidural injection of corticosteroids, but one meta-analysis suggests they may provide a small symptomatic improvement for patients with radiculopathy" 05/01/2007 - "The purpose of this study was to evaluate treatment outcomes with intradiscal injection of corticosteroids (IDIC) in cervical spondylotic radiculopathy" 01/01/1990 - "The epidural administration of corticosteroids in treating discogenic radiculitis]" 04/01/1979 - "Few serious complications have been associated with the intrathecal administration of corticosteroids in the treatment of lumbar radiculopathy" 03/01/1993 - "In addition, many surgeons routinely use intraoperative corticosteroids during lumbar discectomy to reduce traumatic nerve root inflammation" Order ALL the reference details at left...
3.	FlexorIBA 09/01/1999 - "The focus of this study was to identify the OSP that effects the maximum recovery of the flexor carpi radialis (FCR) H-reflex and to study its effect on the disability status in patients with cervical radiculopathy" 04/01/1996 - "With C-5, C-7, and C-8 radiculopathies, changes were relatively stereotyped, with involvement of the spinati,deltoid, biceps, and brachioradialis with C-5; the pronator teres, flexor carpi radialis, triceps, and anconeus with C-7; and the first dorsal interosseous, abductor digiti minimi, abductor pollicis brevis, flexor pollicis longus, and extensor indicis proprius with C-8" 03/01/1990 - "These results indicate that flexor carpi radialis, vastus medialis, and soleus H-reflexes are useful and valid methods for testing C7, L4, and S1 radiculopathy." 03/01/1990 - "The H-reflex was recorded from the flexor carpi radialis, vastus medialis, and soleus muscles in patients with radiculopathy at C7, L4, and S1 roots" 12/01/2007 - "The study design did not allow for the identification of a cause-and-effect relationship, but it appears that intermittent cervical traction, manual therapy, and deep neck flexor muscle strengthening may be beneficial in the management of cervical radiculopathy" Order ALL the reference details at left...
4.	Chymopapain (Chymodiactin)FDA Link 08/01/1985 - "Most cases of treatment failure could be attributed to an incorrect radiographic diagnosis, treatment of patients with equivocal diagnostic studies, the presence of "free" disk fragments, and causes of nerve-root compression unresponsive to chymopapain." 01/01/1975 - "Experimental studies on the effect of chymopapain on nerve root compression caused by intervertebral disk material." 01/01/1975 - "Since the primary effect of chymopapain is on the chondromucoprotein of the disk, beneficial results would not be expected if nerve root compression is due to bony impingement or scar tissue following previous surgery" 07/01/1985 - "Ten normal adult volunteers, 75 patients with low back pain and/or lumbar radiculopathy, 16 patients following chymopapain treatment, 14 patients with recurrent symptoms following disc surgery, and two patients with distal cord compression were scanned on Fonar 3000 permanent magnet scanner" Order ALL the reference details at left...
5.	TitaniumIBA 11/01/2007 - "OBJECTIVE: To introduce and evaluate the efficacy of microsurgical decompression and titanium cage implants fusion with anterior plating in cervical spondylitic radiculopathy" 03/01/2008 - "CONCLUSION: This study showed no statistically significant difference between simple discectomy and discectomy followed by interbody fusion with a titanium cage in the surgical treatment of cervical radiculopathy caused by disc herniation." 03/01/2008 - "METHODS: Eighty-six patients with symptoms of nerve root compression at 1 level were randomly allocated to either discectomy followed by fusion with a Ray titanium cage (40 patients) or to discectomy alone (46 patients)" 03/01/2008 - "OBJECTIVE: To compare 2 surgical methods in the treatment of cervical radiculopathy caused by hard or soft disc herniation; namely, simple discectomy versus discectomy with an additional interbody fusion with a Ray titanium cage" 10/01/2003 - "We retrospectively reviewed eight patients with cervical radiculopathy operated upon with anterior discectomy and fusion with a stand-alone titanium cervical cage" Order ALL the reference details at left...
6.	beta-tricalcium phosphateIBA 05/01/2008 - "The objective of this prospective, randomized clinical study was to evaluate the effectiveness of implanting interbody fusion cage containing beta-TCP for the treatment of cervical radiculopathy and/or myelopathy, and the fusion rates and outcomes in patients with or without randomly assigned plate fixation" 05/01/2008 - "Based on the findings of this study, interbody fusion cage containing beta-TCP following one- or two-level discectomy proved to be an effective treatment for cervical spondylotic radiculopathy and/or myelopathy" 05/01/2008 - "Sixty-two patients with cervical radiculopathy and/or myelopathy due to soft disc herniation or spondylosis were treated with one- or two-level discectomy and fusion with interbody cages containing beta-TCP" Order ALL the reference details at left...
7.	lamotrigine (Lamictal)FDA LinkGeneric 01/01/2003 - "Study results suggest lamotrigine is a potentially effective and safe compound for the treatment of painful lumbar radiculopathy, and that it is likely to act in a dose- and plasma concentration-dependent fashion." Order ALL the reference details at left...
8.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/01/1961 - "On the problem of the treatment of lumbosacral radiculitis by epidural infusions of vitamin B12.]" 01/01/1966 - "On the effectiveness of treating patients with lumbosacral radiculitis with novocaine blockades, variously modified, and vitamin B 12]" 03/01/1965 - "THE TREATMENT OF ACUTE LUMBOSACRAL RADICULITIS USING DIA-DYNAMIC CURRENTS AND VITAMIN B 12 UNDER AMBULATORY CONDITIONS.]" 09/01/1963 - "ON THE TREATMENT OF LUMBOSACRAL RADICULITIS WITH EPIDURAL INJECTION OF VITAMIN B 12 AND NOVOCAINE.]" 07/14/1984 - "The therapeutic efficacy of two neurotrophic substances (exogenic gangliosides and Vitamin B12) is examined in 30 cases of patients suffering from postoperative radiculopathy after the excision of herniated discs" Order ALL the reference details at left...
9.	Analgesics (Analgesic Drugs)IBA 01/01/1994 - "Cervical radiculopathy treated by infusion of epidural analgesics in homebound patients." 01/01/1994 - "CONCLUSIONS: Patients with chronic persistent cervical radiculopathy pain were effectively treated with infusion of analgesics through epidural catheters for 2 to 17 days while they were at home." 12/01/2002 - "Patients with radiculopathy, who did not respond to physical therapy, antiinflammatories, or analgesics, caused by degenerative lumbar stenosis and confirmed by magnetic resonance imagining received fluoroscopically guided lumbar transforaminal epidural steroid injections at the presumed symptomatic nerve root" 02/18/1997 - "Epidural administration of corticosteroids with longterm effect and bupivacaine by a translumbar approach in patients suffering from acute low back pain and sciatica causes an immediate, persistent pain relief and a more prompt regression of nerve root compression compared to patients just treated by bed rest and analgesics" Order ALL the reference details at left...
10.	gabapentin (Neurontin)FDA LinkGeneric 05/01/2008 - "Complications included bilateral lower extremity lumbar radiculopathy in one patient that resolved with a short course of gabapentin, spinal headache in one patient that resolved with bed rest and fluids, and development of a small intracranial subdural hygroma without mass effect in one patient that is asymptomatic and being followed without clinical consequence" 10/01/2008 - "In nerve root compressions, additional local application of steroids and preoperative gabapentin seems sensible" 10/02/2007 - "We also found fair evidence that opioids, tramadol, benzodiazepines, and gabapentin (for radiculopathy) are effective for pain relief" Order ALL the reference details at left...

Therapies and Procedures

1.	Diskectomy (Discectomy) 10/01/2003 - "Percutaneous lumbar diskectomy techniques hold considerable promise; however, lumbar microdiskectomy is the gold standard for surgical treatment of lumbar disk protrusion with radiculopathy" 07/01/2007 - "The purpose of this study was to assess clinical and radiographic outcomes in patients with cervical radiculopathy after discectomy without fusion (ACD), discectomy with intervertebral fusion (ACDF), and discectomy with intervertebral fusion and instrumentation (ACDFI)" 10/01/2001 - "METHODS: A 49-year-old male with a left-sided C8 radiculopathy had dynamic X-ray, MR, and CT studies that documented an old anterior diskectomy and fusion at the C5-C6 level, and a new left-sided foraminal disc herniation at the C7-T1 level with instability, accompanied by C6-T1 spondylostenosis" 04/01/2000 - "STUDY DESIGN: A prospective assessment, performed using the Health Status Questionnaire, of the outcomes for 28 patients with cervical radiculopathy treated with one- or two-level anterior cervical discectomy and fusion" 02/01/1996 - "STUDY DESIGN: Herniated lumbar disc specimens were obtained from patients undergoing surgical discectomy for persistent radiculopathy and cultured in vitro to determine whether various biochemical agents were being produced" Order ALL the reference details at left...
2.	Laminectomy 09/01/1997 - "Although the strong association of worker's compensation with poor results made it difficult to assess the importance of other risk factors, the data suggest that good results may be more likely in patients with radiculopathy who undergo laminectomy" 01/01/1988 - "The amount of spinal canal expansion obtained by the laminaplasty procedure ranged from 4 to 12 mm. The conclusions of this study were (a) laminaplasty appears to be an effective alternative to laminectomy or anterior cervical fusion for multilevel cervical spondylotic radiculopathy or myeloradiculopathy and (b) complications of anterior fusion and laminectomy are avoided with the laminoplasty procedure." 04/15/1996 - "This study shows that the patients' self-reported health outcomes after lumbar laminectomy correlate with the excellent results previously seen using physician-driven outcome measures in an appropriately selected population with radiculopathy" 04/15/1996 - "Although surgical treatment for radiculopathy by lumbar laminectomy has been shown to be successful using specific criteria for patient selection and an algorithmic approach, the authors are not aware of any study using a patient-based health outcome assessment to evaluate the results of this type of surgery" 02/01/1977 - "This study included seventeen patients undergoing partial laminectomy for radiculopathy secondary to herniated nucleus pulposis" Order ALL the reference details at left...
3.	Decompression 04/01/2002 - "OBJECTIVES: To describe a contemporary posterolateral endoscopic decompression technique for radiculopathy secondary to lumbar disc herniation; to evaluate the efficacy of the technique as it is applied to lumbar disc herniation including primary herniation, reherniation, intracanal herniation, and extracanal herniation; and to report outcome and complications" 11/01/1993 - "Nerve-root compression due to recurrent disc herniation or to bony compression responded well to repeat decompression" 09/01/1997 - "STUDY DESIGN: Thirty-three patients with single-level, unilateral lumbosacral radiculopathy underwent micro-decompression and intraoperative dermatomal evoked potential monitoring" 06/01/2008 - "OBJECTIVE: The purpose of this report was to describe the use of Cox flexion distraction decompression manipulation on a patient with radiculopathy from a C6/C7 disc herniation" 11/01/2007 - "CONCLUSION: The technique of microsurgical cervical nerve root decompression by selective microforaminotomy via an anterolateral approach is safe and efficient for the treatment of spondylotic radiculopathy" Order ALL the reference details at left...
4.	Musculoskeletal Manipulations (Manipulative Therapy) 11/01/2003 - "CONCLUSION: The results of this study show promise for chiropractic and manual therapy techniques such as flexion distraction, as well as demonstrating that other, larger research studies must be performed for cervical radiculopathy." 07/01/2006 - "OBJECTIVE: Conventional treatment methods of lumbusacral radiculopathy are physical therapy, epidural steroid injections, oral medications, and spinal manipulative therapy" 03/01/2006 - "ICT and manual therapy (including thoracic TJM) are widely used in clinical settings to treat cervical radiculopathy" 11/01/1997 - "OBJECTIVE: To discuss the combined use of selective epidural steroid injection (ESI) and spinal manipulative therapy (SMT) in treating recalcitrant lumbar radiculopathy" 05/01/1995 - "Certain conditions, including cervical radiculopathy, seem to respond well to chiropractic spinal manipulative therapy" Order ALL the reference details at left...
5.	Traction 12/01/2004 - "OBJECTIVE: To determine if combining intermittent cervical traction with conventional physical therapy methods is more effective than using conventional approaches alone in the improvement of the grip strength and treatment of the patients with unilateral cervical 7 (C7) radiculopathy" 12/01/2005 - "However, because a cause-and-effect relationship cannot be inferred from a case series, follow-up randomized clinical trials should be performed to further investigate the effectiveness of manual physical therapy, cervical traction, and strengthening exercises in a homogeneous group of patients with cervical radiculopathy." 04/01/2008 - "As a result, the Slump test applies traction to the nerve roots by incorporating spinal and hip joint flexion into the leg raising and would warn the examiner of the presence of nerve root compression when there is a negative SLR test" 03/01/2007 - "This review suggests that, when consistent with the history and other physical findings, a positive Spurling's, traction/neck distraction, and Valsalva's might be indicative of a cervical radiculopathy, while a negative ULTT might be used to rule it out" 12/01/2005 - "CASE DESCRIPTION: Eleven consecutive patients (mean age, 51.7 years; SD, 8.2) who presented with cervical radiculopathy on the initial examination were treated with a standardized approach, including manual physical therapy, cervical traction, and strengthening exercises of the deep neck flexors and scapulothoracic muscles" Order ALL the reference details at left...

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