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Quadriplegia (Locked In Syndrome)

Severe or complete loss of motor function in all four limbs which may result from BRAIN DISEASES; SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or rarely MUSCULAR DISEASES. The locked-in syndrome is characterized by quadriplegia in combination with cranial muscle paralysis. Consciousness is spared and the only retained voluntary motor activity may be limited eye movements. This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts.
Also Known As:
Locked In Syndrome; Spastic Quadriplegia; Tetraplegia; Quadriparesis; Flaccid Tetraplegia; Spastic Tetraplegia; Syndrome, Locked-In; Flaccid Quadriplegia; Paralysis, Spinal, Quadriplegic; Flaccid Quadriplegias; Flaccid Tetraplegias; Locked-In Syndromes; Quadripareses; Quadriplegia, Flaccid; Quadriplegia, Spastic; Quadriplegias; Quadriplegias, Flaccid; Quadriplegias, Spastic; Spastic Quadriplegias; Spastic Tetraplegias; Syndromes, Locked-In; Tetraplegia, Flaccid; Tetraplegia, Spastic; Tetraplegias; Tetraplegias, Flaccid; Tetraplegias, Spastic; Locked-In Syndrome
Networked: 1077 relevant articles (36 outcomes, 60 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Muscle Spasticity (Spastic)
2. Respiratory Insufficiency (Respiratory Failure)
3. Spinal Cord Injuries (Spinal Cord Injury)
4. Hemiplegia (Spastic Hemiplegia)
5. Wounds and Injuries (Trauma)

Experts

1. Bauman, William A: 15 articles (09/2015 - 01/2005)
2. Spungen, Ann M: 10 articles (03/2011 - 01/2004)
3. Wecht, Jill M: 9 articles (09/2015 - 01/2005)
4. Radulovic, Miroslav: 8 articles (09/2015 - 01/2005)
5. Schilero, Gregory J: 6 articles (09/2015 - 01/2004)
6. DiMarco, Anthony F: 6 articles (09/2009 - 12/2002)
7. Berlowitz, David J: 5 articles (01/2014 - 01/2013)
8. Vaidyanathan, Subramanian: 5 articles (01/2012 - 09/2002)
9. Rosado-Rivera, Dwindally: 5 articles (11/2011 - 02/2009)
10. Lesser, Marvin: 5 articles (11/2009 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Quadriplegia:
1. BaclofenFDA LinkGeneric
2. Anti-Bacterial Agents (Antibiotics)IBA
3. NG-Nitroarginine Methyl Ester (L-NAME)IBA
4. PotassiumIBA
5. Glucose (Dextrose)FDA LinkGeneric
6. Norepinephrine (Noradrenaline)FDA LinkGeneric
7. levodopa drug combination carbidopa (Nakom)FDA LinkGeneric
8. Niacin (Nicotinic Acid)FDA LinkGeneric
9. Epinephrine (Adrenaline)FDA LinkGeneric
10. Tissue Plasminogen Activator (Alteplase)FDA Link

Therapies and Procedures

1. Aftercare (After-Treatment)
2. Activities of Daily Living (ADL)
3. Drug Therapy (Chemotherapy)
4. Self-Help Devices (Assistive Technology)
5. Artificial Respiration (Mechanical Ventilation)