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Pyruvate Oxidase

Also Known As:

Oxidase, Pyruvate

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on Aldehyde or Oxo Group Donors
      - Ketone Oxidoreductases
        Pyruvate Oxidase: 12
        E coli 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase

Experts

1.	Anil, Anjali: 1 article (11/2021)
2.	Apte, Shruti: 1 article (11/2021)
3.	Banerjee, Anirban: 1 article (11/2021)
4.	Joseph, Jincy: 1 article (11/2021)
5.	Madhavan, Shilpa: 1 article (11/2021)
6.	Parthasarathy, Akhila: 1 article (11/2021)
7.	Cornacchione, Louis P: 1 article (01/2019)
8.	Duncan, Margaret J: 1 article (01/2019)
9.	Hu, Linden T: 1 article (01/2019)
10.	Klein, Brian A: 1 article (01/2019)

Related Diseases

1.	Tyrosinosis 12/01/1981 - "[Association, in the same subject, of deletion of the short arm of chromosome 4 (4p-) and of complete deficiency of parahydroxyphenyl-pyruvate oxidase activity in the liver (tyrosinosis)]." 04/10/1965 - "STUDIES ON TYROSINOSIS: 2, ACTIVITY OF THE TRANSAMINASE, PARAHYDROXY-PHENYL-PYRUVATE OXIDASE, AND HOMOGENTISIC-ACID OXIDASE."
2.	Infections 01/01/2016 - "Infection with either a mutant lacking spxB, which encodes pyruvate oxidase responsible for H2O2 production, or Streptococcus mutans, which does not produce H2O2, showed less cytotoxicity. " 03/01/1981 - "Thiamine deficiency induces a biochemical lesion (Peters) in the pyruvate oxidase system of the muscle, which breaks down its normal resistance to infection and opens the gate to bacterial agents. " 10/01/2009 - "Relative expression levels of genes encoding virulence factors, PsaA (surface adhesion), SpxB (pyruvate oxidase), Ply (pneumolysin), and LytA (autolysin) were assessed separately in epithelium-attached and supernatant bacteria 3h post infection using real-time PCR. "
3.	Thiamine Deficiency 03/01/1981 - "Thiamine deficiency induces a biochemical lesion (Peters) in the pyruvate oxidase system of the muscle, which breaks down its normal resistance to infection and opens the gate to bacterial agents. "
4.	Starvation 11/01/2004 - "Diversion of the metabolic flux from pyruvate dehydrogenase to pyruvate oxidase decreases oxidative stress during glucose metabolism in nongrowing Escherichia coli cells incubated under aerobic, phosphate starvation conditions."
5.	Pneumococcal Infections 11/19/2021 - "Thus, pyruvate oxidase is a key virulence determinant and can potentially serve as a viable candidate for therapeutic interventions for better management of invasive pneumococcal diseases."

Related Drugs and Biologics

1.	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)
2.	Transaminases (Aminotransferases)
3.	Hydrogen Peroxide (Hydroperoxide)
4.	Virulence Factors (Pathogenicity Factors)
5.	Pyruvic Acid (Pyruvate)
6.	Glutamic Acid (Glutamate)
7.	Phosphates (Orthophosphate)
8.	Oxidoreductases (Dehydrogenase)
9.	N-Acetylmuramoyl-L-alanine Amidase (Autolysin)
10.	Ligases (Synthetase)