|1.||Vander Heiden, Matthew G: 15 articles (11/2015 - 03/2008)|
|2.||Cantley, Lewis C: 13 articles (10/2013 - 03/2008)|
|3.||Lu, Zhimin: 9 articles (05/2015 - 12/2011)|
|4.||Bamezai, Rameshwar N K: 8 articles (08/2015 - 05/2009)|
|5.||Yang, Weiwei: 7 articles (05/2015 - 12/2011)|
|6.||Gros, Philippe: 7 articles (01/2015 - 12/2003)|
|7.||Mazurek, Sybille: 6 articles (08/2014 - 03/2003)|
|8.||Thomas, Craig J: 6 articles (08/2013 - 02/2010)|
|9.||Min-Oo, Gundula: 6 articles (04/2008 - 12/2003)|
|10.||Mazurek, S: 6 articles (08/2004 - 11/2000)|
03/15/1998 - "Delayed onset of hemolytic anemia in CBA-Pk-1slc/Pk-1slc mice with a point mutation of the gene encoding red blood cell type pyruvate kinase."
06/01/2014 - "A two-year-old male baby with severe hemolytic anemia and low level of pyruvate kinase (PK) activity was enrolled in this study. "
05/08/1999 - "[Molecular study of red cell pyruvate kinase deficiency in 15 patients with chronic hemolytic anemia. "
04/01/1995 - "Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia."
01/01/1995 - "Study of the molecular defects in pyruvate kinase deficient patients affected by nonspherocytic hemolytic anemia."
06/01/2010 - "In vivo and in vitro data have suggested that pyruvate kinase deficiency, which causes a nonspherocytic haemolytic anaemia, could be protective against malaria severity in humans, but this hypothesis remains to be tested. "
05/01/2004 - "Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model."
02/01/2000 - "In a field study in Nigeria, we determined G6PD gene variants, the corresponding G6PD and pyruvate kinase (PK) activities, and basic haematological parameters in clinically healthy individuals, who were, in part, asymptomatically infected by malaria parasites. "
01/01/2015 - "Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population."
06/01/2014 - "Thus, factors reducing the activity (loss of function) or level of pyruvate kinase have been selected to provide resistance against malaria primarily in endemic regions. "
06/01/2005 - "One such example is the case of pyruvate kinase, where a loss-of-function mutation was recently shown by our group to be protective against blood-stage infection with Plasmodium chabaudi. "
05/01/2009 - "Pyruvate kinase deficiency has been shown to provide protection against Plasmodium falciparum infection. "
04/24/2008 - "Here, we show that pyruvate kinase deficiency provides protection against infection and replication of P. "
10/01/2015 - "Here, we show that the HIF-1 metabolic effector, pyruvate kinase 2 (PKM2), is upregulated upon KSHV infection of endothelial cells and is necessary to maintain aerobic glycolysis in infected cells. "
10/24/2014 - "Knock-outs of regulators of this metabolic branch point and of its central enzyme, pyruvate kinase (ΔpykF), result in mutants with significantly reduced virulence in an oral mouse infection model. "
02/09/2012 - "In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contributes to the regulation of cancer cell metabolism. "
03/01/2009 - "Recent studies have confirmed that alterations in the isoenzyme of pyruvate kinase (PK) provide tumor cells with selective growth advantage. "
08/01/2008 - "Additionally, the 4-fold higher level of pyruvate kinase amount in the cancer homogenate reported in this study is considerably higher than the 2-fold higher ratio reported across 20 cancer samples in the discovery phase with the iTRAQ technique, suggesting that there exists a possibility that the dynamic range of ratios determined by the iTRAQ technique may have been compressed."
07/15/2008 - "In the present study, we developed the first specific inhibitors of the pyruvate kinase isoenzyme type M2 and present evidence that these inhibitors moderately decelerate tumor cell proliferation."
12/01/2015 - "Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme that regulates the Warburg effect and is necessary for tumor growth. "
12/01/1986 - "Hypoxia also resulted in enzyme elevations of lung phosphofructokinase and pyruvate kinase, which may indicate an adaptive increase in lung glycolytic capabilities which would be helpful in maintaining lung tissue energy requirements during hypoxia. "
07/01/2007 - "The response of Crassostrea gigas to prolonged hypoxia was investigated for the first time by analyzing the metabolic branch point formed by pyruvate kinase (PK) and hosphoenolpyruvate carboxykinase (PEPCK). "
10/01/2004 - "In particular, pyruvate kinase (PK) was upregulated by hypoxia in CCF-STTG1 cells. "
06/01/2000 - "The effects of seasonal change, November versus July, and prolonged anoxia (96 h under N2 gas) on the properties of phosphofructokinase and pyruvate kinase from five tissues (gill, mantle, hepatopancreas, phasic adductor, catch adductor) of the oyster, Crassostrea virginica were investigated. "
06/01/2000 - "Seasonal change and prolonged anoxia affect the kinetic properties of phosphofructokinase and pyruvate kinase in oysters."
|3.||Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
|7.||Proteins (Proteins, Gene)
|9.||Fatty Acid Synthetase Complex (Fatty Acid Synthase)
|10.||Phosphopyruvate Hydratase (Enolase)
|2.||Drug Therapy (Chemotherapy)
|4.||Transplantation (Transplant Recipients)
|5.||Heterologous Transplantation (Xenotransplantation)