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Pyruvate Kinase

ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Also Known As:
L-Type Pyruvate Kinase; M-Type Pyruvate Kinase; M1-Type Pyruvate Kinase; M2-Type Pyruvate Kinase; Pyruvate Kinase L; R-Type Pyruvate Kinase; L Type Pyruvate Kinase; M Type Pyruvate Kinase; M1 Type Pyruvate Kinase; M2 Type Pyruvate Kinase; Pyruvate Kinase, L-Type; Pyruvate Kinase, M-Type; Pyruvate Kinase, M1-Type; Pyruvate Kinase, M2-Type; Pyruvate Kinase, R-Type; R Type Pyruvate Kinase
Networked: 1058 relevant articles (24 outcomes, 71 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Vander Heiden, Matthew G: 15 articles (11/2015 - 03/2008)
2. Cantley, Lewis C: 13 articles (10/2013 - 03/2008)
3. Lu, Zhimin: 9 articles (05/2015 - 12/2011)
4. Bamezai, Rameshwar N K: 8 articles (08/2015 - 05/2009)
5. Yang, Weiwei: 7 articles (05/2015 - 12/2011)
6. Gros, Philippe: 7 articles (01/2015 - 12/2003)
7. Mazurek, Sybille: 6 articles (08/2014 - 03/2003)
8. Thomas, Craig J: 6 articles (08/2013 - 02/2010)
9. Min-Oo, Gundula: 6 articles (04/2008 - 12/2003)
10. Mazurek, S: 6 articles (08/2004 - 11/2000)

Related Diseases

1. Hemolytic Anemia
2. Malaria
3. Infection
4. Neoplasms (Cancer)
5. Anoxia (Hypoxia)

Related Drugs and Biologics

1. Enzymes
2. Hexokinase
3. Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
4. Glucose (Dextrose)
5. Isoenzymes
6. Oxidoreductases
7. Proteins (Proteins, Gene)
8. Alanine (L-Alanine)
9. Fatty Acid Synthetase Complex (Fatty Acid Synthase)
10. Phosphopyruvate Hydratase (Enolase)

Related Therapies and Procedures

1. Splenectomy
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Transplantation (Transplant Recipients)
5. Heterologous Transplantation (Xenotransplantation)