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Pyruvate Kinase

ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Also Known As:
L-Type Pyruvate Kinase; M-Type Pyruvate Kinase; M1-Type Pyruvate Kinase; M2-Type Pyruvate Kinase; Pyruvate Kinase L; R-Type Pyruvate Kinase; L Type Pyruvate Kinase; M Type Pyruvate Kinase; M1 Type Pyruvate Kinase; M2 Type Pyruvate Kinase; Pyruvate Kinase, L-Type; Pyruvate Kinase, M-Type; Pyruvate Kinase, M1-Type; Pyruvate Kinase, M2-Type; Pyruvate Kinase, R-Type; R Type Pyruvate Kinase
Networked: 1810 relevant articles (30 outcomes, 149 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Vander Heiden, Matthew G: 24 articles (01/2022 - 03/2008)
2. Cantley, Lewis C: 14 articles (01/2022 - 03/2008)
3. Li, Zhuoyu: 12 articles (03/2022 - 09/2014)
4. Bamezai, Rameshwar N K: 12 articles (01/2018 - 05/2009)
5. Israelsen, William J: 10 articles (01/2022 - 11/2011)
6. Bianchi, Paola: 10 articles (01/2020 - 06/2005)
7. Fermo, Elisa: 10 articles (01/2020 - 06/2005)
8. Kung, Charles: 9 articles (11/2022 - 10/2012)
9. Yang, Peng: 9 articles (10/2020 - 09/2014)
10. Baldissera, Matheus D: 9 articles (02/2020 - 04/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Pyruvate Kinase Deficiency of Red Cells
3. Hemolytic Anemia
4. Colorectal Neoplasms (Colorectal Cancer)
5. Insulin Resistance

Related Drugs and Biologics

1. Enzymes
2. Hexokinase
3. Glucose (Dextrose)
4. Isoenzymes
5. Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)
6. mitapivat
7. Insulin (Novolin)
8. Proteins (Proteins, Gene)
9. shikonin
10. Phosphofructokinases

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Splenectomy
3. Radiotherapy
4. Therapeutics
5. Hysterectomy