Pyruvate Dehydrogenase (Lipoamide)-Phosphatase (Pyruvate Dehydrogenase Phosphatase)

(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cebotaru, Liudmila: 1 article (01/2022)
2.	Cole, Robert: 1 article (01/2022)
3.	Guggino, William B: 1 article (01/2022)
4.	Han, Fang: 1 article (01/2022)
5.	Hou, Yanyan: 1 article (01/2022)
6.	Li, Dongze: 1 article (01/2022)
7.	Lu, Wenxue: 1 article (01/2022)
8.	Lv, Changjun: 1 article (01/2022)
9.	Qu, Guiwu: 1 article (01/2022)
10.	Ren, Wenjing: 1 article (01/2022)

Related Diseases

1.	Starvation 06/01/2003 - "This study examined whether altered pyruvate dehydrogenase phosphatase (PDP) expression also contributes to changes in the phosphorylation state of PDC during starvation and diabetes. " 06/01/2003 - "Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney." 08/01/1995 - "Starvation reduces pyruvate dehydrogenase phosphate phosphatase activity in rat kidney." 03/30/1979 - "Reduction of mitochondrial pyruvate dehydrogenase phosphatase activity in lactating rat mammary gland following starvation or insulin deprivation." 08/15/1978 - "5. Starvation led to a decline in activity of pyruvate dehydrogenase phosphatase in mitochondrial extracts, but not in whole-tissue extracts. "
2.	Insulin Resistance 12/01/2016 - "Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes." 04/01/2005 - "Down-regulation of pyruvate dehydrogenase phosphatase in obese subjects is a defect that signals insulin resistance." 03/01/1996 - "Inhibition by fraction V3 of Mg(2+)-stimulated PDH phosphatase and its cloned catalytic subunit helps explain its mechanism of action to inhibit insulin-stimulated oxidative glucose metabolism in adipocytes and its potential clinical significance in insulin resistance."
3.	Hypoxia (Hypoxemia) 01/01/2023 - "Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia." 01/01/2022 - "Mechanistically, the results showed that pyruvate dehydrogenase complex E1ɑ subunit (PDHA1) and the pyruvate dehydrogenase complex (PDC) activator pyruvate dehydrogenase phosphatase 1 (PDP1) did not noticeable change after intermittent hypoxia. " 04/01/2015 - "Hypoxia-inducible factor-1 alpha (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) regulate aerobic glycolysis, while pyruvate dehydrogenase phosphatase 2 (PDP2) promotes glucose oxidation. "
4.	Pyruvate Dehydrogenase Complex Deficiency Disease 07/01/2019 - "A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency." 10/01/2015 - "In this review, we aim to discuss the relationship between occurrence of epilepsy and PDHc deficiency associated with the pyruvate dehydrogenase complex (E1α subunit (PDHA1) and E1β subunit (PDHB)) and PDH phosphatase (PDP) deficiency. "
5.	Neoplasms (Cancer) 08/01/2014 - "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." 01/01/2018 - "Additionally, we found that PDHA1 and the PDC activator pyruvate dehydrogenase phosphatase 1 (PDP1) are frequently amplified and overexpressed at both the gene and protein levels in prostate tumors. "

Related Drugs and Biologics

1.	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
2.	Glucose (Dextrose)
3.	Pyruvate Dehydrogenase Acetyl-Transferring Kinase
4.	Pyruvic Acid (Pyruvate)
5.	Phosphotransferases (Kinase)
6.	Oxidoreductases (Dehydrogenase)
7.	Insulin (Novolin)
8.	Enzymes
9.	Proteins (Proteins, Gene)
10.	Forkhead Transcription Factors (Forkhead Box Proteins)

Related Therapies and Procedures

1.	Endurance Training