HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Also Known As:
Dehydrogenase Complex, Pyruvate; Complex, Pyruvate Dehydrogenase
Networked: 432 relevant articles (5 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gershwin, M Eric: 13 articles (01/2022 - 06/2002)
2. Coppel, Ross L: 9 articles (01/2022 - 05/2003)
3. Stacpoole, Peter W: 9 articles (10/2019 - 06/2006)
4. Leung, Patrick S C: 8 articles (10/2022 - 05/2003)
5. Palmer, Jeremy M: 8 articles (11/2018 - 02/2002)
6. Harris, Robert A: 8 articles (10/2016 - 06/2003)
7. Ansari, Aftab A: 7 articles (01/2022 - 05/2003)
8. Constantin-Teodosiu, Dumitru: 6 articles (01/2021 - 12/2006)
9. Jones, David E J: 6 articles (09/2008 - 02/2002)
10. Greenhaff, Paul L: 5 articles (01/2021 - 12/2006)

Related Diseases

1. Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
2. Mitochondrial Diseases (Mitochondrial Disease)
3. Hypoxia (Hypoxemia)
4. Hemorrhagic Shock
5. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

Related Drugs and Biologics

1. Pyruvic Acid (Pyruvate)
2. Enzymes
3. Oxidoreductases (Dehydrogenase)
4. Fatty Acids (Saturated Fatty Acids)
5. Melatonin
6. Antibodies
7. Proteins (Proteins, Gene)
8. Autoantigens
9. Glucose (Dextrose)
10. Autoantibodies

Related Therapies and Procedures

1. Therapeutics
2. Caloric Restriction
3. Ketogenic Diet
4. Transplantation
5. Intramuscular Injections