Pyruvaldehyde (Methylglyoxal)

An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.

Also Known As:

Networked: 928 relevant articles (29 outcomes, 112 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thornalley, Paul J: 27 articles (02/2022 - 10/2003)
2.	Fleming, Thomas: 24 articles (01/2022 - 11/2009)
3.	Schalkwijk, Casper G: 22 articles (11/2022 - 09/2006)
4.	Rabbani, Naila: 22 articles (02/2022 - 10/2008)
5.	Wu, Lingyun: 20 articles (01/2017 - 03/2002)
6.	Nawroth, Peter P: 14 articles (01/2022 - 06/2012)
7.	Stehouwer, Coen D A: 12 articles (11/2022 - 04/2008)
8.	Ray, Manju: 12 articles (06/2019 - 06/2003)
9.	Xue, Mingzhan: 11 articles (02/2022 - 10/2008)
10.	Brownlee, Michael: 11 articles (01/2017 - 01/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2008 - "Contrary to the effect of existing anticancer drugs, this methylglyoxal-based formulation is devoid of any toxic effect and reasonably effective against a wide variety of cancers. " 10/01/2011 - "Atomic force microscopic study demonstrated gross structural alteration specifically of tumor mitochondria on methylglyoxal treatment. " 09/01/2011 - "Together these studies demonstrate a specific effect of methylglyoxal on mitochondrial complex I of malignant cells and importantly some distinct alteration of this complex in cancer cells." 10/01/2009 - "These studies culminated in a recent investigation to evaluate a methylglyoxal-based formulation in treating a small group of cancer patients, and the results were promising. " 11/01/2008 - "The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. "
2.	Inflammation (Inflammations) 12/19/2022 - "Habitual intake of dietary methylglyoxal is associated with less low-grade inflammation: the Maastricht Study." 05/01/2014 - "Furthermore, this study suggests a cascade linking inflammation, reduced GLO-1, methylglyoxal- and AGE-accumulation, and subsequent apoptosis. " 10/01/2022 - "Early postnatal exposure of rat pups to methylglyoxal induces oxidative stress, inflammation and dysmetabolism at adulthood." 01/01/2022 - "Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells." 07/21/2021 - "Unripe Carica papaya Protects Methylglyoxal-Invoked Endothelial Cell Inflammation and Apoptosis via the Suppression of Oxidative Stress and Akt/MAPK/NF-κB Signals."
3.	Wounds and Injuries (Trauma) 01/01/2023 - "First, we found that the expression of Keap1 was upregulated in the wounds of diabetic mice and in human umbilical vein endothelial cells (HUVECs) pretreated with methylglyoxal (MGO). " 01/20/2022 - "Co-treatment of the cells either with NAC and methylglyoxal or with FER-1 and methylglyoxal attenuated methylglyoxal-induced injuries in the osteoblasts (P < 0.001). " 08/16/2017 - "Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal." 10/01/2015 - "Human umbilical vein endothelial cells (HUVECs) were stimulated by serial concentrations of methylglyoxal (MGO, 0, 25, 50, 100 and 200 µmol/L) for 24 h, and the cell migration was assessed by scratch wound and Transwell assay. " 10/01/2015 - "Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats."
4.	Neuroblastoma 01/01/2016 - "Improved Mitochondrial and Methylglyoxal-Related Metabolisms Support Hyperproliferation Induced by 50 Hz Magnetic Field in Neuroblastoma Cells." 01/01/2017 - "The present study focused on the methylglyoxal (MG) detoxification mechanism in neuroblastoma cells. " 01/01/2020 - "In the present work, we have treated the human neuroblastoma SH-SY5Y cell line with KW at 0.1-10 μM for 12 h prior to a challenge with methylglyoxal (MG), a reactive dicarbonyl that impairs mitochondrial function. " 04/01/2017 - "Human neuroblastoma SH-SY5Y cells were pretreated (4 h) with PB (0-25 µM) and then exposed to methylglyoxal (MG; 500 µM) for further 24 h. " 01/01/2017 - "Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism."
5.	Peritoneal Fibrosis 01/01/2017 - "Peritoneal fibrosis was induced by peritoneal injection of methylglyoxal (MGO) in male C57/B6 mice for 3 weeks. " 01/01/2014 - "Peritoneal fibrosis induced by intraperitoneal methylglyoxal injection: the role of concurrent renal dysfunction." 01/01/2018 - "Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO) into male C57/BL6 mice over 21 days. " 01/01/2017 - "Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis." 01/01/2016 - "Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice."

Related Drugs and Biologics

1.	Metformin (Glucophage)
2.	Streptozocin (Streptozotocin)
3.	Ergothioneine
4.	hispidin
5.	Advanced Glycation End Products
6.	Proteins (Proteins, Gene)
7.	Enzymes
8.	imidazolone
9.	N(6)-carboxymethyllysine (carboxymethyllysine)
10.	pimagedine (aminoguanidine)

Related Therapies and Procedures

1.	Peritoneal Dialysis
2.	Drug Therapy (Chemotherapy)
3.	Catheters
4.	Transplantation
5.	Resuscitation