|1.||Wu, Lingyun: 17 articles (12/2011 - 03/2002)|
|2.||Thornalley, Paul J: 15 articles (06/2014 - 07/2005)|
|3.||Schalkwijk, Casper G: 9 articles (06/2015 - 09/2006)|
|4.||Rabbani, Naila: 9 articles (06/2014 - 10/2008)|
|5.||Ray, Manju: 8 articles (01/2015 - 06/2003)|
|6.||Brownlee, Michael: 8 articles (06/2014 - 01/2006)|
|7.||Münch, Gerald: 7 articles (01/2013 - 01/2005)|
|8.||Vasdev, Sudesh: 7 articles (12/2011 - 01/2004)|
|9.||Stehouwer, Coen D A: 6 articles (06/2015 - 04/2008)|
|10.||Pan, Tzu-Ming: 6 articles (07/2014 - 12/2012)|
04/01/2010 - "Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. "
01/01/2008 - "Contrary to the effect of existing anticancer drugs, this methylglyoxal-based formulation is devoid of any toxic effect and reasonably effective against a wide variety of cancers. "
10/01/2011 - "Atomic force microscopic study demonstrated gross structural alteration specifically of tumor mitochondria on methylglyoxal treatment. "
09/01/2011 - "Together these studies demonstrate a specific effect of methylglyoxal on mitochondrial complex I of malignant cells and importantly some distinct alteration of this complex in cancer cells."
10/01/2009 - "These studies culminated in a recent investigation to evaluate a methylglyoxal-based formulation in treating a small group of cancer patients, and the results were promising. "
04/10/2015 - "The levels of ADTIQ and methylglyoxal were detected by LC-MS/MS. Here we report the chemical synthesis of ADTIQ, demonstrate its biosynthesis in SH-SY5Y neuroblastoma cell line and investigate its role in the pathogenesis of PD. "
10/15/2003 - "To this purpose, we comparatively evaluated the signaling transduction pathway elicited by methylglyoxal in human glioblastoma (ADF) and neuroblastoma (SH-SY 5Y) cells. "
12/05/2015 - "Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells."
06/01/2006 - "To simulate a reduced glyoxalase I activity, we applied an inhibitor of glyoxalase I, p-bromobenzylglutathione cyclopentyl diester (pBrBzGSCp(2)), to SH-SY5Y neuroblastoma cells to induce chronically elevated methylglyoxal concentrations. "
06/15/2015 - "The aim of this study was to investigate the role of sulforaphane, an isothiocyanate found in cruciferous vegetables, in counteracting methylglyoxal-induced damage in SH-SY5Y neuroblastoma cells. "
08/01/2009 - "The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats. "
07/01/2014 - "In this work, we have evaluated the role of the AGE precursor methylglyoxal (MGO) in generating endothelial insulin resistance both in cells and in animal models. "
08/01/2009 - "These results indicate that methylglyoxal-induced insulin resistance and salt sensitivity at least in part by increasing oxidative stress and/or AGEs formation in Sprague-Dawley rats. "
08/01/2009 - "Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats."
11/25/2006 - "Methylglyoxal (MG), a highly reactive molecule, has been implicated in the development of insulin resistance. "
05/01/2014 - "Furthermore, this study suggests a cascade linking inflammation, reduced GLO-1, methylglyoxal- and AGE-accumulation, and subsequent apoptosis. "
03/01/2015 - "Serum levels of methylglyoxal-derived hydroimidazolone-1 in diabetes patients are increased and associated with low-grade inflammation, but not yet arterial stiffness or wall thickness. "
06/26/2013 - "Abnormal cellular accumulation of the dicarbonyl metabolite methylglyoxal (MG) results in cell damage, inflammation, and oxidative stress. "
08/01/2012 - "The article deals with studying of the relationship between biologic reaction of inflammation with glycosylation reaction and content of methylglyoxal in blood serum. "
12/01/2008 - "Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells."
|5.||Diabetic Nephropathies (Diabetic Nephropathy)
01/01/2014 - "The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy."
12/05/2013 - "Advanced glycation endproducts (AGEs) and its precursor methylglyoxal are associated with diabetic nephropathy (DN). "
03/01/2011 - "To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN). "
03/01/2011 - "Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy."
12/01/2014 - "(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice."
|2.||Catechin (Z 7300)
|3.||1- (5- hydroxy- 3- methyl- 1- phenyl- 1H- pyrazol- 4- yl)- 6- methyl- 1,3- dihydrofuro(3,4- c)pyridine- 7- ol
|6.||Proteins (Proteins, Gene)
|10.||Advanced Glycosylation End Products
|4.||Drug Therapy (Chemotherapy)
|5.||Carbohydrate-Restricted Diet (Low Carbohydrate Diet)