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Pyrrolizidine Alkaloids

A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Also Known As:
Alkaloid, Pyrrolizidine; Alkaloid, Senecio; Alkaloids, Pyrrolizidine; Alkaloids, Senecio; Pyrrolizidine Alkaloid; Senecio Alkaloid; Senecio Alkaloids
Networked: 290 relevant articles (7 outcomes, 17 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Fu, Peter P: 19 articles (01/2022 - 01/2003)
2. Lin, Ge: 17 articles (07/2022 - 04/2011)
3. Xia, Qingsu: 15 articles (01/2022 - 01/2003)
4. Ye, Yang: 9 articles (07/2022 - 04/2011)
5. Yang, Li: 9 articles (04/2022 - 08/2011)
6. Chou, Ming W: 8 articles (03/2010 - 01/2003)
7. Zhuge, Yuzheng: 7 articles (06/2022 - 04/2019)
8. Li, Na: 7 articles (12/2017 - 04/2011)
9. Ma, Jiang: 6 articles (07/2022 - 12/2017)
10. Xiong, Aizhen: 6 articles (01/2022 - 08/2014)

Related Diseases

1. Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive)
2. Poisoning
3. Neoplasms (Cancer)
4. Pulmonary Hypertension
5. Liver Diseases (Liver Disease)

Related Drugs and Biologics

1. Monocrotaline
2. dehydroretronecine
3. Antimitotic Agents
4. Heme Oxygenase-1
5. Heme (Haem)
6. Ethoxyquin
7. Disulfiram (Antabuse)
8. Cysteine (L-Cysteine)
9. Butylated Hydroxyanisole (BHA)
10. 3,5-diisopropylsalicylic acid (DIPS)

Related Therapies and Procedures

1. Surgical Portasystemic Shunt (Portosystemic Shunt)
2. Hematopoietic Stem Cell Transplantation
3. Therapeutics
4. Traditional Medicine (Folk Remedies)
5. Subcutaneous Injections