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Pyrrolizidine Alkaloids

A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Also Known As:
Alkaloids, Pyrrolizidine; Alkaloids, Senecio; Senecio Alkaloids
Networked: 81 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fu, Peter P: 6 articles (01/2016 - 04/2005)
2. Lin, Ge: 5 articles (01/2016 - 01/2012)
3. Li, Na: 4 articles (10/2015 - 01/2012)
4. Xia, Qingsu: 4 articles (01/2014 - 05/2008)
5. Gao, Hong: 3 articles (10/2015 - 01/2012)
6. Zhao, Yuewei: 3 articles (01/2014 - 03/2010)
7. Chou, Ming W: 3 articles (03/2010 - 04/2005)
8. Ruan, Jianqing: 2 articles (01/2016 - 10/2015)
9. Zheng, Jiang: 2 articles (10/2015 - 08/2013)
10. Ye, Yang: 2 articles (10/2015 - 01/2015)

Related Diseases

1. Poisoning
2. Liver Diseases (Liver Disease)
3. Hepatocellular Carcinoma (Hepatoma)
4. Neoplasms (Cancer)
5. Necrosis

Related Drugs and Biologics

1. Ethoxyquin
2. Disulfiram (Antabuse)
3. Butylated Hydroxyanisole (BHA)
4. Monocrotaline
5. DNA Adducts
6. retronecine
7. otonecine
8. clivorine
9. riddelliine
10. dehydroretronecine

Related Therapies and Procedures

1. Hematopoietic Stem Cell Transplantation
2. Drug Therapy (Chemotherapy)